Functional Versatility of Sulfonamide-pyrazole Derivative: From Antibacterial Activity to Metal ion Sensing Aptitude.
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| Title: | Functional Versatility of Sulfonamide-pyrazole Derivative: From Antibacterial Activity to Metal ion Sensing Aptitude. |
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| Authors: | Garg, Ankita1 (AUTHOR), Garg, Neha1 (AUTHOR), Dhiman, Rajat1 (AUTHOR), Chaudhary, Savita1 (AUTHOR) schaudhary@pu.ac.in, Bhalla, Aman1 (AUTHOR) amanbhalla@pu.ac.in |
| Source: | Journal of Fluorescence. Apr2026, Vol. 36 Issue 4, p3123-3133. 11p. |
| Subjects: | Antibacterial agents, Pyrazolyl compounds, Ion analysis, Biosensors, Sulfone derivatives, Molecular docking, Ions |
| Abstract: | In this study, a novel sulfonamide-Schiff base derivative, ethyl (Z)-2-(5-chloro-3-methyl-4-((2-tosylhydrazono) methyl)-1H-pyrazol-1-yl)acetate 6, was synthesized to address sulfonamide resistance and explore its therapeutic potential. The molecular structure was confirmed through comprehensive spectroscopic analyses including FT-IR, 1H & 13C NMR and mass spectrometry, providing strong evidence for the proposed architecture. Antibacterial evaluation revealed that compound 6 pyrazole exhibited notable antibacterial activity against Staphylococcus aureus (inhibition zones up to 1.2 mm), with comparatively moderate activity against Escherichia coli (0.6–0.7 mm). Molecular docking studies demonstrated pronounced binding affinities toward DNA gyrase and β-lactamase, corroborating its observed antibacterial efficacy and suggesting promising therapeutic relevance. Notably, the compound also displayed sensitive and selective chemosensing for Fe3+ (0.27 µM) and Fe2+ (0.12 µM), highlighting its multifunctional profile as both a potent antibacterial agent and a metal ion sensor. These findings indicate that compound 6 is a multifunctional bioactive scaffold and represents a promising lead for further investigation in antimicrobial and chemosensing applications. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Fluorescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 193390794 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Functional Versatility of Sulfonamide-pyrazole Derivative: From Antibacterial Activity to Metal ion Sensing Aptitude. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Garg%2C+Ankita%22">Garg, Ankita</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garg%2C+Neha%22">Garg, Neha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dhiman%2C+Rajat%22">Dhiman, Rajat</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chaudhary%2C+Savita%22">Chaudhary, Savita</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> schaudhary@pu.ac.in</i><br /><searchLink fieldCode="AR" term="%22Bhalla%2C+Aman%22">Bhalla, Aman</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> amanbhalla@pu.ac.in</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Fluorescence%22">Journal of Fluorescence</searchLink>. Apr2026, Vol. 36 Issue 4, p3123-3133. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Pyrazolyl+compounds%22">Pyrazolyl compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+analysis%22">Ion analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink><br /><searchLink fieldCode="DE" term="%22Sulfone+derivatives%22">Sulfone derivatives</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+docking%22">Molecular docking</searchLink><br /><searchLink fieldCode="DE" term="%22Ions%22">Ions</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In this study, a novel sulfonamide-Schiff base derivative, ethyl (Z)-2-(5-chloro-3-methyl-4-((2-tosylhydrazono) methyl)-1H-pyrazol-1-yl)acetate 6, was synthesized to address sulfonamide resistance and explore its therapeutic potential. The molecular structure was confirmed through comprehensive spectroscopic analyses including FT-IR, 1H & 13C NMR and mass spectrometry, providing strong evidence for the proposed architecture. Antibacterial evaluation revealed that compound 6 pyrazole exhibited notable antibacterial activity against Staphylococcus aureus (inhibition zones up to 1.2 mm), with comparatively moderate activity against Escherichia coli (0.6–0.7 mm). Molecular docking studies demonstrated pronounced binding affinities toward DNA gyrase and β-lactamase, corroborating its observed antibacterial efficacy and suggesting promising therapeutic relevance. Notably, the compound also displayed sensitive and selective chemosensing for Fe3+ (0.27 µM) and Fe2+ (0.12 µM), highlighting its multifunctional profile as both a potent antibacterial agent and a metal ion sensor. These findings indicate that compound 6 is a multifunctional bioactive scaffold and represents a promising lead for further investigation in antimicrobial and chemosensing applications. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Fluorescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10895-026-04751-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 3123 Subjects: – SubjectFull: Antibacterial agents Type: general – SubjectFull: Pyrazolyl compounds Type: general – SubjectFull: Ion analysis Type: general – SubjectFull: Biosensors Type: general – SubjectFull: Sulfone derivatives Type: general – SubjectFull: Molecular docking Type: general – SubjectFull: Ions Type: general Titles: – TitleFull: Functional Versatility of Sulfonamide-pyrazole Derivative: From Antibacterial Activity to Metal ion Sensing Aptitude. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Garg, Ankita – PersonEntity: Name: NameFull: Garg, Neha – PersonEntity: Name: NameFull: Dhiman, Rajat – PersonEntity: Name: NameFull: Chaudhary, Savita – PersonEntity: Name: NameFull: Bhalla, Aman IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 10530509 Numbering: – Type: volume Value: 36 – Type: issue Value: 4 Titles: – TitleFull: Journal of Fluorescence Type: main |
| ResultId | 1 |
