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Application of PLCL as a biodegradable polymer in biomedical engineering.

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Title: Application of PLCL as a biodegradable polymer in biomedical engineering.
Authors: Zhao, Yonggang1 (AUTHOR) zyg@jshb.gov.cn, Liu, Honglei2 (AUTHOR)
Source: Journal of Materials Science: Materials in Medicine. 2/27/2026, Vol. 37 Issue 1, p1-36. 36p.
Subjects: Biomedical engineering, Polycaprolactone, Nervous system regeneration, Wound healing, Surgical stents, Drug delivery systems, Biodegradable plastics, Tissue engineering
Abstract: Poly (L-lactide-co-ε-caprolactone) (PLCL) is a novel polymer that has attracted considerable attention in the biomedical field due to its exceptional biocompatibility. However, a comprehensive and systematic summary of its diverse applications remains lacking. To address this gap, the present review outlines the physicochemical properties of PLCL and the factors that influence them. Additionally, it consolidates the most commonly employed processing and preparation methods for PLCL in biomedical applications. The review further provides a systematic overview of current applications of PLCL in various biomedical fields, including wound healing, cardiovascular stents, nerve repair, osteochondral tissue engineering, drug delivery, and screening. It also examines modification strategies aimed at enhancing PLCL performance. Ultimately, this review seeks to provide valuable insights for future research and development of PLCL in biomedical contexts. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Application of PLCL as a biodegradable polymer in biomedical engineering.
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  Data: <searchLink fieldCode="AR" term="%22Zhao%2C+Yonggang%22">Zhao, Yonggang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zyg@jshb.gov.cn</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Honglei%22">Liu, Honglei</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Materials+Science%3A+Materials+in+Medicine%22">Journal of Materials Science: Materials in Medicine</searchLink>. 2/27/2026, Vol. 37 Issue 1, p1-36. 36p.
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  Data: <searchLink fieldCode="DE" term="%22Biomedical+engineering%22">Biomedical engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system+regeneration%22">Nervous system regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+stents%22">Surgical stents</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradable+plastics%22">Biodegradable plastics</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Poly (L-lactide-co-ε-caprolactone) (PLCL) is a novel polymer that has attracted considerable attention in the biomedical field due to its exceptional biocompatibility. However, a comprehensive and systematic summary of its diverse applications remains lacking. To address this gap, the present review outlines the physicochemical properties of PLCL and the factors that influence them. Additionally, it consolidates the most commonly employed processing and preparation methods for PLCL in biomedical applications. The review further provides a systematic overview of current applications of PLCL in various biomedical fields, including wound healing, cardiovascular stents, nerve repair, osteochondral tissue engineering, drug delivery, and screening. It also examines modification strategies aimed at enhancing PLCL performance. Ultimately, this review seeks to provide valuable insights for future research and development of PLCL in biomedical contexts. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s10856-026-07016-3
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      – Code: eng
        Text: English
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        PageCount: 36
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      – SubjectFull: Biomedical engineering
        Type: general
      – SubjectFull: Polycaprolactone
        Type: general
      – SubjectFull: Nervous system regeneration
        Type: general
      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Surgical stents
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      – SubjectFull: Drug delivery systems
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      – SubjectFull: Biodegradable plastics
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      – SubjectFull: Tissue engineering
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            NameFull: Zhao, Yonggang
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            NameFull: Liu, Honglei
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            – D: 27
              M: 02
              Text: 2/27/2026
              Type: published
              Y: 2026
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