View in EDS HTML Full Text PDF Full Text

Effect of coamorphization on meloxicam/saccharine: Intermolecular interaction investigations using chemometrics.

Saved in:
Bibliographic Details
Title: Effect of coamorphization on meloxicam/saccharine: Intermolecular interaction investigations using chemometrics.
Authors: Otsuka, Yuta1 (AUTHOR) y.otsuka36156803@gmail.com
Source: Bio-Medical Materials & Engineering. Jan2026, Vol. 37 Issue 1, p3-12. 10p.
Subjects: Saccharin, Intermolecular interactions, Anti-inflammatory agents, Solubility, Chemometrics, Amorphization, Multivariate analysis, Bioavailability
Abstract: Background: Aqueous solubility of pharmaceuticals is a factor as it is directly associated with bioavailability; accordingly, strategies to enhance solubility have been well investigated. Objectives: The purpose of this study was to determine the effects of coamorphization on meloxicam (MX) and saccharine (SA) mixtures. Methods: An equimolar mixture of MX and SA was ground for 4 h at 300 rpm. The obtained samples were evaluated using Fourier-transform mid-infrared spectroscopy, Fourier transform near-infrared spectroscopy, powder X-ray diffraction (PXRD), and thermal analysis. No molecular interactions were observed in the physical mixture sample. The ground samples showed broad peaks in the PXRD patterns and an exothermic peak at an early temperature. Results: The results suggested that the grinding process transformed MX and SA into a coamorphous phase. The attenuated total reflection - IR spectra exhibited new peaks at 1719 cm−1 and 1398 cm−1, and the NH peak disappeared with grinding time. Measurement data of MX and SA ground sample suggested they constructed coamorphous phase. Conclusion: It was indicated by multivariate analysis that the formation of the MX/SA coamorphous system occurred in a two-step process. [ABSTRACT FROM AUTHOR]
Copyright of Bio-Medical Materials & Engineering is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: egs
DbLabel: Engineering Source
An: 190954272
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of coamorphization on meloxicam/saccharine: Intermolecular interaction investigations using chemometrics.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Otsuka%2C+Yuta%22">Otsuka, Yuta</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> y.otsuka36156803@gmail.com</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Bio-Medical+Materials+%26+Engineering%22">Bio-Medical Materials & Engineering</searchLink>. Jan2026, Vol. 37 Issue 1, p3-12. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Saccharin%22">Saccharin</searchLink><br /><searchLink fieldCode="DE" term="%22Intermolecular+interactions%22">Intermolecular interactions</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Solubility%22">Solubility</searchLink><br /><searchLink fieldCode="DE" term="%22Chemometrics%22">Chemometrics</searchLink><br /><searchLink fieldCode="DE" term="%22Amorphization%22">Amorphization</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Bioavailability%22">Bioavailability</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Aqueous solubility of pharmaceuticals is a factor as it is directly associated with bioavailability; accordingly, strategies to enhance solubility have been well investigated. Objectives: The purpose of this study was to determine the effects of coamorphization on meloxicam (MX) and saccharine (SA) mixtures. Methods: An equimolar mixture of MX and SA was ground for 4 h at 300 rpm. The obtained samples were evaluated using Fourier-transform mid-infrared spectroscopy, Fourier transform near-infrared spectroscopy, powder X-ray diffraction (PXRD), and thermal analysis. No molecular interactions were observed in the physical mixture sample. The ground samples showed broad peaks in the PXRD patterns and an exothermic peak at an early temperature. Results: The results suggested that the grinding process transformed MX and SA into a coamorphous phase. The attenuated total reflection - IR spectra exhibited new peaks at 1719 cm−1 and 1398 cm−1, and the NH peak disappeared with grinding time. Measurement data of MX and SA ground sample suggested they constructed coamorphous phase. Conclusion: It was indicated by multivariate analysis that the formation of the MX/SA coamorphous system occurred in a two-step process. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Bio-Medical Materials & Engineering is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=190954272
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1177/09592989251341175
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 3
    Subjects:
      – SubjectFull: Saccharin
        Type: general
      – SubjectFull: Intermolecular interactions
        Type: general
      – SubjectFull: Anti-inflammatory agents
        Type: general
      – SubjectFull: Solubility
        Type: general
      – SubjectFull: Chemometrics
        Type: general
      – SubjectFull: Amorphization
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Bioavailability
        Type: general
    Titles:
      – TitleFull: Effect of coamorphization on meloxicam/saccharine: Intermolecular interaction investigations using chemometrics.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Otsuka, Yuta
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 09592989
          Numbering:
            – Type: volume
              Value: 37
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Bio-Medical Materials & Engineering
              Type: main
ResultId 1