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Self-Assembly of Modular Bis-MPA Dendrons into Colloidal Particles with Tunable Morphology and Selective Cytotoxicity.

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Title: Self-Assembly of Modular Bis-MPA Dendrons into Colloidal Particles with Tunable Morphology and Selective Cytotoxicity.
Authors: Negrón, Luis M.1 (AUTHOR) luis.negron11@upr.edu, Camacho-Mercado, Clara L.2 (AUTHOR), Morales-Borges, Cristian A.1,3 (AUTHOR), López-Colón, Alondra1,4 (AUTHOR), De Jesús-Hernández, Ariana1 (AUTHOR), Santiago-Figueroa, Ansé E.1,2 (AUTHOR), Rodríguez-Rivera, Jean M.3 (AUTHOR), Ferrer-Acosta, Yancy4 (AUTHOR), Madera-Soto, Bismark A.2 (AUTHOR)
Source: Nanomaterials (2079-4991). Apr2026, Vol. 16 Issue 7, p406. 15p.
Subjects: Molecular self-assembly, Colloids, Neuroblastoma, Biocompatibility, Surface structure, Cytotoxins
Abstract: Precise control over the physicochemical and biological properties of colloidal particles is essential for the rational design of functional soft materials. In this work, we report a simple and scalable strategy for generating modular dendron particles (MDPs) through the self-assembly of fully characterized small-molecule Bis-MPA dendrons that act as programmable molecular building blocks for colloidal particle formation. By systematically varying three structural domains—the inner functionality, methylene spacer length, and outer connector—we achieve tunable formation of MDPs ranging from nano- to microscale dimensions. Upon solvent evaporation under mild drying conditions, pre-assembled MDPs act as structure-directing seeds that guide the emergence of hierarchical surface morphologies with spiky, scaly, or spherical protrusions, depending on dendron architecture. Importantly, these assemblies exhibit good biocompatibility toward non-tumoral bronchial epithelial (NL-20) cells while displaying selective cytotoxicity toward Neuro-2a neuroblastoma cells, demonstrating that dendron molecular architecture alone can govern particle size, morphology, and biological response without external drug loading. Collectively, these findings highlight modular Bis-MPA dendrons as versatile building blocks for directing particle size, morphology, and biological response through controlled self-assembly and evaporation-driven structuring. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Self-Assembly of Modular Bis-MPA Dendrons into Colloidal Particles with Tunable Morphology and Selective Cytotoxicity.
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  Data: <searchLink fieldCode="DE" term="%22Molecular+self-assembly%22">Molecular self-assembly</searchLink><br /><searchLink fieldCode="DE" term="%22Colloids%22">Colloids</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroblastoma%22">Neuroblastoma</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+structure%22">Surface structure</searchLink><br /><searchLink fieldCode="DE" term="%22Cytotoxins%22">Cytotoxins</searchLink>
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  Data: Precise control over the physicochemical and biological properties of colloidal particles is essential for the rational design of functional soft materials. In this work, we report a simple and scalable strategy for generating modular dendron particles (MDPs) through the self-assembly of fully characterized small-molecule Bis-MPA dendrons that act as programmable molecular building blocks for colloidal particle formation. By systematically varying three structural domains—the inner functionality, methylene spacer length, and outer connector—we achieve tunable formation of MDPs ranging from nano- to microscale dimensions. Upon solvent evaporation under mild drying conditions, pre-assembled MDPs act as structure-directing seeds that guide the emergence of hierarchical surface morphologies with spiky, scaly, or spherical protrusions, depending on dendron architecture. Importantly, these assemblies exhibit good biocompatibility toward non-tumoral bronchial epithelial (NL-20) cells while displaying selective cytotoxicity toward Neuro-2a neuroblastoma cells, demonstrating that dendron molecular architecture alone can govern particle size, morphology, and biological response without external drug loading. Collectively, these findings highlight modular Bis-MPA dendrons as versatile building blocks for directing particle size, morphology, and biological response through controlled self-assembly and evaporation-driven structuring. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano16070406
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        Text: English
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        PageCount: 15
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      – SubjectFull: Molecular self-assembly
        Type: general
      – SubjectFull: Colloids
        Type: general
      – SubjectFull: Neuroblastoma
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      – SubjectFull: Surface structure
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      – SubjectFull: Cytotoxins
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      – TitleFull: Self-Assembly of Modular Bis-MPA Dendrons into Colloidal Particles with Tunable Morphology and Selective Cytotoxicity.
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              Text: Apr2026
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