Quaternized Chitosan Crosslinked Networks for pH-Responsive Macromolecule Delivery: A Review.
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| Title: | Quaternized Chitosan Crosslinked Networks for pH-Responsive Macromolecule Delivery: A Review. |
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| Authors: | Wang, Tongtong1,2 (AUTHOR), Sun, Hui1,2 (AUTHOR) sunhui@th.btbu.edu.cn |
| Source: | Polymers (20734360). Mar2026, Vol. 18 Issue 5, p649. 36p. |
| Subjects: | Crosslinked polymers, Targeted drug delivery, Packaging design, Chitosan, Antibacterial agents, Polysaccharides, Polymer networks |
| Abstract: | Chitosan, a biocompatible and biodegradable polysaccharide, exhibits notable antibacterial properties. However, its practical applications are often constrained by inherent limitations such as poor solubility (restricted to acidic media) and suboptimal mechanical strength. By constructing dynamic covalent networks with QCS and green crosslinkers (e.g., genipin, dialdehyde cellulose), materials acquire excellent pH-responsive intelligence. This review elaborates on the molecular design, crosslinking strategies, and applications in intelligent packaging and targeted therapy. The synergistic Schiff-base/hydrogen-bonding mechanism enables dual (pH/enzyme) responsive release. We clarify the relationship between quaternization degree and cytotoxicity as a key challenge for clinical translation and analyze how green crosslinkers are molecular bridges to tailor network properties. The 'perception-response' integrated design principle of QCS demonstrates significant potential for intelligent packaging and antibacterial−anticancer synergistic therapy, while addressing key biosafety considerations. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 192641950 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quaternized Chitosan Crosslinked Networks for pH-Responsive Macromolecule Delivery: A Review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Tongtong%22">Wang, Tongtong</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Hui%22">Sun, Hui</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> sunhui@th.btbu.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Mar2026, Vol. 18 Issue 5, p649. 36p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Crosslinked+polymers%22">Crosslinked polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Packaging+design%22">Packaging design</searchLink><br /><searchLink fieldCode="DE" term="%22Chitosan%22">Chitosan</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Polymer+networks%22">Polymer networks</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Chitosan, a biocompatible and biodegradable polysaccharide, exhibits notable antibacterial properties. However, its practical applications are often constrained by inherent limitations such as poor solubility (restricted to acidic media) and suboptimal mechanical strength. By constructing dynamic covalent networks with QCS and green crosslinkers (e.g., genipin, dialdehyde cellulose), materials acquire excellent pH-responsive intelligence. This review elaborates on the molecular design, crosslinking strategies, and applications in intelligent packaging and targeted therapy. The synergistic Schiff-base/hydrogen-bonding mechanism enables dual (pH/enzyme) responsive release. We clarify the relationship between quaternization degree and cytotoxicity as a key challenge for clinical translation and analyze how green crosslinkers are molecular bridges to tailor network properties. The 'perception-response' integrated design principle of QCS demonstrates significant potential for intelligent packaging and antibacterial−anticancer synergistic therapy, while addressing key biosafety considerations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym18050649 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 36 StartPage: 649 Subjects: – SubjectFull: Crosslinked polymers Type: general – SubjectFull: Targeted drug delivery Type: general – SubjectFull: Packaging design Type: general – SubjectFull: Chitosan Type: general – SubjectFull: Antibacterial agents Type: general – SubjectFull: Polysaccharides Type: general – SubjectFull: Polymer networks Type: general Titles: – TitleFull: Quaternized Chitosan Crosslinked Networks for pH-Responsive Macromolecule Delivery: A Review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Tongtong – PersonEntity: Name: NameFull: Sun, Hui IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 18 – Type: issue Value: 5 Titles: – TitleFull: Polymers (20734360) Type: main |
| ResultId | 1 |
