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Engineering optimization of ozone generation technologies for medical device sterilization: a review.

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Title: Engineering optimization of ozone generation technologies for medical device sterilization: a review.
Authors: Setiadhi, David1 (AUTHOR) 512110012@ogr.uludag.edu.tr, Çavdar, Kadir2 (AUTHOR), Özakın, Cüneyt3 (AUTHOR), Ayas, Kadir1 (AUTHOR)
Source: Journal of Physics D: Applied Physics. 2026, Vol. 59 Issue 9, p1-32. 32p.
Subjects: Corona discharge, Ozone generators, Disinfection & disinfectants, Sterilization (Disinfection), Sterilization equipment
Abstract: Ozone is increasingly recognized as an alternative sterilization agent for medical devices, offering high oxidative potential, broad-spectrum antimicrobial activity, and residue-free decomposition. Despite these advantages, its broader adoption remains constrained by ozone's chemical instability and sensitivity to environmental conditions, complicating consistent sterilization outcomes, particularly for heat-sensitive devices and those with complex geometries. This review provides a critical evaluation of the four main ozone generation technologies used in medical device sterilization: corona discharge (CD), dielectric barrier discharge (DBD), ultraviolet-induced generation (UV-C), and electrochemical ozone production (EOP). The analysis focuses on how environmental parameters, material interactions, and reactor configurations influence ozone stability, delivery precision, and disinfection efficacy. Comparative findings indicate that while DBD systems provide superior energy efficiency and ozone yield, they require further optimization to mitigate NOx formation and manage thermal instability. CD systems, although widely used, face similar challenges and lower overall efficiency. EOP systems offer safer, NOx-free ozone generation but are limited by low output efficiency and scalability. UV-C systems, although contributing to ozone production through photodissociation, remain best suited as adjuncts in hybrid sterilization platforms. This review highlights key engineering strategies, identifies critical knowledge gaps, and outlines future research directions to advance ozone-based sterilization toward safe, efficient, and clinically relevant applications. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Physics D: Applied Physics is the property of IOP Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 192160239
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Engineering optimization of ozone generation technologies for medical device sterilization: a review.
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  Data: <searchLink fieldCode="AR" term="%22Setiadhi%2C+David%22">Setiadhi, David</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> 512110012@ogr.uludag.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Çavdar%2C+Kadir%22">Çavdar, Kadir</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Özakın%2C+Cüneyt%22">Özakın, Cüneyt</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ayas%2C+Kadir%22">Ayas, Kadir</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Physics+D%3A+Applied+Physics%22">Journal of Physics D: Applied Physics</searchLink>. 2026, Vol. 59 Issue 9, p1-32. 32p.
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  Data: <searchLink fieldCode="DE" term="%22Corona+discharge%22">Corona discharge</searchLink><br /><searchLink fieldCode="DE" term="%22Ozone+generators%22">Ozone generators</searchLink><br /><searchLink fieldCode="DE" term="%22Disinfection+%26+disinfectants%22">Disinfection & disinfectants</searchLink><br /><searchLink fieldCode="DE" term="%22Sterilization+%28Disinfection%29%22">Sterilization (Disinfection)</searchLink><br /><searchLink fieldCode="DE" term="%22Sterilization+equipment%22">Sterilization equipment</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Ozone is increasingly recognized as an alternative sterilization agent for medical devices, offering high oxidative potential, broad-spectrum antimicrobial activity, and residue-free decomposition. Despite these advantages, its broader adoption remains constrained by ozone's chemical instability and sensitivity to environmental conditions, complicating consistent sterilization outcomes, particularly for heat-sensitive devices and those with complex geometries. This review provides a critical evaluation of the four main ozone generation technologies used in medical device sterilization: corona discharge (CD), dielectric barrier discharge (DBD), ultraviolet-induced generation (UV-C), and electrochemical ozone production (EOP). The analysis focuses on how environmental parameters, material interactions, and reactor configurations influence ozone stability, delivery precision, and disinfection efficacy. Comparative findings indicate that while DBD systems provide superior energy efficiency and ozone yield, they require further optimization to mitigate NOx formation and manage thermal instability. CD systems, although widely used, face similar challenges and lower overall efficiency. EOP systems offer safer, NOx-free ozone generation but are limited by low output efficiency and scalability. UV-C systems, although contributing to ozone production through photodissociation, remain best suited as adjuncts in hybrid sterilization platforms. This review highlights key engineering strategies, identifies critical knowledge gaps, and outlines future research directions to advance ozone-based sterilization toward safe, efficient, and clinically relevant applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Physics D: Applied Physics is the property of IOP Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1088/1361-6463/ae38f1
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      – Code: eng
        Text: English
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        PageCount: 32
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      – SubjectFull: Corona discharge
        Type: general
      – SubjectFull: Ozone generators
        Type: general
      – SubjectFull: Disinfection & disinfectants
        Type: general
      – SubjectFull: Sterilization (Disinfection)
        Type: general
      – SubjectFull: Sterilization equipment
        Type: general
    Titles:
      – TitleFull: Engineering optimization of ozone generation technologies for medical device sterilization: a review.
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            NameFull: Çavdar, Kadir
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            NameFull: Özakın, Cüneyt
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            NameFull: Ayas, Kadir
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            – D: 06
              M: 03
              Text: 2026
              Type: published
              Y: 2026
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            – TitleFull: Journal of Physics D: Applied Physics
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