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Mitochondrial targeting of growth suppressor protein DLC2 through the START domain

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Title: Mitochondrial targeting of growth suppressor protein DLC2 through the START domain
Authors: Ng, David Chi-Heng1, Chan, Shing-Fai1, Kok, Kin Hang1, Yam, Judy Wai Ping1,2, Ching, Yick-Pang1,2, Ng, Irene Oi-lin2, Jin, Dong-Yan1 dyjin@hkucc.hku.hk
Source: FEBS Letters. Jan2006, Vol. 580 Issue 1, p191-198. 8p.
Subjects: Tumor suppressor proteins, Tumor suppressor genes, Liver cancer, Blood plasma
Abstract: Abstract: Deleted in liver cancer 2 (DLC2) is a candidate tumor suppressor frequently found to be deleted in hepatocellular carcinoma. In this study, we determined the subcellular localization of DLC2. Co-localization and biochemical fractionation studies revealed that DLC2 localized to mitochondria. In addition, the DLC2-containing cytoplasmic speckles were in proximity to lipid droplets. A DLC2 mutant containing the steroidogenic acute regulatory protein-related lipid transfer (START) domain only showed a localization pattern identical to that of DLC2. Taken together, we have provided the first evidence for mitochondrial localization of DLC2 through the START domain. These findings might have implications in liver physiology and carcinogenesis. [Copyright &y& Elsevier]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 19339884
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Mitochondrial targeting of growth suppressor protein DLC2 through the START domain
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  Data: <searchLink fieldCode="AR" term="%22Ng%2C+David+Chi-Heng%22">Ng, David Chi-Heng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chan%2C+Shing-Fai%22">Chan, Shing-Fai</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kok%2C+Kin+Hang%22">Kok, Kin Hang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yam%2C+Judy+Wai+Ping%22">Yam, Judy Wai Ping</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ching%2C+Yick-Pang%22">Ching, Yick-Pang</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ng%2C+Irene+Oi-lin%22">Ng, Irene Oi-lin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jin%2C+Dong-Yan%22">Jin, Dong-Yan</searchLink><relatesTo>1</relatesTo><i> dyjin@hkucc.hku.hk</i>
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Jan2006, Vol. 580 Issue 1, p191-198. 8p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Tumor+suppressor+proteins%22">Tumor suppressor proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+suppressor+genes%22">Tumor suppressor genes</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+cancer%22">Liver cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+plasma%22">Blood plasma</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Abstract: Deleted in liver cancer 2 (DLC2) is a candidate tumor suppressor frequently found to be deleted in hepatocellular carcinoma. In this study, we determined the subcellular localization of DLC2. Co-localization and biochemical fractionation studies revealed that DLC2 localized to mitochondria. In addition, the DLC2-containing cytoplasmic speckles were in proximity to lipid droplets. A DLC2 mutant containing the steroidogenic acute regulatory protein-related lipid transfer (START) domain only showed a localization pattern identical to that of DLC2. Taken together, we have provided the first evidence for mitochondrial localization of DLC2 through the START domain. These findings might have implications in liver physiology and carcinogenesis. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.febslet.2005.11.073
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      – Code: eng
        Text: English
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        StartPage: 191
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      – SubjectFull: Tumor suppressor proteins
        Type: general
      – SubjectFull: Tumor suppressor genes
        Type: general
      – SubjectFull: Liver cancer
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      – SubjectFull: Blood plasma
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      – TitleFull: Mitochondrial targeting of growth suppressor protein DLC2 through the START domain
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              Text: Jan2006
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              Y: 2006
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