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Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei.

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Title: Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei.
Authors: Chen, Lo-Yun1 (AUTHOR), Peng, Bo-Rong1,2,3,4 (AUTHOR), Huynh, Thanh Hao3,4 (AUTHOR), Chen, You-Ying5,6 (AUTHOR), Chen, Yu-Cheng3,4 (AUTHOR), Pham, Ngoc-Thac1 (AUTHOR), Le, Huong-Giang7 (AUTHOR), Pham, Quoc-Vu2 (AUTHOR), Luu, Phuong Vu2 (AUTHOR), Lai, Ying-Mi8 (AUTHOR), El-Shazly, Mohamed9 (AUTHOR), Hwang, Tsong-Long3,10,11,12 (AUTHOR), Lai, Kuei-Hung1,2,13,14 (AUTHOR) kueihunglai@tmu.edu.tw
Source: Phytochemistry. Apr2026, Vol. 244, pN.PAG-N.PAG. 1p.
Subjects: Anti-inflammatory agents, Aquaculture, Metabolomics, Therapeutics, Alcyonacea
Abstract: In this study, by using untargeted LC-MS/MS-based multi-informative molecular networking, 12 briarane diterpenoids were isolated from a closed-system cultured soft coral Briareum stechei. Among them, six unreported compounds were identified and named briastechols A–F (1 – 6). Notably, briastechols A (1) and B (2) possess a rare 11,14-ether bridge, while briastechols C (3) and D (4) feature a tetrahydrofuran moiety with an ether linkage between C-5 and C-8. Additionally, the absolute configurations of briastechol F (6) and briarenol H (10) were determined for the first time via X-ray crystallographic analysis. Evaluation of bioactivity indicated that the crude extract exerted pronounced anti-inflammatory effects, as reflected in the inhibition of superoxide anion formation and elastase secretion in human neutrophils triggered by N -formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB). Among the isolated compounds, briastechol E (5) showed significant anti-inflammatory potential, with IC 50 values of 7.89 ± 0.38 μM and 4.53 ± 0.68 μM against superoxide anion generation and elastase release, respectively. These findings underscore the structural novelty and chemical diversity of metabolites from cultured B. stechei using a closed system, highlighting its potential as a sustainable source of anti-inflammatory agents and further supporting the viability of closed aquaculture systems for marine natural product research. Six unreported briarane diterpenoids were identified from Briareum stechei via molecular networking, with compound 5 showing potent anti-inflammatory activity through inhibition of superoxide anion generation and elastase release. [Display omitted] • First metabolomic and chemical study of Briareum stechei from aquaculture. • Six previously unreported briarane diterpenes discovered, two with rare carbon skeletons. • Structures elucidated by spectroscopy, DP4+ computation, and X-ray analysis. • Briastechol E (5) showed notable anti-inflammatory activity. [ABSTRACT FROM AUTHOR]
Copyright of Phytochemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 191270118
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Briarane-type diterpenes from a closed-system cultured soft coral Briareum stechei.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Lo-Yun%22">Chen, Lo-Yun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peng%2C+Bo-Rong%22">Peng, Bo-Rong</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huynh%2C+Thanh+Hao%22">Huynh, Thanh Hao</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+You-Ying%22">Chen, You-Ying</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Yu-Cheng%22">Chen, Yu-Cheng</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pham%2C+Ngoc-Thac%22">Pham, Ngoc-Thac</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Le%2C+Huong-Giang%22">Le, Huong-Giang</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pham%2C+Quoc-Vu%22">Pham, Quoc-Vu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luu%2C+Phuong+Vu%22">Luu, Phuong Vu</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai%2C+Ying-Mi%22">Lai, Ying-Mi</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22El-Shazly%2C+Mohamed%22">El-Shazly, Mohamed</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hwang%2C+Tsong-Long%22">Hwang, Tsong-Long</searchLink><relatesTo>3,10,11,12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai%2C+Kuei-Hung%22">Lai, Kuei-Hung</searchLink><relatesTo>1,2,13,14</relatesTo> (AUTHOR)<i> kueihunglai@tmu.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Phytochemistry%22">Phytochemistry</searchLink>. Apr2026, Vol. 244, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Aquaculture%22">Aquaculture</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolomics%22">Metabolomics</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Alcyonacea%22">Alcyonacea</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In this study, by using untargeted LC-MS/MS-based multi-informative molecular networking, 12 briarane diterpenoids were isolated from a closed-system cultured soft coral Briareum stechei. Among them, six unreported compounds were identified and named briastechols A–F (1 – 6). Notably, briastechols A (1) and B (2) possess a rare 11,14-ether bridge, while briastechols C (3) and D (4) feature a tetrahydrofuran moiety with an ether linkage between C-5 and C-8. Additionally, the absolute configurations of briastechol F (6) and briarenol H (10) were determined for the first time via X-ray crystallographic analysis. Evaluation of bioactivity indicated that the crude extract exerted pronounced anti-inflammatory effects, as reflected in the inhibition of superoxide anion formation and elastase secretion in human neutrophils triggered by N -formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB). Among the isolated compounds, briastechol E (5) showed significant anti-inflammatory potential, with IC 50 values of 7.89 ± 0.38 μM and 4.53 ± 0.68 μM against superoxide anion generation and elastase release, respectively. These findings underscore the structural novelty and chemical diversity of metabolites from cultured B. stechei using a closed system, highlighting its potential as a sustainable source of anti-inflammatory agents and further supporting the viability of closed aquaculture systems for marine natural product research. Six unreported briarane diterpenoids were identified from Briareum stechei via molecular networking, with compound 5 showing potent anti-inflammatory activity through inhibition of superoxide anion generation and elastase release. [Display omitted] • First metabolomic and chemical study of Briareum stechei from aquaculture. • Six previously unreported briarane diterpenes discovered, two with rare carbon skeletons. • Structures elucidated by spectroscopy, DP4+ computation, and X-ray analysis. • Briastechol E (5) showed notable anti-inflammatory activity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Phytochemistry is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.phytochem.2025.114760
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      – Code: eng
        Text: English
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      – SubjectFull: Anti-inflammatory agents
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      – SubjectFull: Aquaculture
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      – SubjectFull: Metabolomics
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      – SubjectFull: Therapeutics
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      – SubjectFull: Alcyonacea
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              Text: Apr2026
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