Impact of E‐Beam Sterilization on Bioglass Composite Shape Memory Scaffolds.
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| Title: | Impact of E‐Beam Sterilization on Bioglass Composite Shape Memory Scaffolds. |
|---|---|
| Authors: | Nitschke, Brandon M.1 (AUTHOR), Wahby, MaryGrace N.1 (AUTHOR), Grunlan, Melissa A.1,2,3 (AUTHOR) mgrunlan@tamu.edu |
| Source: | Macromolecular Materials & Engineering. Mar2026, Vol. 311 Issue 3, p1-10. 10p. |
| Subjects: | Shape memory polymers, Bioactive glasses, Polymers, Hydroxyapatite, Electron beams, Polycaprolactone, Craniofacial abnormalities |
| Abstract: | A "self‐fitting" bioactive composite scaffold based on a shape memory polymer (SMP) and 45S5 Bioglass (BG) offers a promising regenerative treatment for irregularly shaped craniomaxillofacial (CMF) bone defects. Self‐fitting is afforded by scaffolds prepared as crosslinked networks from linear‐poly(ε‐caprolactone)‐diacrylate (linear‐PCL‐DA), and as semi‐interpenetrating networks (semi‐IPNs) with the inclusion of thermoplastic linear‐poly(L‐lactic acid) (linear‐PLLA) (75:25 wt.%). Composites may be formed by inclusion of bioactive BG (5 and 10 wt.%) to elicit hydroxyapatite (HAp) mineralization and to increase degradation rates. To advance their clinical translation, such scaffolds must be conducive to modern sterilization methods. Electron beam (E‐beam) sterilization is an attractive alternative to conventional methods (e.g., ethylene oxide). Herein, the effect of E‐beam sterilization (25 kGy) on SMP composite scaffolds and non‐composite controls was systematically assessed. Sterilized scaffolds largely preserved the PCL crosslinked network (i.e., similar sol contents) as well as pore features. The compressive mechanical behavior of sterilized scaffolds was also largely maintained. E‐beam sterilization caused minor changes in PCL crystallinity, but excellent shape memory behavior was retained. In vitro degradation was somewhat faster following sterilization for scaffolds containing 10 wt.% BG. All E‐beam sterilized composite scaffolds retained bioactivity, exhibiting HAp mineralization with exposure to simulated body fluid (SBF, 1X). [ABSTRACT FROM AUTHOR] |
| Copyright of Macromolecular Materials & Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 192630335 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Impact of E‐Beam Sterilization on Bioglass Composite Shape Memory Scaffolds. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nitschke%2C+Brandon+M%2E%22">Nitschke, Brandon M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wahby%2C+MaryGrace+N%2E%22">Wahby, MaryGrace N.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grunlan%2C+Melissa+A%2E%22">Grunlan, Melissa A.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> mgrunlan@tamu.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Macromolecular+Materials+%26+Engineering%22">Macromolecular Materials & Engineering</searchLink>. Mar2026, Vol. 311 Issue 3, p1-10. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Shape+memory+polymers%22">Shape memory polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Bioactive+glasses%22">Bioactive glasses</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyapatite%22">Hydroxyapatite</searchLink><br /><searchLink fieldCode="DE" term="%22Electron+beams%22">Electron beams</searchLink><br /><searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Craniofacial+abnormalities%22">Craniofacial abnormalities</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: A "self‐fitting" bioactive composite scaffold based on a shape memory polymer (SMP) and 45S5 Bioglass (BG) offers a promising regenerative treatment for irregularly shaped craniomaxillofacial (CMF) bone defects. Self‐fitting is afforded by scaffolds prepared as crosslinked networks from linear‐poly(ε‐caprolactone)‐diacrylate (linear‐PCL‐DA), and as semi‐interpenetrating networks (semi‐IPNs) with the inclusion of thermoplastic linear‐poly(L‐lactic acid) (linear‐PLLA) (75:25 wt.%). Composites may be formed by inclusion of bioactive BG (5 and 10 wt.%) to elicit hydroxyapatite (HAp) mineralization and to increase degradation rates. To advance their clinical translation, such scaffolds must be conducive to modern sterilization methods. Electron beam (E‐beam) sterilization is an attractive alternative to conventional methods (e.g., ethylene oxide). Herein, the effect of E‐beam sterilization (25 kGy) on SMP composite scaffolds and non‐composite controls was systematically assessed. Sterilized scaffolds largely preserved the PCL crosslinked network (i.e., similar sol contents) as well as pore features. The compressive mechanical behavior of sterilized scaffolds was also largely maintained. E‐beam sterilization caused minor changes in PCL crystallinity, but excellent shape memory behavior was retained. In vitro degradation was somewhat faster following sterilization for scaffolds containing 10 wt.% BG. All E‐beam sterilized composite scaffolds retained bioactivity, exhibiting HAp mineralization with exposure to simulated body fluid (SBF, 1X). [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Macromolecular Materials & Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mame.202500329 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: Shape memory polymers Type: general – SubjectFull: Bioactive glasses Type: general – SubjectFull: Polymers Type: general – SubjectFull: Hydroxyapatite Type: general – SubjectFull: Electron beams Type: general – SubjectFull: Polycaprolactone Type: general – SubjectFull: Craniofacial abnormalities Type: general Titles: – TitleFull: Impact of E‐Beam Sterilization on Bioglass Composite Shape Memory Scaffolds. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nitschke, Brandon M. – PersonEntity: Name: NameFull: Wahby, MaryGrace N. – PersonEntity: Name: NameFull: Grunlan, Melissa A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 14387492 Numbering: – Type: volume Value: 311 – Type: issue Value: 3 Titles: – TitleFull: Macromolecular Materials & Engineering Type: main |
| ResultId | 1 |
