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Study on the antioxidant and anti-inflammatory properties of different morphologies of ceria nanoenzymes with multi enzyme mimetic activity.

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Title: Study on the antioxidant and anti-inflammatory properties of different morphologies of ceria nanoenzymes with multi enzyme mimetic activity.
Authors: Song, Ziyu1 (AUTHOR), Lu, Yuan1 (AUTHOR), Xiang, Meihua1 (AUTHOR), Wen, Ke1 (AUTHOR) wen_k1995@163.com, Liu, Qian1 (AUTHOR) 20211008@jxutcm.edu.cn
Source: Journal of Materials Science: Materials in Medicine. 2/4/2026, Vol. 37 Issue 1, p1-15. 15p.
Subjects: Cerium oxides, Morphology, Anti-inflammatory agents, NF-kappa B, Free radical scavengers, Antioxidants, Nanomedicine, Synthetic enzymes
Abstract: Cerium dioxide (CeO₂) nanozymes are capable of mimicking the activities of superoxide dismutase (SOD) and catalase (CAT), thereby facilitating the scavenging of reactive oxygen species (ROS). This study aims to synthesize CeO₂ nanozymes with different morphologies by controlling reaction conditions and to elucidate the relationship between morphology and antioxidant and anti-inflammatory activities of the same material. The successful preparation of CeO₂ nanozymes with different morphologies was confirmed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Our findings revealed that CeO₂ nanotubes exhibited the strongest total antioxidant capacity. More importantly, all CeO₂ nanozymes with different morphologies demonstrated excellent ROS scavenging abilities and effectively inhibited the activation of the NF-κB signaling pathway, reduced phosphorylated p65 (P-p65) protein levels, and consequently decreased the release of pro-inflammatory cytokines such as IL-6. This study not only elucidates the structure-activity-anti-inflammatory efficacy relationship of CeO₂ nanozymes but also provides a significant theoretical basis for the development of novel anti-inflammatory nanomedicines. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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An: 191452919
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  Label: Title
  Group: Ti
  Data: Study on the antioxidant and anti-inflammatory properties of different morphologies of ceria nanoenzymes with multi enzyme mimetic activity.
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  Data: <searchLink fieldCode="AR" term="%22Song%2C+Ziyu%22">Song, Ziyu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lu%2C+Yuan%22">Lu, Yuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xiang%2C+Meihua%22">Xiang, Meihua</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wen%2C+Ke%22">Wen, Ke</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wen_k1995@163.com</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Qian%22">Liu, Qian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> 20211008@jxutcm.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Materials+Science%3A+Materials+in+Medicine%22">Journal of Materials Science: Materials in Medicine</searchLink>. 2/4/2026, Vol. 37 Issue 1, p1-15. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Cerium+oxides%22">Cerium oxides</searchLink><br /><searchLink fieldCode="DE" term="%22Morphology%22">Morphology</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22NF-kappa+B%22">NF-kappa B</searchLink><br /><searchLink fieldCode="DE" term="%22Free+radical+scavengers%22">Free radical scavengers</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Synthetic+enzymes%22">Synthetic enzymes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cerium dioxide (CeO₂) nanozymes are capable of mimicking the activities of superoxide dismutase (SOD) and catalase (CAT), thereby facilitating the scavenging of reactive oxygen species (ROS). This study aims to synthesize CeO₂ nanozymes with different morphologies by controlling reaction conditions and to elucidate the relationship between morphology and antioxidant and anti-inflammatory activities of the same material. The successful preparation of CeO₂ nanozymes with different morphologies was confirmed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Our findings revealed that CeO₂ nanotubes exhibited the strongest total antioxidant capacity. More importantly, all CeO₂ nanozymes with different morphologies demonstrated excellent ROS scavenging abilities and effectively inhibited the activation of the NF-κB signaling pathway, reduced phosphorylated p65 (P-p65) protein levels, and consequently decreased the release of pro-inflammatory cytokines such as IL-6. This study not only elucidates the structure-activity-anti-inflammatory efficacy relationship of CeO₂ nanozymes but also provides a significant theoretical basis for the development of novel anti-inflammatory nanomedicines. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1007/s10856-025-06989-x
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      – Code: eng
        Text: English
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        PageCount: 15
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      – SubjectFull: Cerium oxides
        Type: general
      – SubjectFull: Morphology
        Type: general
      – SubjectFull: Anti-inflammatory agents
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      – SubjectFull: NF-kappa B
        Type: general
      – SubjectFull: Free radical scavengers
        Type: general
      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Nanomedicine
        Type: general
      – SubjectFull: Synthetic enzymes
        Type: general
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      – TitleFull: Study on the antioxidant and anti-inflammatory properties of different morphologies of ceria nanoenzymes with multi enzyme mimetic activity.
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          Name:
            NameFull: Song, Ziyu
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            NameFull: Lu, Yuan
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            NameFull: Xiang, Meihua
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            NameFull: Wen, Ke
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            NameFull: Liu, Qian
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            – D: 04
              M: 02
              Text: 2/4/2026
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              Y: 2026
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              Value: 37
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