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FABP7 controls radial glial scaffold stability during human cortical development.

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Title: FABP7 controls radial glial scaffold stability during human cortical development.
Authors: Wang, Yuanhao1,2, Zhang, Xu1,2, Ba, Ru3, Zhu, Yimin1, Yu, Hanwen1, Wang, Da1, Chu, Chu1, Zhang, Xinyue1,2, Hong, Yuan1,4, Wu, Shanshan1, Zhu, Wanying1, Xu, Min1, Cheng, Qing5 chengq@njmu.edu.cn, Zhao, Chunjie3,6 zhaocj@seu.edu.cn, Han, Xiao1,2,4 xhan1988@njmu.edu.cn, Liu, Yan1,2,4 yanliu@njmu.edu.cn
Source: Proceedings of the National Academy of Sciences of the United States of America. 4/21/2026, Vol. 123 Issue 16, p1-11. 11p.
Subjects: Fatty acid-binding proteins, Cerebral cortex development, Cell migration, Neuroglia, Autism, Cytoskeleton, Neural development
Abstract: Radial glial (RG) cells serve as both neural progenitors and structural scaffolds for neuronal migration during cortical development. Although FABP7 has long been recognized as a marker of RG cells, its regulatory function has remained poorly defined. Using human fetal brain slices, embryonic mouse model, cerebral organoids, and assembloids, we demonstrate that FABP7 is essential for maintaining RG scaffold architecture and coordinating neuronal positioning. Single-cell analysis revealed that FABP7 deficiency induces transcriptional dysregulation, particularly affecting cytoskeletal organization, neural fate specification, and stress responses. Furthermore, transcriptomic features in FABP7 knockdown organoids exhibit convergence with neurodevelopmental disorders such as autism, alongside recapitulation of scaffold defects observed in idiopathic autism organoids. Mechanistically, FABP7 loss suppresses the mevalonate (MVA) pathway, resulting in impaired GTPase-mediated cytoskeletal organization and disruption of radial scaffold integrity. These findings identify FABP7 as a key regulator of cortical development and disease-relevant molecular programs, linking metabolic signaling to neurodevelopmental vulnerability. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 193223398
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
  Group: Ti
  Data: FABP7 controls radial glial scaffold stability during human cortical development.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Yuanhao%22">Wang, Yuanhao</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xu%22">Zhang, Xu</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ba%2C+Ru%22">Ba, Ru</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Yimin%22">Zhu, Yimin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yu%2C+Hanwen%22">Yu, Hanwen</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wang%2C+Da%22">Wang, Da</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chu%2C+Chu%22">Chu, Chu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xinyue%22">Zhang, Xinyue</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hong%2C+Yuan%22">Hong, Yuan</searchLink><relatesTo>1,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Wu%2C+Shanshan%22">Wu, Shanshan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Wanying%22">Zhu, Wanying</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Min%22">Xu, Min</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Qing%22">Cheng, Qing</searchLink><relatesTo>5</relatesTo><i> chengq@njmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Chunjie%22">Zhao, Chunjie</searchLink><relatesTo>3,6</relatesTo><i> zhaocj@seu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Han%2C+Xiao%22">Han, Xiao</searchLink><relatesTo>1,2,4</relatesTo><i> xhan1988@njmu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Yan%22">Liu, Yan</searchLink><relatesTo>1,2,4</relatesTo><i> yanliu@njmu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 4/21/2026, Vol. 123 Issue 16, p1-11. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Fatty+acid-binding+proteins%22">Fatty acid-binding proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+cortex+development%22">Cerebral cortex development</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+migration%22">Cell migration</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroglia%22">Neuroglia</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Cytoskeleton%22">Cytoskeleton</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Radial glial (RG) cells serve as both neural progenitors and structural scaffolds for neuronal migration during cortical development. Although FABP7 has long been recognized as a marker of RG cells, its regulatory function has remained poorly defined. Using human fetal brain slices, embryonic mouse model, cerebral organoids, and assembloids, we demonstrate that FABP7 is essential for maintaining RG scaffold architecture and coordinating neuronal positioning. Single-cell analysis revealed that FABP7 deficiency induces transcriptional dysregulation, particularly affecting cytoskeletal organization, neural fate specification, and stress responses. Furthermore, transcriptomic features in FABP7 knockdown organoids exhibit convergence with neurodevelopmental disorders such as autism, alongside recapitulation of scaffold defects observed in idiopathic autism organoids. Mechanistically, FABP7 loss suppresses the mevalonate (MVA) pathway, resulting in impaired GTPase-mediated cytoskeletal organization and disruption of radial scaffold integrity. These findings identify FABP7 as a key regulator of cortical development and disease-relevant molecular programs, linking metabolic signaling to neurodevelopmental vulnerability. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1073/pnas.2523130123
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 1
    Subjects:
      – SubjectFull: Fatty acid-binding proteins
        Type: general
      – SubjectFull: Cerebral cortex development
        Type: general
      – SubjectFull: Cell migration
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      – SubjectFull: Neuroglia
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      – SubjectFull: Autism
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      – SubjectFull: Cytoskeleton
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      – SubjectFull: Neural development
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      – TitleFull: FABP7 controls radial glial scaffold stability during human cortical development.
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            NameFull: Wang, Yuanhao
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              Text: 4/21/2026
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              Y: 2026
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            – TitleFull: Proceedings of the National Academy of Sciences of the United States of America
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