Optimization of Calcined Bone Powder and Silane-Crosslinked Alginate Composites for Enhanced Mechanical Performance as a Cortical Bone Substitute.
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| Title: | Optimization of Calcined Bone Powder and Silane-Crosslinked Alginate Composites for Enhanced Mechanical Performance as a Cortical Bone Substitute. |
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| Authors: | Tanaka, Shigeo M.1 (AUTHOR) shigeo@se.kanazawa-u.ac.jp |
| Source: | Annals of Biomedical Engineering. Mar2026, Vol. 54 Issue 3, p796-803. 8p. |
| Subjects: | Compact bone, Composite materials, Hydroxyapatite, Biocompatibility, Mechanical behavior of materials, Nanoparticles, Bone substitutes |
| Abstract: | Purpose: Developing bone substitute materials that mimic both trabecular and cortical bone remains a major challenge due to the trade-off between bio- and mechano-compatibility, particularly in naturally derived materials. While composites of calcined bone powder and silane-crosslinked alginate exhibit good biocompatibility and mechanical properties resembling those of trabecular bone, their mechanical properties remain insufficient for cortical bone applications. Methods: This study explores a strategy to address this limitation by optimizing the composite formulation through blending ratio adjustment and nanoparticulation of calcined bone powder. Cylindrical composites (φ 15 mm × h 8 mm) were fabricated by varying the ratios of calcined bone powder (average particle size 246 μm), alginate, and silane cross-linking agent. Results: Increasing the alginate ratio 10-fold (B/A10-Si) relative to the original formulation (B/A-Si) led to significant increases in elastic modulus, maximum stress, and strain energy which were further improved with the addition of a reduced amount of silane agent (B/A10-Si1/10). Additional enhancement was achieved using nanoparticulated bone powder (average particle size 651 nm), leading to further increases in modulus, strength, and energy by factors of 2.4, 1.7, and 1.4 respectively, compared to B/A10-Si1/10. Overall, the elastic modulus, maximum stress, and strain energy improved 8.4-fold, 18-fold, and 11-fold compared to B/A-Si, approaching values characteristic of cortical bone. Conclusion: These findings suggest that combining blending optimization with nanoparticulation is a promising strategy to enhance the mechanical performance of naturally derived composites and may expand their applicability to cortical bone replacement. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 192095220 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Optimization of Calcined Bone Powder and Silane-Crosslinked Alginate Composites for Enhanced Mechanical Performance as a Cortical Bone Substitute. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tanaka%2C+Shigeo+M%2E%22">Tanaka, Shigeo M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> shigeo@se.kanazawa-u.ac.jp</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Mar2026, Vol. 54 Issue 3, p796-803. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Compact+bone%22">Compact bone</searchLink><br /><searchLink fieldCode="DE" term="%22Composite+materials%22">Composite materials</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyapatite%22">Hydroxyapatite</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+substitutes%22">Bone substitutes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Developing bone substitute materials that mimic both trabecular and cortical bone remains a major challenge due to the trade-off between bio- and mechano-compatibility, particularly in naturally derived materials. While composites of calcined bone powder and silane-crosslinked alginate exhibit good biocompatibility and mechanical properties resembling those of trabecular bone, their mechanical properties remain insufficient for cortical bone applications. Methods: This study explores a strategy to address this limitation by optimizing the composite formulation through blending ratio adjustment and nanoparticulation of calcined bone powder. Cylindrical composites (φ 15 mm × h 8 mm) were fabricated by varying the ratios of calcined bone powder (average particle size 246 μm), alginate, and silane cross-linking agent. Results: Increasing the alginate ratio 10-fold (B/A10-Si) relative to the original formulation (B/A-Si) led to significant increases in elastic modulus, maximum stress, and strain energy which were further improved with the addition of a reduced amount of silane agent (B/A10-Si1/10). Additional enhancement was achieved using nanoparticulated bone powder (average particle size 651 nm), leading to further increases in modulus, strength, and energy by factors of 2.4, 1.7, and 1.4 respectively, compared to B/A10-Si1/10. Overall, the elastic modulus, maximum stress, and strain energy improved 8.4-fold, 18-fold, and 11-fold compared to B/A-Si, approaching values characteristic of cortical bone. Conclusion: These findings suggest that combining blending optimization with nanoparticulation is a promising strategy to enhance the mechanical performance of naturally derived composites and may expand their applicability to cortical bone replacement. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-025-03924-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 796 Subjects: – SubjectFull: Compact bone Type: general – SubjectFull: Composite materials Type: general – SubjectFull: Hydroxyapatite Type: general – SubjectFull: Biocompatibility Type: general – SubjectFull: Mechanical behavior of materials Type: general – SubjectFull: Nanoparticles Type: general – SubjectFull: Bone substitutes Type: general Titles: – TitleFull: Optimization of Calcined Bone Powder and Silane-Crosslinked Alginate Composites for Enhanced Mechanical Performance as a Cortical Bone Substitute. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tanaka, Shigeo M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 54 – Type: issue Value: 3 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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