Study on the antioxidant and anti-inflammatory properties of different morphologies of ceria nanoenzymes with multi enzyme mimetic activity.
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| Title: | Study on the antioxidant and anti-inflammatory properties of different morphologies of ceria nanoenzymes with multi enzyme mimetic activity. |
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| Authors: | Song, Ziyu1 (AUTHOR), Lu, Yuan1 (AUTHOR), Xiang, Meihua1 (AUTHOR), Wen, Ke1 (AUTHOR) wen_k1995@163.com, Liu, Qian1 (AUTHOR) 20211008@jxutcm.edu.cn |
| Source: | Journal of Materials Science: Materials in Medicine. 2/4/2026, Vol. 37 Issue 1, p1-15. 15p. |
| Subjects: | Cerium oxides, Morphology, Anti-inflammatory agents, NF-kappa B, Free radical scavengers, Antioxidants, Nanomedicine, Synthetic enzymes |
| Abstract: | Cerium dioxide (CeO₂) nanozymes are capable of mimicking the activities of superoxide dismutase (SOD) and catalase (CAT), thereby facilitating the scavenging of reactive oxygen species (ROS). This study aims to synthesize CeO₂ nanozymes with different morphologies by controlling reaction conditions and to elucidate the relationship between morphology and antioxidant and anti-inflammatory activities of the same material. The successful preparation of CeO₂ nanozymes with different morphologies was confirmed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Our findings revealed that CeO₂ nanotubes exhibited the strongest total antioxidant capacity. More importantly, all CeO₂ nanozymes with different morphologies demonstrated excellent ROS scavenging abilities and effectively inhibited the activation of the NF-κB signaling pathway, reduced phosphorylated p65 (P-p65) protein levels, and consequently decreased the release of pro-inflammatory cytokines such as IL-6. This study not only elucidates the structure-activity-anti-inflammatory efficacy relationship of CeO₂ nanozymes but also provides a significant theoretical basis for the development of novel anti-inflammatory nanomedicines. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Cerium dioxide (CeO₂) nanozymes are capable of mimicking the activities of superoxide dismutase (SOD) and catalase (CAT), thereby facilitating the scavenging of reactive oxygen species (ROS). This study aims to synthesize CeO₂ nanozymes with different morphologies by controlling reaction conditions and to elucidate the relationship between morphology and antioxidant and anti-inflammatory activities of the same material. The successful preparation of CeO₂ nanozymes with different morphologies was confirmed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Our findings revealed that CeO₂ nanotubes exhibited the strongest total antioxidant capacity. More importantly, all CeO₂ nanozymes with different morphologies demonstrated excellent ROS scavenging abilities and effectively inhibited the activation of the NF-κB signaling pathway, reduced phosphorylated p65 (P-p65) protein levels, and consequently decreased the release of pro-inflammatory cytokines such as IL-6. This study not only elucidates the structure-activity-anti-inflammatory efficacy relationship of CeO₂ nanozymes but also provides a significant theoretical basis for the development of novel anti-inflammatory nanomedicines. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09574530 |
| DOI: | 10.1007/s10856-025-06989-x |
