The Pneumoconiosis Renaissance: Revisiting the Pulmonary Pathology of Poorly Soluble Low Toxicity Particles: Insights from Rodent Inhalation Studies on Titanium Dioxide Nanoparticles.
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| Title: | The Pneumoconiosis Renaissance: Revisiting the Pulmonary Pathology of Poorly Soluble Low Toxicity Particles: Insights from Rodent Inhalation Studies on Titanium Dioxide Nanoparticles. |
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| Authors: | Yamano, Shotaro1 (AUTHOR) shotaro-yamano@pulmpath.com, Schaudien, Dirk2 (AUTHOR), Umeda, Yumi1 (AUTHOR) |
| Source: | Nanomaterials (2079-4991). Feb2026, Vol. 16 Issue 4, p230. 25p. |
| Subjects: | Titanium dioxide nanoparticles, Pulmonary fibrosis, Toxicity testing, Dust diseases, Lung diseases, Vascular remodeling, Experimental toxicology |
| Abstract: | Historically, the toxicological evaluation of poorly soluble low toxicity particles (PSLTs), such as titanium dioxide nanoparticles (TiO2 NPs), distinct from conventional pigment-grade TiO2, has focused on carcinogenicity and lung overload, leaving their pathological function in the development of pneumoconiosis undefined. In this study, we initiated a "Pneumoconiosis Renaissance", redefining the human "Gold Standard" of pneumoconiosis pathology as a primarily interstitial "Dust Macule (DM) to Mixed Dust Fibrosis (MDF) axis". In contrast, rats developed a species-specific "Airspace-Dominant Phenotype" (Pulmonary Dust Foci) driven by airspace stagnation. Integrating recent continuous inhalation exposure and recovery after inhalation exposure studies, we demonstrate that this overwhelming alveolar pathology in rats acts as a "Biological Mask", physically superimposing upon and obscuring human-relevant interstitial sequestration. Crucially, however, extended recovery periods can unmask these interstitial events, revealing the true underlying pathology. We propose that future risk assessments and Adverse Outcome Pathways (AOPs) must incorporate spatial resolution. By rigorously segregating sensitive rat-specific airspace events from human-relevant interstitial remodeling, we can accurately bridge the interspecies gap. This review argues that rather than discarding the rat model, we must learn to decode it—using spatial distinctions to filter the airspace mask and evaluate the true interstitial risk of inhaled biodurable particles. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 192039947 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Pneumoconiosis Renaissance: Revisiting the Pulmonary Pathology of Poorly Soluble Low Toxicity Particles: Insights from Rodent Inhalation Studies on Titanium Dioxide Nanoparticles. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yamano%2C+Shotaro%22">Yamano, Shotaro</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> shotaro-yamano@pulmpath.com</i><br /><searchLink fieldCode="AR" term="%22Schaudien%2C+Dirk%22">Schaudien, Dirk</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Umeda%2C+Yumi%22">Umeda, Yumi</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. Feb2026, Vol. 16 Issue 4, p230. 25p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Titanium+dioxide+nanoparticles%22">Titanium dioxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+fibrosis%22">Pulmonary fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Toxicity+testing%22">Toxicity testing</searchLink><br /><searchLink fieldCode="DE" term="%22Dust+diseases%22">Dust diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+diseases%22">Lung diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+remodeling%22">Vascular remodeling</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+toxicology%22">Experimental toxicology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Historically, the toxicological evaluation of poorly soluble low toxicity particles (PSLTs), such as titanium dioxide nanoparticles (TiO2 NPs), distinct from conventional pigment-grade TiO2, has focused on carcinogenicity and lung overload, leaving their pathological function in the development of pneumoconiosis undefined. In this study, we initiated a "Pneumoconiosis Renaissance", redefining the human "Gold Standard" of pneumoconiosis pathology as a primarily interstitial "Dust Macule (DM) to Mixed Dust Fibrosis (MDF) axis". In contrast, rats developed a species-specific "Airspace-Dominant Phenotype" (Pulmonary Dust Foci) driven by airspace stagnation. Integrating recent continuous inhalation exposure and recovery after inhalation exposure studies, we demonstrate that this overwhelming alveolar pathology in rats acts as a "Biological Mask", physically superimposing upon and obscuring human-relevant interstitial sequestration. Crucially, however, extended recovery periods can unmask these interstitial events, revealing the true underlying pathology. We propose that future risk assessments and Adverse Outcome Pathways (AOPs) must incorporate spatial resolution. By rigorously segregating sensitive rat-specific airspace events from human-relevant interstitial remodeling, we can accurately bridge the interspecies gap. This review argues that rather than discarding the rat model, we must learn to decode it—using spatial distinctions to filter the airspace mask and evaluate the true interstitial risk of inhaled biodurable particles. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano16040230 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 25 StartPage: 230 Subjects: – SubjectFull: Titanium dioxide nanoparticles Type: general – SubjectFull: Pulmonary fibrosis Type: general – SubjectFull: Toxicity testing Type: general – SubjectFull: Dust diseases Type: general – SubjectFull: Lung diseases Type: general – SubjectFull: Vascular remodeling Type: general – SubjectFull: Experimental toxicology Type: general Titles: – TitleFull: The Pneumoconiosis Renaissance: Revisiting the Pulmonary Pathology of Poorly Soluble Low Toxicity Particles: Insights from Rodent Inhalation Studies on Titanium Dioxide Nanoparticles. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yamano, Shotaro – PersonEntity: Name: NameFull: Schaudien, Dirk – PersonEntity: Name: NameFull: Umeda, Yumi IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 02 Text: Feb2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 16 – Type: issue Value: 4 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
