Quantitative Mechanophysical Correlations Governing Antibacterial Performance of Amoxicillin-Loaded Poly(ε-caprolactone)/Poly(ethylene glycol) Biodegradable Electrospun Nanofibrous Wound Dressing.
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| Title: | Quantitative Mechanophysical Correlations Governing Antibacterial Performance of Amoxicillin-Loaded Poly(ε-caprolactone)/Poly(ethylene glycol) Biodegradable Electrospun Nanofibrous Wound Dressing. |
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| Authors: | Younes, Husam M.1,2,3 (AUTHOR), Ali Adib, Sandi1,2 (AUTHOR), Salama, Mai1,3,4 (AUTHOR), Adel, Hala1,4 (AUTHOR), Ghanim, Sarah1,4,5 (AUTHOR), Alshaibi, Samaher1,4,6 (AUTHOR), Kadavil, Hana1 (AUTHOR), Nasrallah, Gheyath K.2,5 (AUTHOR), Elkhalifa, Dana1,3,6 (AUTHOR), Al Shammaa, Aya1,4 (AUTHOR) |
| Source: | Polymers (20734360). Feb2026, Vol. 18 Issue 4, p449. 25p. |
| Subjects: | Polycaprolactone, Polyethylene glycol, Mechanical behavior of materials, Surgical dressings, Amoxicillin, Antibacterial agents |
| Abstract: | Biodegradable electrospun nanofibrous scaffolds (BENS) have emerged as a highly advanced class of wound dressings owing to their close structural and morphological resemblance to the native extracellular matrix and their tunable physicochemical and mechanical characteristics. However, the successful translation of electrospun wound-healing platforms from laboratory concepts to clinically viable products necessitates a quantitative understanding of how formulation and processing variables dictate scaffold architecture, mechanical performance, and antibacterial functionality. In this study, hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG35000) were blended at different weight ratios and fabricated into electrospun nanofibrous scaffolds, with amoxicillin trihydrate (AMX) incorporated as a model antibacterial agent. Blank and drug-loaded systems were systematically characterized with respect to solution rheology, fiber morphology, thermal behavior, crystallinity, mechanical performance, surface wettability, and antibacterial activity. Quantitative correlation analyses and statistical comparisons revealed that solution viscosity is a strong predictor of mechanical response, while PEG fraction governs baseline stiffness and crystallinity in a non-linear manner. AMX loading acted as a secondary structural modifier, producing statistically significant increases in stiffness and wettability, accompanied by reduced crystallinity and concentration-dependent antibacterial efficacy. Among the investigated formulations, a PCL: PEG ratio of 3:1 provided the most balanced mechanophysical profile for effective drug incorporation. These findings establish validated structure–property–function relationships that support the rational design of electrospun antibacterial wound dressings. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 192034281 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quantitative Mechanophysical Correlations Governing Antibacterial Performance of Amoxicillin-Loaded Poly(ε-caprolactone)/Poly(ethylene glycol) Biodegradable Electrospun Nanofibrous Wound Dressing. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Younes%2C+Husam+M%2E%22">Younes, Husam M.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali+Adib%2C+Sandi%22">Ali Adib, Sandi</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salama%2C+Mai%22">Salama, Mai</searchLink><relatesTo>1,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adel%2C+Hala%22">Adel, Hala</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghanim%2C+Sarah%22">Ghanim, Sarah</searchLink><relatesTo>1,4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alshaibi%2C+Samaher%22">Alshaibi, Samaher</searchLink><relatesTo>1,4,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kadavil%2C+Hana%22">Kadavil, Hana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nasrallah%2C+Gheyath+K%2E%22">Nasrallah, Gheyath K.</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elkhalifa%2C+Dana%22">Elkhalifa, Dana</searchLink><relatesTo>1,3,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Al+Shammaa%2C+Aya%22">Al Shammaa, Aya</searchLink><relatesTo>1,4</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Feb2026, Vol. 18 Issue 4, p449. 25p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethylene+glycol%22">Polyethylene glycol</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+dressings%22">Surgical dressings</searchLink><br /><searchLink fieldCode="DE" term="%22Amoxicillin%22">Amoxicillin</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Biodegradable electrospun nanofibrous scaffolds (BENS) have emerged as a highly advanced class of wound dressings owing to their close structural and morphological resemblance to the native extracellular matrix and their tunable physicochemical and mechanical characteristics. However, the successful translation of electrospun wound-healing platforms from laboratory concepts to clinically viable products necessitates a quantitative understanding of how formulation and processing variables dictate scaffold architecture, mechanical performance, and antibacterial functionality. In this study, hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG35000) were blended at different weight ratios and fabricated into electrospun nanofibrous scaffolds, with amoxicillin trihydrate (AMX) incorporated as a model antibacterial agent. Blank and drug-loaded systems were systematically characterized with respect to solution rheology, fiber morphology, thermal behavior, crystallinity, mechanical performance, surface wettability, and antibacterial activity. Quantitative correlation analyses and statistical comparisons revealed that solution viscosity is a strong predictor of mechanical response, while PEG fraction governs baseline stiffness and crystallinity in a non-linear manner. AMX loading acted as a secondary structural modifier, producing statistically significant increases in stiffness and wettability, accompanied by reduced crystallinity and concentration-dependent antibacterial efficacy. Among the investigated formulations, a PCL: PEG ratio of 3:1 provided the most balanced mechanophysical profile for effective drug incorporation. These findings establish validated structure–property–function relationships that support the rational design of electrospun antibacterial wound dressings. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym18040449 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 25 StartPage: 449 Subjects: – SubjectFull: Polycaprolactone Type: general – SubjectFull: Polyethylene glycol Type: general – SubjectFull: Mechanical behavior of materials Type: general – SubjectFull: Surgical dressings Type: general – SubjectFull: Amoxicillin Type: general – SubjectFull: Antibacterial agents Type: general Titles: – TitleFull: Quantitative Mechanophysical Correlations Governing Antibacterial Performance of Amoxicillin-Loaded Poly(ε-caprolactone)/Poly(ethylene glycol) Biodegradable Electrospun Nanofibrous Wound Dressing. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Younes, Husam M. – PersonEntity: Name: NameFull: Ali Adib, Sandi – PersonEntity: Name: NameFull: Salama, Mai – PersonEntity: Name: NameFull: Adel, Hala – PersonEntity: Name: NameFull: Ghanim, Sarah – PersonEntity: Name: NameFull: Alshaibi, Samaher – PersonEntity: Name: NameFull: Kadavil, Hana – PersonEntity: Name: NameFull: Nasrallah, Gheyath K. – PersonEntity: Name: NameFull: Elkhalifa, Dana – PersonEntity: Name: NameFull: Al Shammaa, Aya IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 02 Text: Feb2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 18 – Type: issue Value: 4 Titles: – TitleFull: Polymers (20734360) Type: main |
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