Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction for pH-responsive and bone-targeted osteoporosis therapy.
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| Title: | Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction for pH-responsive and bone-targeted osteoporosis therapy. |
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| Authors: | Luo, Peng1,2 (AUTHOR), Fu, Jiaming1 (AUTHOR), Yang, Xiaowei1,3 (AUTHOR), Mo, Fengbo1 (AUTHOR), Zhong, Yanlong1,3 (AUTHOR), Lai, Qi1,3 (AUTHOR), Huang, Shaorong1,4 (AUTHOR) huangshaorong@ncmc.edu.cn, Zhang, Xiaoyong1,3 (AUTHOR) zhangxiaoyong@ncu.edu.cn, Zhang, Bin1 (AUTHOR) yxwzb11@126.com, Wei, Yen5 (AUTHOR) |
| Source: | Materials & Design. Jan2026, Vol. 261, pN.PAG-N.PAG. 1p. |
| Subjects: | Osteoporosis, Nanomedicine, Drugs, Smart materials, Controlled release drugs, Therapeutics |
| Abstract: | [Display omitted] • Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction. • HPGCA can self-assemble into water dispersible nanoparticles. • HPGCA shows pH-dependent drug release and bone-targeting capability. • HPGCA showed better anti-osteoporosis efficacy than both free Cur and ALN. Osteoporosis is one of the most common chronic metabolic diseases that mainly caused by an imbalance in bone homeostasis. Considered its severe concurrent disorders, osteoporosis has become a global health issue, however, the anti-osteoporosis medications available in clinical practice are confronted with challenges such as high costs, adverse side effects, and limited efficacy. Herein, we reported construction of pH-responsive and bone-targeting nanomedicine (termed HPGCA) via click conjugation of alkyne functionalized hyperbranched polyglycerol (HPG) with curcumin (Cur) and alendronate (ALN) for the first time. We demonstrated that HPGCA exhibit superior water dispersibility, small particle size, and pH-dependent drug release behavior. Results from biological assays indicated that HPGCA displayed desirable bone-targeting capability, strong anti-osteoporosis efficacy, good hemocompatibility, and negligible adverse effects. More importantly, HPGCA showed better anti-osteoporosis efficacy than both free Cur and ALN according results from micro-CT and TRAP staining. The synergistic osteoporosis therapeutic efficacy would be explained by targeting delivering HPGCA to bone tissues and in-situ releasing cargos under acidic environment. Therefore, considered the above aspects, we believe that the innovative nanomedicine is promising for osteoporosis therapy in clinic and will provide new insights for full realization anti-osteoporotic properties of natural compounds. [ABSTRACT FROM AUTHOR] |
| Copyright of Materials & Design is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 190716079 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction for pH-responsive and bone-targeted osteoporosis therapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Luo%2C+Peng%22">Luo, Peng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Jiaming%22">Fu, Jiaming</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Xiaowei%22">Yang, Xiaowei</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mo%2C+Fengbo%22">Mo, Fengbo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Yanlong%22">Zhong, Yanlong</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai%2C+Qi%22">Lai, Qi</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Shaorong%22">Huang, Shaorong</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> huangshaorong@ncmc.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiaoyong%22">Zhang, Xiaoyong</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> zhangxiaoyong@ncu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bin%22">Zhang, Bin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yxwzb11@126.com</i><br /><searchLink fieldCode="AR" term="%22Wei%2C+Yen%22">Wei, Yen</searchLink><relatesTo>5</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Materials+%26+Design%22">Materials & Design</searchLink>. Jan2026, Vol. 261, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Osteoporosis%22">Osteoporosis</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Smart+materials%22">Smart materials</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: [Display omitted] • Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction. • HPGCA can self-assemble into water dispersible nanoparticles. • HPGCA shows pH-dependent drug release and bone-targeting capability. • HPGCA showed better anti-osteoporosis efficacy than both free Cur and ALN. Osteoporosis is one of the most common chronic metabolic diseases that mainly caused by an imbalance in bone homeostasis. Considered its severe concurrent disorders, osteoporosis has become a global health issue, however, the anti-osteoporosis medications available in clinical practice are confronted with challenges such as high costs, adverse side effects, and limited efficacy. Herein, we reported construction of pH-responsive and bone-targeting nanomedicine (termed HPGCA) via click conjugation of alkyne functionalized hyperbranched polyglycerol (HPG) with curcumin (Cur) and alendronate (ALN) for the first time. We demonstrated that HPGCA exhibit superior water dispersibility, small particle size, and pH-dependent drug release behavior. Results from biological assays indicated that HPGCA displayed desirable bone-targeting capability, strong anti-osteoporosis efficacy, good hemocompatibility, and negligible adverse effects. More importantly, HPGCA showed better anti-osteoporosis efficacy than both free Cur and ALN according results from micro-CT and TRAP staining. The synergistic osteoporosis therapeutic efficacy would be explained by targeting delivering HPGCA to bone tissues and in-situ releasing cargos under acidic environment. Therefore, considered the above aspects, we believe that the innovative nanomedicine is promising for osteoporosis therapy in clinic and will provide new insights for full realization anti-osteoporotic properties of natural compounds. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Materials & Design is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.matdes.2025.115291 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Osteoporosis Type: general – SubjectFull: Nanomedicine Type: general – SubjectFull: Drugs Type: general – SubjectFull: Smart materials Type: general – SubjectFull: Controlled release drugs Type: general – SubjectFull: Therapeutics Type: general Titles: – TitleFull: Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction for pH-responsive and bone-targeted osteoporosis therapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Luo, Peng – PersonEntity: Name: NameFull: Fu, Jiaming – PersonEntity: Name: NameFull: Yang, Xiaowei – PersonEntity: Name: NameFull: Mo, Fengbo – PersonEntity: Name: NameFull: Zhong, Yanlong – PersonEntity: Name: NameFull: Lai, Qi – PersonEntity: Name: NameFull: Huang, Shaorong – PersonEntity: Name: NameFull: Zhang, Xiaoyong – PersonEntity: Name: NameFull: Zhang, Bin – PersonEntity: Name: NameFull: Wei, Yen IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 02641275 Numbering: – Type: volume Value: 261 Titles: – TitleFull: Materials & Design Type: main |
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