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Solid phase microextraction with liquid chromatography–electrospray ionization–tandem mass spectrometry for analysis of amphetamine and methamphetamine in serum

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Title: Solid phase microextraction with liquid chromatography–electrospray ionization–tandem mass spectrometry for analysis of amphetamine and methamphetamine in serum
Authors: Chou, Chi-Chi1, Lee, Maw-Rong mrlee@mail.nchu.edu.tw
Source: Analytica Chimica Acta. May2005, Vol. 538 Issue 1/2, p49-56. 8p.
Subjects: Serum, Amphetamines, Chromatographic analysis, Spectrum analysis
Abstract: Abstract: This investigation evaluates solid phase microextraction (SPME) combined with liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS) to determine trace levels of amphetamine (AM) and methamphetamine (MA) in serum. Chromatography was performed on a C18 reversed-phase column using a linear gradient of acetonitrile–water as a mobile phase. Using sample extraction by SPME at optimum conditions, analytes were desorbed with static desorption in SPME–HPLC desorption chamber for 1min and then determined with LC–ESI–MS/MS. The detection limits for amphetamine and methamphetamine in serum were 0.3μg/L and 0.04μg/L, respectively. According to the analysis, the linearity range is from 0.5μg/L to 200μg/L with R.S.D. values below 8%. The feasibility of applying the methods to determine amphetamine and methamphetamine in real samples was examined by analyzing serum samples from methamphetamine abused suspects. [Copyright &y& Elsevier]
Copyright of Analytica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 19175469
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Solid phase microextraction with liquid chromatography–electrospray ionization–tandem mass spectrometry for analysis of amphetamine and methamphetamine in serum
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  Data: <searchLink fieldCode="AR" term="%22Chou%2C+Chi-Chi%22">Chou, Chi-Chi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Maw-Rong%22">Lee, Maw-Rong</searchLink><i> mrlee@mail.nchu.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Analytica+Chimica+Acta%22">Analytica Chimica Acta</searchLink>. May2005, Vol. 538 Issue 1/2, p49-56. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Serum%22">Serum</searchLink><br /><searchLink fieldCode="DE" term="%22Amphetamines%22">Amphetamines</searchLink><br /><searchLink fieldCode="DE" term="%22Chromatographic+analysis%22">Chromatographic analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Spectrum+analysis%22">Spectrum analysis</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Abstract: This investigation evaluates solid phase microextraction (SPME) combined with liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS/MS) to determine trace levels of amphetamine (AM) and methamphetamine (MA) in serum. Chromatography was performed on a C18 reversed-phase column using a linear gradient of acetonitrile–water as a mobile phase. Using sample extraction by SPME at optimum conditions, analytes were desorbed with static desorption in SPME–HPLC desorption chamber for 1min and then determined with LC–ESI–MS/MS. The detection limits for amphetamine and methamphetamine in serum were 0.3μg/L and 0.04μg/L, respectively. According to the analysis, the linearity range is from 0.5μg/L to 200μg/L with R.S.D. values below 8%. The feasibility of applying the methods to determine amphetamine and methamphetamine in real samples was examined by analyzing serum samples from methamphetamine abused suspects. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Analytica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.aca.2005.02.018
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      – Code: eng
        Text: English
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        PageCount: 8
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      – SubjectFull: Serum
        Type: general
      – SubjectFull: Amphetamines
        Type: general
      – SubjectFull: Chromatographic analysis
        Type: general
      – SubjectFull: Spectrum analysis
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      – TitleFull: Solid phase microextraction with liquid chromatography–electrospray ionization–tandem mass spectrometry for analysis of amphetamine and methamphetamine in serum
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