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Preparation, characterization and in vitro degradation performance of poly (butylene fumarate)-based materials.

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Title: Preparation, characterization and in vitro degradation performance of poly (butylene fumarate)-based materials.
Authors: Wang, Liang1,2 (AUTHOR) wanglcody@163.com, Han, Jiaxin1,2 (AUTHOR), Cao, Yongping1,2 (AUTHOR), Ren, Siqian1,2 (AUTHOR), Ma, Yidan1,2 (AUTHOR)
Source: Journal of Materials Science. Mar2026, Vol. 61 Issue 10, p7108-7121. 14p.
Subjects: Medical polymers, Material biodegradation, Biocompatibility, Gelation, Thermal properties, Methacrylates, Biodegradable plastics
Abstract: Polyalkylene fumarate have been widely regarded as one of the most promising injectable, in-situ crosslinkable, and biodegradable medical polymers. In this study, materials based on a poly (butylene fumarate) (PBF) matrix were synthesized using hydroxyethyl methacrylate (HEMA) as a crosslinking monomer. The crosslinked cured materials with different mass ratios were systematically compared in terms of their composition, gel content, hydrophilicity, thermal properties, adhesive strength, and in vitro degradation behavior. The gel content test results showed that the gel content of the samples exceeded 82%. The crosslinked materials demonstrated good thermal stability, with initial decomposition temperatures ranging from 300.40 to 321.90 °C. Additionally, the hydrophilicity and in vitro degradation behavior of the crosslinked cured materials were systematically evaluated. The contact angles of the materials ranged from 70.73 ± 2.61 to 87.36 ± 7.87°. Furthermore, the bonding strength of the synthesized materials was found to range from 1.53 ± 0.41 to 37.58 ± 0.97 MPa. After 12 weeks of immersion in PBS, the weight loss and degradation rate of the crosslinked materials showed some fluctuations, with a maximum mass loss of approximately 7.28%. PBF/HEMA scaffolds supported enhanced MC3T3-E1 cell proliferation while exhibiting low cytotoxicity, indicating favorable biocompatibility. These results indicate that the synthesized PBF/HEMA materials exhibit good biocompatibility and are suitable for biomedical applications. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Materials Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 191575264
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: Preparation, characterization and in vitro degradation performance of poly (butylene fumarate)-based materials.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Liang%22">Wang, Liang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> wanglcody@163.com</i><br /><searchLink fieldCode="AR" term="%22Han%2C+Jiaxin%22">Han, Jiaxin</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cao%2C+Yongping%22">Cao, Yongping</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ren%2C+Siqian%22">Ren, Siqian</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Yidan%22">Ma, Yidan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Materials+Science%22">Journal of Materials Science</searchLink>. Mar2026, Vol. 61 Issue 10, p7108-7121. 14p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Medical+polymers%22">Medical polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Material+biodegradation%22">Material biodegradation</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Gelation%22">Gelation</searchLink><br /><searchLink fieldCode="DE" term="%22Thermal+properties%22">Thermal properties</searchLink><br /><searchLink fieldCode="DE" term="%22Methacrylates%22">Methacrylates</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradable+plastics%22">Biodegradable plastics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Polyalkylene fumarate have been widely regarded as one of the most promising injectable, in-situ crosslinkable, and biodegradable medical polymers. In this study, materials based on a poly (butylene fumarate) (PBF) matrix were synthesized using hydroxyethyl methacrylate (HEMA) as a crosslinking monomer. The crosslinked cured materials with different mass ratios were systematically compared in terms of their composition, gel content, hydrophilicity, thermal properties, adhesive strength, and in vitro degradation behavior. The gel content test results showed that the gel content of the samples exceeded 82%. The crosslinked materials demonstrated good thermal stability, with initial decomposition temperatures ranging from 300.40 to 321.90 °C. Additionally, the hydrophilicity and in vitro degradation behavior of the crosslinked cured materials were systematically evaluated. The contact angles of the materials ranged from 70.73 ± 2.61 to 87.36 ± 7.87°. Furthermore, the bonding strength of the synthesized materials was found to range from 1.53 ± 0.41 to 37.58 ± 0.97 MPa. After 12 weeks of immersion in PBS, the weight loss and degradation rate of the crosslinked materials showed some fluctuations, with a maximum mass loss of approximately 7.28%. PBF/HEMA scaffolds supported enhanced MC3T3-E1 cell proliferation while exhibiting low cytotoxicity, indicating favorable biocompatibility. These results indicate that the synthesized PBF/HEMA materials exhibit good biocompatibility and are suitable for biomedical applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Materials Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10853-026-12208-x
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 7108
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      – SubjectFull: Medical polymers
        Type: general
      – SubjectFull: Material biodegradation
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      – SubjectFull: Biocompatibility
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      – SubjectFull: Thermal properties
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      – SubjectFull: Methacrylates
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      – SubjectFull: Biodegradable plastics
        Type: general
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      – TitleFull: Preparation, characterization and in vitro degradation performance of poly (butylene fumarate)-based materials.
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            NameFull: Wang, Liang
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            NameFull: Han, Jiaxin
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            NameFull: Cao, Yongping
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            NameFull: Ren, Siqian
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            NameFull: Ma, Yidan
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              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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