View in EDS

Nanoporous Anodized Alumina for Drug Delivery: Design Strategies and Doxorubicin Release Mechanisms.

Saved in:
Bibliographic Details
Title: Nanoporous Anodized Alumina for Drug Delivery: Design Strategies and Doxorubicin Release Mechanisms.
Authors: Wang, Ao1,2 (AUTHOR), Yang, Shumin2 (AUTHOR), Lin, Xuemei2 (AUTHOR), Qi, Yunkai2 (AUTHOR), Shi, Guochao3 (AUTHOR), Yusop, Abdul Hakim Md1 (AUTHOR), Yajid, Muhamad Azizi Mat1 (AUTHOR), Gu, Jianjun2 (AUTHOR) jjungu@126.com, Ali, Wan Fahmin Faiz Wan1 (AUTHOR) wan_fahmin@utm.my
Source: NANO (1793-2920). Jul2026, Vol. 21 Issue 9, p1-16. 16p.
Subjects: Doxorubicin, Nanoporous materials, Pharmaceutical encapsulation, Anodic oxidation of metals, Drug delivery systems, Pore size distribution, Controlled release drugs, Osteosarcoma
Abstract: This study employed an improved anodization process to fabricate nanoporous anodic alumina (NAA) films with various pore parameters for use as drug carriers. Doxorubicin (DOX) was selected as a model drug to investigate drug loading and in vitro release behaviors. The experimental results demonstrated that pore size and morphology significantly influenced the release rate and diffusion behavior of DOX. Specifically, the design of nonstandard pores from top to bottom is 1 2 1. 2 7 ± 1 1. 5 3 nm, 1 5 9. 2 9 ± 2 3. 5 9 nm, and 1 7 9. 3 4 ± 2 1. 1 0 nm, respectively, which can effectively extend the release duration and enhance diffusion performance. Optimizing the pore structure notably improved the drug-loading capacity and controlled-release performance of the NAA. The DOX release kinetics indicated that the NAA-based drug delivery system (DDS) followed a first-order kinetic model. These findings provide a quantitative framework for tuning release behavior through structural design, which may inform the future development of porous platforms for controlled drug delivery. This study has significant implications for the clinical application of intelligent DDSs that utilize NAA as a drug carrier. In this study, funnel-shaped nanoporous anodized aluminum (NAA) membranes with tailored pore sizes (121, 159, and 179 nm) were fabricated using an optimized anodization process. Their efficacy as doxorubicin (DOX) carriers was evaluated, demonstrating that the refined pore architecture significantly enhances drug loading capacity and controlled release kinetics, offering a promising approach for targeted osteosarcoma therapy. [ABSTRACT FROM AUTHOR]
Copyright of NANO (1793-2920) is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 193061872
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Nanoporous Anodized Alumina for Drug Delivery: Design Strategies and Doxorubicin Release Mechanisms.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Ao%22">Wang, Ao</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Shumin%22">Yang, Shumin</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Xuemei%22">Lin, Xuemei</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qi%2C+Yunkai%22">Qi, Yunkai</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shi%2C+Guochao%22">Shi, Guochao</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yusop%2C+Abdul+Hakim+Md%22">Yusop, Abdul Hakim Md</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yajid%2C+Muhamad+Azizi+Mat%22">Yajid, Muhamad Azizi Mat</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gu%2C+Jianjun%22">Gu, Jianjun</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> jjungu@126.com</i><br /><searchLink fieldCode="AR" term="%22Ali%2C+Wan+Fahmin+Faiz+Wan%22">Ali, Wan Fahmin Faiz Wan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> wan_fahmin@utm.my</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22NANO+%281793-2920%29%22">NANO (1793-2920)</searchLink>. Jul2026, Vol. 21 Issue 9, p1-16. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Doxorubicin%22">Doxorubicin</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoporous+materials%22">Nanoporous materials</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+encapsulation%22">Pharmaceutical encapsulation</searchLink><br /><searchLink fieldCode="DE" term="%22Anodic+oxidation+of+metals%22">Anodic oxidation of metals</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Pore+size+distribution%22">Pore size distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Osteosarcoma%22">Osteosarcoma</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study employed an improved anodization process to fabricate nanoporous anodic alumina (NAA) films with various pore parameters for use as drug carriers. Doxorubicin (DOX) was selected as a model drug to investigate drug loading and in vitro release behaviors. The experimental results demonstrated that pore size and morphology significantly influenced the release rate and diffusion behavior of DOX. Specifically, the design of nonstandard pores from top to bottom is 1 2 1. 2 7 ± 1 1. 5 3 nm, 1 5 9. 2 9 ± 2 3. 5 9 nm, and 1 7 9. 3 4 ± 2 1. 1 0 nm, respectively, which can effectively extend the release duration and enhance diffusion performance. Optimizing the pore structure notably improved the drug-loading capacity and controlled-release performance of the NAA. The DOX release kinetics indicated that the NAA-based drug delivery system (DDS) followed a first-order kinetic model. These findings provide a quantitative framework for tuning release behavior through structural design, which may inform the future development of porous platforms for controlled drug delivery. This study has significant implications for the clinical application of intelligent DDSs that utilize NAA as a drug carrier. In this study, funnel-shaped nanoporous anodized aluminum (NAA) membranes with tailored pore sizes (121, 159, and 179 nm) were fabricated using an optimized anodization process. Their efficacy as doxorubicin (DOX) carriers was evaluated, demonstrating that the refined pore architecture significantly enhances drug loading capacity and controlled release kinetics, offering a promising approach for targeted osteosarcoma therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of NANO (1793-2920) is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=193061872
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1142/S1793292025501218
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 1
    Subjects:
      – SubjectFull: Doxorubicin
        Type: general
      – SubjectFull: Nanoporous materials
        Type: general
      – SubjectFull: Pharmaceutical encapsulation
        Type: general
      – SubjectFull: Anodic oxidation of metals
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Pore size distribution
        Type: general
      – SubjectFull: Controlled release drugs
        Type: general
      – SubjectFull: Osteosarcoma
        Type: general
    Titles:
      – TitleFull: Nanoporous Anodized Alumina for Drug Delivery: Design Strategies and Doxorubicin Release Mechanisms.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wang, Ao
      – PersonEntity:
          Name:
            NameFull: Yang, Shumin
      – PersonEntity:
          Name:
            NameFull: Lin, Xuemei
      – PersonEntity:
          Name:
            NameFull: Qi, Yunkai
      – PersonEntity:
          Name:
            NameFull: Shi, Guochao
      – PersonEntity:
          Name:
            NameFull: Yusop, Abdul Hakim Md
      – PersonEntity:
          Name:
            NameFull: Yajid, Muhamad Azizi Mat
      – PersonEntity:
          Name:
            NameFull: Gu, Jianjun
      – PersonEntity:
          Name:
            NameFull: Ali, Wan Fahmin Faiz Wan
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 17932920
          Numbering:
            – Type: volume
              Value: 21
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: NANO (1793-2920)
              Type: main
ResultId 1