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Centaurea virgata Lam. Instigates EtOH‐Induced Gastric Toxicity/Ulcer In Vivo: Role of SOD/MDA, Bax/HSP 70, and TNF‐α/IL‐10.

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Title: Centaurea virgata Lam. Instigates EtOH‐Induced Gastric Toxicity/Ulcer In Vivo: Role of SOD/MDA, Bax/HSP 70, and TNF‐α/IL‐10.
Authors: Alqaisi, Khalid M.1 (AUTHOR), Rashid, Essa Qarani2 (AUTHOR), Ismael, Abdulrahman3 (AUTHOR), Jaffar, Hawar Jawdat4 (AUTHOR), Jabbar, Ahmed A. J.4 (AUTHOR) ahmed.abuljabbar@epu.edu.iq, El-Sayyad, Gharieb S.5 (AUTHOR), Alsharif, Hanan Ibrahim6 (AUTHOR), Algefare, Abdulmohsen I.7 (AUTHOR), Alfwuaires, Manal A.7 (AUTHOR), Mohamed, Marwa Yousry A.5 (AUTHOR), Bendif, Hamdi5 (AUTHOR), Al-Qaisi, Talal Salem8 (AUTHOR), Bose, Anupama (AUTHOR) abose@wiley.com
Source: Journal of Food Biochemistry. 5/4/2026, Vol. 2026, p1-16. 16p.
Subjects: Stomach ulcers, Alcoholic intoxication, Tumor necrosis factors, Superoxide dismutase, Malondialdehyde, Centaurea, BAX protein, HSP70 heat-shock proteins
Abstract: Centaurea virgata is broadly used as a traditional food and medicine across the globe for numerous health purposes. Although the species is reported to have antioxidant and anti‐inflammatory activities, literature data on its gastroprotective effects are scarce. Due to numerous shortcomings of conventional anti‐ulcer drugs, natural products gained renewed interest as a safer alternative. This study aimed to investigate the acute toxicity and gastroprotective effects of the aerial part extracts of Centaurea virgata (APCV) on ethanol‐induced gastric ulcers in Sprague–Dawley rats. Rats were divided into 5 groups: normal control, ulcer control (saline + EtOH), reference (lansoprazole + EtOH), APCV 100 mg/kg + EtOH, and APCV 200 mg/kg + EtOH. APCV 100 or 200 mg/kg, administered orally 1 h before the ethanol‐induced ulcer procedure delivery, increased the protective index % (26.82% and 31.40%, respectively). The histopathological results (using H&E and PAS) indicated preserved gastric defense barriers (restored mucus secretion and gastric pH) and tissue architecture as a result of APCV pretreatment. APCV intervention (100 and 200 mg/kg) increased superoxide dismutase by 24.33% and 62.14%; catalase by 59.07% and 90.37%; and upregulated IL‐10 by 24.40% and 79.52%, while significantly (p < 0.01) lowering MDA by 25.97% and 38.77%, as well as significantly (p < 0.001) downregulated IL‐6 by 14.67% and 33.08% and TNF‐α by 37.82% and 47.59%, respectively, compared to ulcer controls. It could also be noted that inhibited apoptosis (inhibited pro‐apoptotic Bax and increased HSP 70 appearances in gastric tissues) occurred in gastric tissues pretreated with APCV. Taken together, APCV exhibited a gastroprotective potential against gastric ulcers, which is attributed to its attenuation effects on oxidative stress, inflammatory, and apoptotic pathways. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Centaurea virgata Lam. Instigates EtOH‐Induced Gastric Toxicity/Ulcer In Vivo: Role of SOD/MDA, Bax/HSP 70, and TNF‐α/IL‐10.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alqaisi%2C+Khalid+M%2E%22&quot;&gt;Alqaisi, Khalid M.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rashid%2C+Essa+Qarani%22&quot;&gt;Rashid, Essa Qarani&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ismael%2C+Abdulrahman%22&quot;&gt;Ismael, Abdulrahman&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jaffar%2C+Hawar+Jawdat%22&quot;&gt;Jaffar, Hawar Jawdat&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jabbar%2C+Ahmed+A%2E+J%2E%22&quot;&gt;Jabbar, Ahmed A. J.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; ahmed.abuljabbar@epu.edu.iq&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22El-Sayyad%2C+Gharieb+S%2E%22&quot;&gt;El-Sayyad, Gharieb S.&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alsharif%2C+Hanan+Ibrahim%22&quot;&gt;Alsharif, Hanan Ibrahim&lt;/searchLink&gt;&lt;relatesTo&gt;6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Algefare%2C+Abdulmohsen+I%2E%22&quot;&gt;Algefare, Abdulmohsen I.&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alfwuaires%2C+Manal+A%2E%22&quot;&gt;Alfwuaires, Manal A.&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mohamed%2C+Marwa+Yousry+A%2E%22&quot;&gt;Mohamed, Marwa Yousry A.