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Efficient ozonolysis of steroids via electrochemical ozone production coupled with microchannel reactor.

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Title: Efficient ozonolysis of steroids via electrochemical ozone production coupled with microchannel reactor.
Authors: Ding, Yang1 (AUTHOR), Dong, Zhenyang1 (AUTHOR), Zhou, Hailiang2 (AUTHOR), Li, Kai1 (AUTHOR), Guo, Wei1 (AUTHOR), Wang, Yuhang1 (AUTHOR), Liu, Lihao1 (AUTHOR), Yi, Zujiang1 (AUTHOR), Zhang, Zhengbin2 (AUTHOR) zhengbin.zhang@junyepharm.com, Zhong, Xing1 (AUTHOR) zhongx@zjut.edu.cn, Wang, Jianguo1 (AUTHOR)
Source: AIChE Journal. May2026, Vol. 72 Issue 5, p1-15. 15p.
Subjects: Ozonolysis, Ozone generators, Pharmaceutical chemicals manufacturing, Continuous processing, Computational fluid dynamics, Steroids, Microreactors, Mass transfer
Abstract: Ozonolysis offers a clean and selective route for CC bond cleavage, but conventional processes suffer from ozonide explosion hazards and poor mass transfer. Here, we integrate electrochemical ozone production (EOP) with continuous‐flow microchannel ozonolysis for the safe conversion of steroid substrates. A dual surfactant modified β‐PbO2 electrocatalyst (β‐PbO2‐CP) in a self‐developed ozone electrolyzer achieved high ozone generation efficiency with over 750 h stability. Precision‐engineered microchannel reactor intensified gas–liquid transfer via microscale bubble dynamics, affording 91.3% conversion and 98.1% selectivity for 17α‐methyltestosterone, which achieved a 33.7‐fold increase in space–time yield vs. batch reactor. Computational fluid dynamics (CFD) simulations revealed electrothermal flow modeling showed 42.6% lower peak temperature with 98.9% prediction accuracy in the ozone electrolyzer and elucidated gas–liquid behavior in microchannel reactor. This integrated platform demonstrates a controlled continuous‐flow approach suitable for pharmaceutical manufacturing, highlighting the potential of coupling EOP with flow chemistry for industrial oxidative processes. [ABSTRACT FROM AUTHOR]
Copyright of AIChE Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 192785647
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Efficient ozonolysis of steroids via electrochemical ozone production coupled with microchannel reactor.
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  Data: <searchLink fieldCode="AR" term="%22Ding%2C+Yang%22">Ding, Yang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dong%2C+Zhenyang%22">Dong, Zhenyang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Hailiang%22">Zhou, Hailiang</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Kai%22">Li, Kai</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Wei%22">Guo, Wei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yuhang%22">Wang, Yuhang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Lihao%22">Liu, Lihao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yi%2C+Zujiang%22">Yi, Zujiang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zhengbin%22">Zhang, Zhengbin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> zhengbin.zhang@junyepharm.com</i><br /><searchLink fieldCode="AR" term="%22Zhong%2C+Xing%22">Zhong, Xing</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> zhongx@zjut.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Jianguo%22">Wang, Jianguo</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22AIChE+Journal%22">AIChE Journal</searchLink>. May2026, Vol. 72 Issue 5, p1-15. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Ozonolysis%22">Ozonolysis</searchLink><br /><searchLink fieldCode="DE" term="%22Ozone+generators%22">Ozone generators</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+chemicals+manufacturing%22">Pharmaceutical chemicals manufacturing</searchLink><br /><searchLink fieldCode="DE" term="%22Continuous+processing%22">Continuous processing</searchLink><br /><searchLink fieldCode="DE" term="%22Computational+fluid+dynamics%22">Computational fluid dynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Steroids%22">Steroids</searchLink><br /><searchLink fieldCode="DE" term="%22Microreactors%22">Microreactors</searchLink><br /><searchLink fieldCode="DE" term="%22Mass+transfer%22">Mass transfer</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Ozonolysis offers a clean and selective route for CC bond cleavage, but conventional processes suffer from ozonide explosion hazards and poor mass transfer. Here, we integrate electrochemical ozone production (EOP) with continuous‐flow microchannel ozonolysis for the safe conversion of steroid substrates. A dual surfactant modified β‐PbO2 electrocatalyst (β‐PbO2‐CP) in a self‐developed ozone electrolyzer achieved high ozone generation efficiency with over 750 h stability. Precision‐engineered microchannel reactor intensified gas–liquid transfer via microscale bubble dynamics, affording 91.3% conversion and 98.1% selectivity for 17α‐methyltestosterone, which achieved a 33.7‐fold increase in space–time yield vs. batch reactor. Computational fluid dynamics (CFD) simulations revealed electrothermal flow modeling showed 42.6% lower peak temperature with 98.9% prediction accuracy in the ozone electrolyzer and elucidated gas–liquid behavior in microchannel reactor. This integrated platform demonstrates a controlled continuous‐flow approach suitable for pharmaceutical manufacturing, highlighting the potential of coupling EOP with flow chemistry for industrial oxidative processes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of AIChE Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/aic.70230
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 1
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      – SubjectFull: Ozonolysis
        Type: general
      – SubjectFull: Ozone generators
        Type: general
      – SubjectFull: Pharmaceutical chemicals manufacturing
        Type: general
      – SubjectFull: Continuous processing
        Type: general
      – SubjectFull: Computational fluid dynamics
        Type: general
      – SubjectFull: Steroids
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      – SubjectFull: Microreactors
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      – SubjectFull: Mass transfer
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      – TitleFull: Efficient ozonolysis of steroids via electrochemical ozone production coupled with microchannel reactor.
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              Text: May2026
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