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Preparation and Characterization of Demineralized Bone Extracellular Matrix/Chitosan Porous Microcarriers.

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Title: Preparation and Characterization of Demineralized Bone Extracellular Matrix/Chitosan Porous Microcarriers.
Authors: Jiang, Jie1 (AUTHOR), Fang, Jianjun1 (AUTHOR) fang_88088@163.com, Liu, Wenjuan2 (AUTHOR), Guo, Meimei1 (AUTHOR), Lu, Zhongjia1 (AUTHOR), Tang, Heng1 (AUTHOR), Lan, Yi3 (AUTHOR), Zhou, Zhihua1,2,4 (AUTHOR) zhou7381@126.com
Source: Journal of Macromolecular Science: Physics. 2026, Vol. 65 Issue 1, p102-114. 13p.
Subjects: Cytocompatibility, Biocompatibility, Scanning electron microscopes, Extracellular matrix, Chitosan, Biomaterials, Freeze-drying, Emulsions
Abstract: Composite porous microcarriers based on demineralized bone extracellular matrix (DBECM) and chitosan (Cs) were prepared using a combined emulsion and freeze-drying method. The effects of digestion by pepsin on the DBECM properties were investigated. The morphologies and porous structure of the DBECM/Cs porous microcarriers were observed by using a scanning electron microscope (SEM). The cytocompatibility of the DBECM/Cs porous microcarriers were studied by using cell counting kit-8 (CCK-8) and calcein acetoxymethyl ester/propidium iodide (CAM/PI). DBECM was digested into small pieces with a loose porous sponge structure and the digested DBECM showed an amorphous state. The resultant DBECM/Cs porous microcarriers showed a spherical shape and an interconnective porous structure. The CCK-8 and CAM/PI analyses indicated that the DBECM/Cs porous microcarriers were non-cytotoxic and showed good biocompatibility, providing a more favorable growth environment for cells. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Macromolecular Science: Physics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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  Label: Title
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  Data: Preparation and Characterization of Demineralized Bone Extracellular Matrix/Chitosan Porous Microcarriers.
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  Data: <searchLink fieldCode="AR" term="%22Jiang%2C+Jie%22">Jiang, Jie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fang%2C+Jianjun%22">Fang, Jianjun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> fang_88088@163.com</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Wenjuan%22">Liu, Wenjuan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Meimei%22">Guo, Meimei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Zhongjia%22">Lu, Zhongjia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Heng%22">Tang, Heng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lan%2C+Yi%22">Lan, Yi</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Zhihua%22">Zhou, Zhihua</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<i> zhou7381@126.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Macromolecular+Science%3A+Physics%22">Journal of Macromolecular Science: Physics</searchLink>. 2026, Vol. 65 Issue 1, p102-114. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Cytocompatibility%22">Cytocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+electron+microscopes%22">Scanning electron microscopes</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Chitosan%22">Chitosan</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink><br /><searchLink fieldCode="DE" term="%22Freeze-drying%22">Freeze-drying</searchLink><br /><searchLink fieldCode="DE" term="%22Emulsions%22">Emulsions</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Composite porous microcarriers based on demineralized bone extracellular matrix (DBECM) and chitosan (Cs) were prepared using a combined emulsion and freeze-drying method. The effects of digestion by pepsin on the DBECM properties were investigated. The morphologies and porous structure of the DBECM/Cs porous microcarriers were observed by using a scanning electron microscope (SEM). The cytocompatibility of the DBECM/Cs porous microcarriers were studied by using cell counting kit-8 (CCK-8) and calcein acetoxymethyl ester/propidium iodide (CAM/PI). DBECM was digested into small pieces with a loose porous sponge structure and the digested DBECM showed an amorphous state. The resultant DBECM/Cs porous microcarriers showed a spherical shape and an interconnective porous structure. The CCK-8 and CAM/PI analyses indicated that the DBECM/Cs porous microcarriers were non-cytotoxic and showed good biocompatibility, providing a more favorable growth environment for cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Macromolecular Science: Physics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/00222348.2024.2409526
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 102
    Subjects:
      – SubjectFull: Cytocompatibility
        Type: general
      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Scanning electron microscopes
        Type: general
      – SubjectFull: Extracellular matrix
        Type: general
      – SubjectFull: Chitosan
        Type: general
      – SubjectFull: Biomaterials
        Type: general
      – SubjectFull: Freeze-drying
        Type: general
      – SubjectFull: Emulsions
        Type: general
    Titles:
      – TitleFull: Preparation and Characterization of Demineralized Bone Extracellular Matrix/Chitosan Porous Microcarriers.
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            NameFull: Jiang, Jie
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            NameFull: Fang, Jianjun
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            NameFull: Liu, Wenjuan
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            NameFull: Guo, Meimei
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              M: 01
              Text: 2026
              Type: published
              Y: 2026
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