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Analysis of isothiazolinones and other preservatives in leather, synthetic leather, and textile products available in Japan.

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Title: Analysis of isothiazolinones and other preservatives in leather, synthetic leather, and textile products available in Japan.
Authors: Mori, Yoko1 (AUTHOR) yoko-mori@nihs.go.jp, Kawakami, Tsuyoshi1 (AUTHOR), Tahara, Maiko1 (AUTHOR), Kawano, Sachie1 (AUTHOR), Uchiyama, Nahoko1 (AUTHOR)
Source: Journal of Environmental Science & Health. Part A. Toxic/Hazardous Substances & Environmental Engineering. 2026, Vol. 61 Issue 5, p328-334. 7p.
Subjects: Leather, Contact dermatitis, Isothiazole, Food preservatives, Product safety, Analytical chemistry, Textile products, Leather goods
Geographic Terms: Japan
Abstract: Isothiazolinone-based preservatives have recently emerged as notable contributors to non-occupational allergic contact dermatitis (ACD). However, comprehensive data on their prevalence and concentrations in consumer products with prolonged skin contact remain limited. This study aimed to quantify 12 preservatives, including various isothiazolinones, in leather, synthetic leather, and textile products available in Japan. Notably, 2-n-octyl-4-isothiazolin-3-one (OIT), 2-methyl-4-isothiazolin-3-one (MI), and 1,2-benzisothiazolin-3-one were frequently detected in leather and synthetic leather, with some of these products containing relatively high concentrations of OIT (up to 150 µg/g). These levels were comparable to those observed in cases of ACD associated with OIT-containing leather. Other preservatives, such as 4-chloro-3-methylphenol, 2-(thiocyanomethylthio)benzothiazole, and o-phenylphenol, were also found in several products. In textiles, only low concentrations of MI, triclosan, and triclocarban were detected. Although there has been no significant increase in ACD cases related to these preservatives in Japan to date, continuous monitoring of their usage and associated clinical outcomes is essential. The findings of this study highlight the importance of monitoring the preservatives used in products that come into direct and prolonged contact with the skin. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Environmental Science & Health. Part A. Toxic/Hazardous Substances & Environmental Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 193364627
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Analysis of isothiazolinones and other preservatives in leather, synthetic leather, and textile products available in Japan.
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  Data: <searchLink fieldCode="AR" term="%22Mori%2C+Yoko%22">Mori, Yoko</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yoko-mori@nihs.go.jp</i><br /><searchLink fieldCode="AR" term="%22Kawakami%2C+Tsuyoshi%22">Kawakami, Tsuyoshi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tahara%2C+Maiko%22">Tahara, Maiko</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kawano%2C+Sachie%22">Kawano, Sachie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Uchiyama%2C+Nahoko%22">Uchiyama, Nahoko</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Leather%22">Leather</searchLink><br /><searchLink fieldCode="DE" term="%22Contact+dermatitis%22">Contact dermatitis</searchLink><br /><searchLink fieldCode="DE" term="%22Isothiazole%22">Isothiazole</searchLink><br /><searchLink fieldCode="DE" term="%22Food+preservatives%22">Food preservatives</searchLink><br /><searchLink fieldCode="DE" term="%22Product+safety%22">Product safety</searchLink><br /><searchLink fieldCode="DE" term="%22Analytical+chemistry%22">Analytical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Textile+products%22">Textile products</searchLink><br /><searchLink fieldCode="DE" term="%22Leather+goods%22">Leather goods</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Japan%22">Japan</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Isothiazolinone-based preservatives have recently emerged as notable contributors to non-occupational allergic contact dermatitis (ACD). However, comprehensive data on their prevalence and concentrations in consumer products with prolonged skin contact remain limited. This study aimed to quantify 12 preservatives, including various isothiazolinones, in leather, synthetic leather, and textile products available in Japan. Notably, 2-n-octyl-4-isothiazolin-3-one (OIT), 2-methyl-4-isothiazolin-3-one (MI), and 1,2-benzisothiazolin-3-one were frequently detected in leather and synthetic leather, with some of these products containing relatively high concentrations of OIT (up to 150 µg/g). These levels were comparable to those observed in cases of ACD associated with OIT-containing leather. Other preservatives, such as 4-chloro-3-methylphenol, 2-(thiocyanomethylthio)benzothiazole, and o-phenylphenol, were also found in several products. In textiles, only low concentrations of MI, triclosan, and triclocarban were detected. Although there has been no significant increase in ACD cases related to these preservatives in Japan to date, continuous monitoring of their usage and associated clinical outcomes is essential. The findings of this study highlight the importance of monitoring the preservatives used in products that come into direct and prolonged contact with the skin. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Environmental Science & Health. Part A. Toxic/Hazardous Substances & Environmental Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=193364627
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/10934529.2026.2646066
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 328
    Subjects:
      – SubjectFull: Leather
        Type: general
      – SubjectFull: Contact dermatitis
        Type: general
      – SubjectFull: Isothiazole
        Type: general
      – SubjectFull: Food preservatives
        Type: general
      – SubjectFull: Product safety
        Type: general
      – SubjectFull: Analytical chemistry
        Type: general
      – SubjectFull: Textile products
        Type: general
      – SubjectFull: Leather goods
        Type: general
      – SubjectFull: Japan
        Type: general
    Titles:
      – TitleFull: Analysis of isothiazolinones and other preservatives in leather, synthetic leather, and textile products available in Japan.
        Type: main
  BibRelationships:
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          Name:
            NameFull: Mori, Yoko
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            NameFull: Kawakami, Tsuyoshi
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            NameFull: Tahara, Maiko
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            NameFull: Kawano, Sachie
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            NameFull: Uchiyama, Nahoko
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          Dates:
            – D: 01
              M: 05
              Text: 2026
              Type: published
              Y: 2026
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              Value: 10934529
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              Value: 61
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Journal of Environmental Science & Health. Part A. Toxic/Hazardous Substances & Environmental Engineering
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