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Repeatability of Rapid Human Cardiac Phosphorus MRSI (31P‐MRSI) Using Concentric Ring Trajectory Readouts at 7 T.

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Title: Repeatability of Rapid Human Cardiac Phosphorus MRSI (31P‐MRSI) Using Concentric Ring Trajectory Readouts at 7 T.
Authors: Mózes, Ferenc E.1 (AUTHOR), Clarke, William T.2 (AUTHOR), Tyler, Andrew3 (AUTHOR), Karkouri, Jabrane4 (AUTHOR), Niess, Fabian5 (AUTHOR), Miller, Jack J. J. J.6,7 (AUTHOR), Rodgers, Christopher T.4 (AUTHOR), Bogner, Wolfgang5 (AUTHOR), Valkovič, Ladislav1,8 (AUTHOR) ladislav.valkovic@cardiov.ox.ac.uk
Source: Magnetic Resonance in Medicine. May2026, Vol. 95 Issue 5, p2508-2514. 7p.
Subjects: Spectroscopic imaging, Statistical reliability, Biomarkers, Nuclear magnetic resonance spectroscopy, Heart metabolism, Magnetic resonance microscopy
Abstract: Purpose: PCr/ATP ratio is determined at 7 T typically using Fourier‐transform based magnetic resonance spectroscopic imaging sequences (FT‐MRSI). These sequences require acquisition times longer than desirable for inclusion in cardiac clinical trials. Concentric ring trajectory (CRT‐MRSI) has been described as an accelerated alternative k‐space sampling method. In this work we aim to establish the inter‐ and intra‐session repeatability of three different CRT protocols and compare their voxel‐based PCr/ATP ratios to compartment‐based PCr/ATP values extracted with spectroscopy using a linear algebraic model (SLAM) method. Methods: Seven healthy volunteers were scanned twice on two different days. Each time a 6.5‐min 3D FT‐MRSI acquisition with 10 × 10 × 10 resolution was followed by a 2.5‐min CRT‐MRSI with matched resolution, a 1.5‐min CRT‐MRSI with matched resolution, and a 6.9‐min CRT‐MRSI with 12 × 12 × 12 resolution. Spectra from a mid‐septal voxel and the cardiac compartment were fitted with the OXSA toolbox. PCr/ATP ratio was quantified for inter‐ and intra‐session repeatability analysis. Results: Paired repeated measurements were not significantly different within subjects. Good inter‐ and intra‐session agreement was observed between FT‐MRSI and each CRT‐MRSI protocol. CRT‐MRSI protocols all had larger coefficients of repeatability (CoR) than FT‐MRSI. CRT‐SLAM‐based PCr/ATP values had lower CoR than voxel‐based data except for 2.5‐min CRT‐SLAM, and high‐resolution CRT‐SLAM had lower inter‐session CoR compared to FT‐MRSI (1.42 vs. 2.21). Conclusion: We established the repeatability of CRT‐MRSI‐based PCr/ATP values and showed higher SNR and lower CoR for CRT‐SLAM. Our findings allow shorter 31P MRS acquisition times and the use of more advanced energetics‐probing techniques in clinical studies. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Repeatability of Rapid Human Cardiac Phosphorus MRSI (<superscript>31</superscript>P‐MRSI) Using Concentric Ring Trajectory Readouts at 7 T.
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  Data: <searchLink fieldCode="AR" term="%22Mózes%2C+Ferenc+E%2E%22">Mózes, Ferenc E.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clarke%2C+William+T%2E%22">Clarke, William T.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tyler%2C+Andrew%22">Tyler, Andrew</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karkouri%2C+Jabrane%22">Karkouri, Jabrane</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Niess%2C+Fabian%22">Niess, Fabian</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miller%2C+Jack+J%2E+J%2E+J%2E%22">Miller, Jack J. J. J.</searchLink><relatesTo>6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodgers%2C+Christopher+T%2E%22">Rodgers, Christopher T.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bogner%2C+Wolfgang%22">Bogner, Wolfgang</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valkovič%2C+Ladislav%22">Valkovič, Ladislav</searchLink><relatesTo>1,8</relatesTo> (AUTHOR)<i> ladislav.valkovic@cardiov.ox.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. May2026, Vol. 95 Issue 5, p2508-2514. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Spectroscopic+imaging%22">Spectroscopic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+reliability%22">Statistical reliability</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+metabolism%22">Heart metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+microscopy%22">Magnetic resonance microscopy</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose: PCr/ATP ratio is determined at 7 T typically using Fourier‐transform based magnetic resonance spectroscopic imaging sequences (FT‐MRSI). These sequences require acquisition times longer than desirable for inclusion in cardiac clinical trials. Concentric ring trajectory (CRT‐MRSI) has been described as an accelerated alternative k‐space sampling method. In this work we aim to establish the inter‐ and intra‐session repeatability of three different CRT protocols and compare their voxel‐based PCr/ATP ratios to compartment‐based PCr/ATP values extracted with spectroscopy using a linear algebraic model (SLAM) method. Methods: Seven healthy volunteers were scanned twice on two different days. Each time a 6.5‐min 3D FT‐MRSI acquisition with 10 × 10 × 10 resolution was followed by a 2.5‐min CRT‐MRSI with matched resolution, a 1.5‐min CRT‐MRSI with matched resolution, and a 6.9‐min CRT‐MRSI with 12 × 12 × 12 resolution. Spectra from a mid‐septal voxel and the cardiac compartment were fitted with the OXSA toolbox. PCr/ATP ratio was quantified for inter‐ and intra‐session repeatability analysis. Results: Paired repeated measurements were not significantly different within subjects. Good inter‐ and intra‐session agreement was observed between FT‐MRSI and each CRT‐MRSI protocol. CRT‐MRSI protocols all had larger coefficients of repeatability (CoR) than FT‐MRSI. CRT‐SLAM‐based PCr/ATP values had lower CoR than voxel‐based data except for 2.5‐min CRT‐SLAM, and high‐resolution CRT‐SLAM had lower inter‐session CoR compared to FT‐MRSI (1.42 vs. 2.21). Conclusion: We established the repeatability of CRT‐MRSI‐based PCr/ATP values and showed higher SNR and lower CoR for CRT‐SLAM. Our findings allow shorter 31P MRS acquisition times and the use of more advanced energetics‐probing techniques in clinical studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.70220
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      – Code: eng
        Text: English
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        PageCount: 7
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      – SubjectFull: Spectroscopic imaging
        Type: general
      – SubjectFull: Statistical reliability
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      – SubjectFull: Biomarkers
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      – SubjectFull: Nuclear magnetic resonance spectroscopy
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      – SubjectFull: Heart metabolism
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      – SubjectFull: Magnetic resonance microscopy
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      – TitleFull: Repeatability of Rapid Human Cardiac Phosphorus MRSI (31P‐MRSI) Using Concentric Ring Trajectory Readouts at 7 T.
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              Text: May2026
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              Y: 2026
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