&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bendif%2C+Hamdi%22&quot;&gt;Bendif, Hamdi&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Al-Qaisi%2C+Talal+Salem%22&quot;&gt;Al-Qaisi, Talal Salem&lt;/searchLink&gt;&lt;relatesTo&gt;8&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bose%2C+Anupama%22&quot;&gt;Bose, Anupama&lt;/searchLink&gt; (AUTHOR)&lt;i&gt; abose@wiley.com&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Food+Biochemistry%22&quot;&gt;Journal of Food Biochemistry&lt;/searchLink&gt;. 5/4/2026, Vol. 2026, p1-16. 16p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Stomach+ulcers%22&quot;&gt;Stomach ulcers&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Alcoholic+intoxication%22&quot;&gt;Alcoholic intoxication&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Tumor+necrosis+factors%22&quot;&gt;Tumor necrosis factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Superoxide+dismutase%22&quot;&gt;Superoxide dismutase&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Malondialdehyde%22&quot;&gt;Malondialdehyde&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Centaurea%22&quot;&gt;Centaurea&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BAX+protein%22&quot;&gt;BAX protein&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HSP70+heat-shock+proteins%22&quot;&gt;HSP70 heat-shock proteins&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Centaurea virgata is broadly used as a traditional food and medicine across the globe for numerous health purposes. Although the species is reported to have antioxidant and anti‐inflammatory activities, literature data on its gastroprotective effects are scarce. Due to numerous shortcomings of conventional anti‐ulcer drugs, natural products gained renewed interest as a safer alternative. This study aimed to investigate the acute toxicity and gastroprotective effects of the aerial part extracts of Centaurea virgata (APCV) on ethanol‐induced gastric ulcers in Sprague–Dawley rats. Rats were divided into 5 groups: normal control, ulcer control (saline + EtOH), reference (lansoprazole + EtOH), APCV 100 mg/kg + EtOH, and APCV 200 mg/kg + EtOH. APCV 100 or 200 mg/kg, administered orally 1 h before the ethanol‐induced ulcer procedure delivery, increased the protective index % (26.82% and 31.40%, respectively). The histopathological results (using H&amp;E and PAS) indicated preserved gastric defense barriers (restored mucus secretion and gastric pH) and tissue architecture as a result of APCV pretreatment. APCV intervention (100 and 200 mg/kg) increased superoxide dismutase by 24.33% and 62.14%; catalase by 59.07% and 90.37%; and upregulated IL‐10 by 24.40% and 79.52%, while significantly (p &lt; 0.01) lowering MDA by 25.97% and 38.77%, as well as significantly (p &lt; 0.001) downregulated IL‐6 by 14.67% and 33.08% and TNF‐α by 37.82% and 47.59%, respectively, compared to ulcer controls. It could also be noted that inhibited apoptosis (inhibited pro‐apoptotic Bax and increased HSP 70 appearances in gastric tissues) occurred in gastric tissues pretreated with APCV. Taken together, APCV exhibited a gastroprotective potential against gastric ulcers, which is attributed to its attenuation effects on oxidative stress, inflammatory, and apoptotic pathways. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1155/jfbc/5544037
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        Text: English
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      – SubjectFull: Stomach ulcers
        Type: general
      – SubjectFull: Alcoholic intoxication
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      – SubjectFull: Tumor necrosis factors
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      – SubjectFull: Superoxide dismutase
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      – SubjectFull: Malondialdehyde
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      – SubjectFull: Centaurea
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      – SubjectFull: BAX protein
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      – SubjectFull: HSP70 heat-shock proteins
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              Text: 5/4/2026
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