Diode and er: YAG laser therapy versus other desensitizing treatments for dentin hypersensitivity in molar-incisor hypomineralization: a systematic review.

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Title: Diode and er: YAG laser therapy versus other desensitizing treatments for dentin hypersensitivity in molar-incisor hypomineralization: a systematic review.
Authors: Cappellaro, Eliane Cardoso1 (AUTHOR) eliane.cappellaro@ufrgs.br, Ribeiro, Jéssica Fogliato1 (AUTHOR) jessicafr.odonto@gmail.com, da Silva, Carolina Lopes1 (AUTHOR) silvacarollopes@gmail.com, Cavalheiro, Cleber Paradzinski1 (AUTHOR) clebe.r@hotmail.com, Martins, Manoela Domingues1 (AUTHOR) manomartins@gmail.com, Lenzi, Tathiane Larissa1 (AUTHOR) tathiane.lenzi@ufrgs.br
Source: Lasers in Medical Science. 3/12/2026, Vol. 41 Issue 1, p1-10. 10p.
Subjects: YAG lasers, Tooth sensitivity, Clinical trials, Developmental defects of enamel, Semiconductor lasers
Abstract: This study investigated the use of laser therapy for dentin hypersensitivity (DH) in patients with molar-incisor hypomineralization (MIH), compared with other desensitizing treatments. A systematic search was performed in electronic databases: PubMed, Scopus, LILACS, Embase, and Web of Science. Additionally, trial registries (ClinicalTrials.gov and ReBEC), grey literature, and manual search were checked. Two reviewers independently performed study selection, data extraction, and risk of bias assessment using the RoB 2 tool. Given the heterogeneity in included studies, only a descriptive analysis was undertaken. From 2,450 potentially eligible studies, three randomized clinical trials were selected for full-text analysis, and included. These studies comprising 462 MIH-affected molars and incisors in patients aged 6–14 years. Follow-up ranged from 1 to 6 months. Interventions included diode lasers (808 nm, 980 nm) and a low-power Er: YAG protocol (0.4 W, 40 mJ, 10 Hz), compared with fluoride varnish, GLUMA desensitizer, or CPP-ACPF mousse. All studies reported DH reduction across groups; however, no statistically significant differences were observed between laser and other desensitizing treatments. Two studies were rated as high risk of bias, and one showed some concerns. Available evidence remains limited and heterogeneous due to few included studies and an overall fragile evidence base, indicating that laser therapy may reduce DH in MIH-affected teeth. Well-designed and standardized randomized clinical trials are still needed to strengthen the evidence base. (PROSPERO registration: CRD42024608626). [ABSTRACT FROM AUTHOR]
Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Diode and er: YAG laser therapy versus other desensitizing treatments for dentin hypersensitivity in molar-incisor hypomineralization: a systematic review.
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  Data: <searchLink fieldCode="AR" term="%22Cappellaro%2C+Eliane+Cardoso%22">Cappellaro, Eliane Cardoso</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> eliane.cappellaro@ufrgs.br</i><br /><searchLink fieldCode="AR" term="%22Ribeiro%2C+Jéssica+Fogliato%22">Ribeiro, Jéssica Fogliato</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> jessicafr.odonto@gmail.com</i><br /><searchLink fieldCode="AR" term="%22da+Silva%2C+Carolina+Lopes%22">da Silva, Carolina Lopes</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> silvacarollopes@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Cavalheiro%2C+Cleber+Paradzinski%22">Cavalheiro, Cleber Paradzinski</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> clebe.r@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Martins%2C+Manoela+Domingues%22">Martins, Manoela Domingues</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> manomartins@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Lenzi%2C+Tathiane+Larissa%22">Lenzi, Tathiane Larissa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> tathiane.lenzi@ufrgs.br</i>
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  Data: <searchLink fieldCode="JN" term="%22Lasers+in+Medical+Science%22">Lasers in Medical Science</searchLink>. 3/12/2026, Vol. 41 Issue 1, p1-10. 10p.
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  Data: <searchLink fieldCode="DE" term="%22YAG+lasers%22">YAG lasers</searchLink><br /><searchLink fieldCode="DE" term="%22Tooth+sensitivity%22">Tooth sensitivity</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Developmental+defects+of+enamel%22">Developmental defects of enamel</searchLink><br /><searchLink fieldCode="DE" term="%22Semiconductor+lasers%22">Semiconductor lasers</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study investigated the use of laser therapy for dentin hypersensitivity (DH) in patients with molar-incisor hypomineralization (MIH), compared with other desensitizing treatments. A systematic search was performed in electronic databases: PubMed, Scopus, LILACS, Embase, and Web of Science. Additionally, trial registries (ClinicalTrials.gov and ReBEC), grey literature, and manual search were checked. Two reviewers independently performed study selection, data extraction, and risk of bias assessment using the RoB 2 tool. Given the heterogeneity in included studies, only a descriptive analysis was undertaken. From 2,450 potentially eligible studies, three randomized clinical trials were selected for full-text analysis, and included. These studies comprising 462 MIH-affected molars and incisors in patients aged 6–14 years. Follow-up ranged from 1 to 6 months. Interventions included diode lasers (808 nm, 980 nm) and a low-power Er: YAG protocol (0.4 W, 40 mJ, 10 Hz), compared with fluoride varnish, GLUMA desensitizer, or CPP-ACPF mousse. All studies reported DH reduction across groups; however, no statistically significant differences were observed between laser and other desensitizing treatments. Two studies were rated as high risk of bias, and one showed some concerns. Available evidence remains limited and heterogeneous due to few included studies and an overall fragile evidence base, indicating that laser therapy may reduce DH in MIH-affected teeth. Well-designed and standardized randomized clinical trials are still needed to strengthen the evidence base. (PROSPERO registration: CRD42024608626). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Lasers in Medical Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Diode and er: YAG laser therapy versus other desensitizing treatments for dentin hypersensitivity in molar-incisor hypomineralization: a systematic review.
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              Text: 3/12/2026
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