View in EDS

Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva.

Saved in:
Bibliographic Details
Title: Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva.
Authors: Ding, Ling1 (AUTHOR), Zhang, Huizi1 (AUTHOR), Li, Yao1 (AUTHOR), Kameoka, Jun1 (AUTHOR) jkameoka@waseda.jp
Source: Lab on a Chip. 5/5/2026, Vol. 26 Issue 9, p2804-2819. 16p.
Subjects: Thread (Textiles), Electrochemical sensors, Saliva analysis, Microfluidics, Point-of-care testing, Microsensors, Cellulose fibers, Lactates
Abstract: The advancement of wearable and point-of-care (POC) biosensing technologies has driven a growing demand for microfluidic substrates that are flexible, hydrophilic, and compatible with electrochemical sensing. In this study, a lyocell-based thread microfluidic platform was developed to overcome limitations of conventional microfluidic systems. The device employs polypropylene (PP) mesh as a structural substrate and is coupled with a modal absorption pad to sustain consistent and continuous liquid transport. Lyocell's inherent capillary-driven wicking, superior hydrophilicity, semicrystalline microstructure, and high wet modulus collectively provide excellent liquid transport efficiency, structural stability under wet conditions, and bubble-free flow. Experimental analysis revealed that unmodified lyocell achieved liquid transport velocities comparable to plasma-treated cotton, confirming its intrinsic capillary efficiency. When integrated with a microneedle-based electrochemical sensor, the device demonstrated rapid analyte delivery and stable signal generation for both ferrocyanide and lactate detection. The thread-integrated lactate sensor exhibited a strong log-linear correlation, with limits of detection (LoD) of 0.433 mM using chronoamperometry (CA) and 0.51 mM using differential pulse voltammetry (DPV). Human saliva testing was also conducted using saliva samples, and the results were compared with blood lactate concentrations. A strong correlation was observed between salivary and blood lactate levels (R = 0.94). Overall, the lyocell–modal hybrid microfluidic platform provides a sustainable, low-cost, and scalable strategy for electrochemical point-of-care testing (POCT), offering a promising route toward next-generation lab-on-fabric systems. [ABSTRACT FROM AUTHOR]
Copyright of Lab on a Chip is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 193502729
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ding%2C+Ling%22">Ding, Ling</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Huizi%22">Zhang, Huizi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yao%22">Li, Yao</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kameoka%2C+Jun%22">Kameoka, Jun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> jkameoka@waseda.jp</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lab+on+a+Chip%22">Lab on a Chip</searchLink>. 5/5/2026, Vol. 26 Issue 9, p2804-2819. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Thread+%28Textiles%29%22">Thread (Textiles)</searchLink><br /><searchLink fieldCode="DE" term="%22Electrochemical+sensors%22">Electrochemical sensors</searchLink><br /><searchLink fieldCode="DE" term="%22Saliva+analysis%22">Saliva analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Microfluidics%22">Microfluidics</searchLink><br /><searchLink fieldCode="DE" term="%22Point-of-care+testing%22">Point-of-care testing</searchLink><br /><searchLink fieldCode="DE" term="%22Microsensors%22">Microsensors</searchLink><br /><searchLink fieldCode="DE" term="%22Cellulose+fibers%22">Cellulose fibers</searchLink><br /><searchLink fieldCode="DE" term="%22Lactates%22">Lactates</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The advancement of wearable and point-of-care (POC) biosensing technologies has driven a growing demand for microfluidic substrates that are flexible, hydrophilic, and compatible with electrochemical sensing. In this study, a lyocell-based thread microfluidic platform was developed to overcome limitations of conventional microfluidic systems. The device employs polypropylene (PP) mesh as a structural substrate and is coupled with a modal absorption pad to sustain consistent and continuous liquid transport. Lyocell's inherent capillary-driven wicking, superior hydrophilicity, semicrystalline microstructure, and high wet modulus collectively provide excellent liquid transport efficiency, structural stability under wet conditions, and bubble-free flow. Experimental analysis revealed that unmodified lyocell achieved liquid transport velocities comparable to plasma-treated cotton, confirming its intrinsic capillary efficiency. When integrated with a microneedle-based electrochemical sensor, the device demonstrated rapid analyte delivery and stable signal generation for both ferrocyanide and lactate detection. The thread-integrated lactate sensor exhibited a strong log-linear correlation, with limits of detection (LoD) of 0.433 mM using chronoamperometry (CA) and 0.51 mM using differential pulse voltammetry (DPV). Human saliva testing was also conducted using saliva samples, and the results were compared with blood lactate concentrations. A strong correlation was observed between salivary and blood lactate levels (R = 0.94). Overall, the lyocell–modal hybrid microfluidic platform provides a sustainable, low-cost, and scalable strategy for electrochemical point-of-care testing (POCT), offering a promising route toward next-generation lab-on-fabric systems. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lab on a Chip is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=193502729
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1039/d5lc01063b
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 2804
    Subjects:
      – SubjectFull: Thread (Textiles)
        Type: general
      – SubjectFull: Electrochemical sensors
        Type: general
      – SubjectFull: Saliva analysis
        Type: general
      – SubjectFull: Microfluidics
        Type: general
      – SubjectFull: Point-of-care testing
        Type: general
      – SubjectFull: Microsensors
        Type: general
      – SubjectFull: Cellulose fibers
        Type: general
      – SubjectFull: Lactates
        Type: general
    Titles:
      – TitleFull: Lyocell–modal thread microfluidic platform integrated with a microneedle sensor for lactate detection in saliva.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ding, Ling
      – PersonEntity:
          Name:
            NameFull: Zhang, Huizi
      – PersonEntity:
          Name:
            NameFull: Li, Yao
      – PersonEntity:
          Name:
            NameFull: Kameoka, Jun
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 05
              M: 05
              Text: 5/5/2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 14730197
          Numbering:
            – Type: volume
              Value: 26
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Lab on a Chip
              Type: main
ResultId 1