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Synthesis of shape‐controlled silica nanoparticles via dual soft templates: A comparative study between aqueous and microemulsion synthesis for the impregnation of procaine anaesthesia drug.

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Title: Synthesis of shape‐controlled silica nanoparticles via dual soft templates: A comparative study between aqueous and microemulsion synthesis for the impregnation of procaine anaesthesia drug.
Authors: Daikh, Zine eddine1,2 (AUTHOR), Zeitoun, Edrees Abu3 (AUTHOR), Fergoug, Teffaha2 (AUTHOR), Bouhadda, Youcef2 (AUTHOR), Derkaoui, Khaled4 (AUTHOR), Bekki, Khaled1,2 (AUTHOR), Kadiri, Aicha2 (AUTHOR), Chaker, Yassine5 (AUTHOR), El Nokab, Mustapha El Hariri6 (AUTHOR), Vojvodin, Cameron S.6 (AUTHOR), Wang, Tuo6 (AUTHOR), Van Steenberge, Paul H. M.7 (AUTHOR), Sebakhy, Khaled O.7 (AUTHOR) khaled.sebakhy@ugent.be
Source: Canadian Journal of Chemical Engineering. Mar2026, Vol. 104 Issue 3, p1262-1282. 21p.
Subjects: Microemulsions, Surface active agents, Silica nanoparticles, Colloidal stability, Drug delivery systems, Pharmaceutical encapsulation, Sol-gel processes, Nanocarriers
Abstract: Silica nanoparticles (SiNPs) are promising drug delivery nanocarriers due to their tunable size, porous structure, and surface properties. This study compares two synthesis methods: (i) a low‐temperature aqueous sol–gel process yielding SiNPs of 500–700 nm, and (ii) a water‐in‐oil (W/O) microemulsion using either CTAB or TX‐100 surfactants. Surfactant selection significantly affected nanoparticle size, stability, and dispersity. Characterization by dynamic light scattering (DLS), scanning electron microscopy (SEM), X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), solid‐state nuclear magnetic resonance spectroscopy (ssNMR), X‐ray photoelectron spectroscopy (XPS), and photoluminescence analysis (PL) confirmed successful synthesis. The TX‐100‐mediated microemulsion method proved particularly effective in achieving highly stable, reproducible, and monodisperse SiNPs, with a size limit of approximately 100 nm, making them ideal candidates for drug encapsulation. Procaine (PRC) incorporation demonstrated the role of reverse micelle dynamics and surfactant‐stabilized interfaces in enhancing encapsulation efficiency. This work highlights the critical role of surfactant and medium selection in SiNPs synthesis, demonstrating their impact on nanoparticle stability, dispersity, and drug loading efficiency. The TX‐100‐mediated microemulsion technique emerges as a superior approach for producing stable, monodisperse SiNPs, advancing the design of nanocarriers for PRC drug delivery applications. [ABSTRACT FROM AUTHOR]
Copyright of Canadian Journal of Chemical Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 191457646
AccessLevel: 6
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  Data: Synthesis of shape‐controlled silica nanoparticles via dual soft templates: A comparative study between aqueous and microemulsion synthesis for the impregnation of procaine anaesthesia drug.
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  Data: <searchLink fieldCode="AR" term="%22Daikh%2C+Zine+eddine%22">Daikh, Zine eddine</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zeitoun%2C+Edrees+Abu%22">Zeitoun, Edrees Abu</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fergoug%2C+Teffaha%22">Fergoug, Teffaha</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bouhadda%2C+Youcef%22">Bouhadda, Youcef</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Derkaoui%2C+Khaled%22">Derkaoui, Khaled</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bekki%2C+Khaled%22">Bekki, Khaled</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kadiri%2C+Aicha%22">Kadiri, Aicha</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chaker%2C+Yassine%22">Chaker, Yassine</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22El+Nokab%2C+Mustapha+El+Hariri%22">El Nokab, Mustapha El Hariri</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vojvodin%2C+Cameron+S%2E%22">Vojvodin, Cameron S.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Tuo%22">Wang, Tuo</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Steenberge%2C+Paul+H%2E+M%2E%22">Van Steenberge, Paul H. M.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sebakhy%2C+Khaled+O%2E%22">Sebakhy, Khaled O.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> khaled.sebakhy@ugent.be</i>
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  Data: <searchLink fieldCode="JN" term="%22Canadian+Journal+of+Chemical+Engineering%22">Canadian Journal of Chemical Engineering</searchLink>. Mar2026, Vol. 104 Issue 3, p1262-1282. 21p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Silica nanoparticles (SiNPs) are promising drug delivery nanocarriers due to their tunable size, porous structure, and surface properties. This study compares two synthesis methods: (i) a low‐temperature aqueous sol–gel process yielding SiNPs of 500–700 nm, and (ii) a water‐in‐oil (W/O) microemulsion using either CTAB or TX‐100 surfactants. Surfactant selection significantly affected nanoparticle size, stability, and dispersity. Characterization by dynamic light scattering (DLS), scanning electron microscopy (SEM), X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), solid‐state nuclear magnetic resonance spectroscopy (ssNMR), X‐ray photoelectron spectroscopy (XPS), and photoluminescence analysis (PL) confirmed successful synthesis. The TX‐100‐mediated microemulsion method proved particularly effective in achieving highly stable, reproducible, and monodisperse SiNPs, with a size limit of approximately 100 nm, making them ideal candidates for drug encapsulation. Procaine (PRC) incorporation demonstrated the role of reverse micelle dynamics and surfactant‐stabilized interfaces in enhancing encapsulation efficiency. This work highlights the critical role of surfactant and medium selection in SiNPs synthesis, demonstrating their impact on nanoparticle stability, dispersity, and drug loading efficiency. The TX‐100‐mediated microemulsion technique emerges as a superior approach for producing stable, monodisperse SiNPs, advancing the design of nanocarriers for PRC drug delivery applications. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Canadian Journal of Chemical Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/cjce.70087
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 21
        StartPage: 1262
    Subjects:
      – SubjectFull: Microemulsions
        Type: general
      – SubjectFull: Surface active agents
        Type: general
      – SubjectFull: Silica nanoparticles
        Type: general
      – SubjectFull: Colloidal stability
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Pharmaceutical encapsulation
        Type: general
      – SubjectFull: Sol-gel processes
        Type: general
      – SubjectFull: Nanocarriers
        Type: general
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      – TitleFull: Synthesis of shape‐controlled silica nanoparticles via dual soft templates: A comparative study between aqueous and microemulsion synthesis for the impregnation of procaine anaesthesia drug.
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            NameFull: Daikh, Zine eddine
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            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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