From Corrosion Control to Cell Adhesion: Parascholzite as a Functional Interface for Biodegradable Zinc Alloys.
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| Title: | From Corrosion Control to Cell Adhesion: Parascholzite as a Functional Interface for Biodegradable Zinc Alloys. |
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| Authors: | Fojt, Jaroslav1 (AUTHOR) fojtj@vscht.cz, Veselý, Jakub1,2 (AUTHOR), Šťovíček, Jan1 (AUTHOR), Pokorný, Jan1,2 (AUTHOR), Jablonská, Eva2 (AUTHOR), Míchal, Zdeněk2 (AUTHOR), Hybášek, Vojtěch1 (AUTHOR) |
| Source: | Materials (1996-1944). Jan2026, Vol. 19 Issue 2, p416. 14p. |
| Subjects: | Cytocompatibility, Cell adhesion, Corrosion control industry, Surface chemistry, Phosphate coating, Artificial implants, Zinc alloys, Surface coatings |
| Abstract: | Zinc-based alloys are promising candidates for biodegradable implant applications; however, their rapid initial corrosion and limited cytocompatibility remain major challenges. In this study, a Zn-Ca-P layer in a form of parascholzite (CaZn2(PO4)2·2H2O) was prepared on a Zn-0.8Mg-0.2Sr alloy via anodic oxidation followed by short-time biomimetic calcium–phosphate deposition. The formation mechanism, corrosion behaviour, and preliminary biological response of the modified surface were systematically investigated. The Zn-Ca-P layer formed a compact and crystalline phosphate layer that significantly altered the corrosion response of the zinc substrate in Leibovitz L-15 medium containing foetal bovine serum. Electrochemical measurements revealed a pronounced improvement in corrosion resistance and a transition from rapid active dissolution to a controlled, ion-exchange-driven degradation mechanism. The moderate solubility of parascholzite enabled the gradual release of Zn2+ and Ca2+ ions while maintaining surface stability during immersion. Preliminary cell adhesion experiments demonstrated a clear enhancement of cytocompatibility for the Zn-Ca-P-layer-coated samples, where cells readily adhered and spread, in contrast to the bare alloy surface, which showed lower cell attachment. The improved biological response is attributed to the phosphate-rich surface chemistry, favourable surface morphology, and moderated corrosion behaviour. Overall, the parascholzite-like layer provides an effective strategy with which to regulate both corrosion and early cell–material interactions of zinc-based biodegradable alloys, highlighting its potential for temporary biomedical implant applications. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Zinc-based alloys are promising candidates for biodegradable implant applications; however, their rapid initial corrosion and limited cytocompatibility remain major challenges. In this study, a Zn-Ca-P layer in a form of parascholzite (CaZn2(PO4)2·2H2O) was prepared on a Zn-0.8Mg-0.2Sr alloy via anodic oxidation followed by short-time biomimetic calcium–phosphate deposition. The formation mechanism, corrosion behaviour, and preliminary biological response of the modified surface were systematically investigated. The Zn-Ca-P layer formed a compact and crystalline phosphate layer that significantly altered the corrosion response of the zinc substrate in Leibovitz L-15 medium containing foetal bovine serum. Electrochemical measurements revealed a pronounced improvement in corrosion resistance and a transition from rapid active dissolution to a controlled, ion-exchange-driven degradation mechanism. The moderate solubility of parascholzite enabled the gradual release of Zn2+ and Ca2+ ions while maintaining surface stability during immersion. Preliminary cell adhesion experiments demonstrated a clear enhancement of cytocompatibility for the Zn-Ca-P-layer-coated samples, where cells readily adhered and spread, in contrast to the bare alloy surface, which showed lower cell attachment. The improved biological response is attributed to the phosphate-rich surface chemistry, favourable surface morphology, and moderated corrosion behaviour. Overall, the parascholzite-like layer provides an effective strategy with which to regulate both corrosion and early cell–material interactions of zinc-based biodegradable alloys, highlighting its potential for temporary biomedical implant applications. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 19961944 |
| DOI: | 10.3390/ma19020416 |
