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A hollow mesoporous Prussian blue-cerium oxide-based oxygenating nanosystem for microenvironment remodeling in rheumatoid arthritis.

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Title: A hollow mesoporous Prussian blue-cerium oxide-based oxygenating nanosystem for microenvironment remodeling in rheumatoid arthritis.
Authors: Lin, Xiuke1 (AUTHOR), Liu, Yun1 (AUTHOR), Wu, Huiyi1 (AUTHOR), Guang, Wenyi1 (AUTHOR), Song, Hua1 (AUTHOR) songhua@xmu.edu.cn
Source: Chemical Engineering Journal. Jun2026, Vol. 537, pN.PAG-N.PAG. 1p.
Subjects: Rheumatoid arthritis, Nanomedicine, Cerium oxides, Reactive oxygen species, Physiological transport of oxygen, Cell physiology, Targeted drug delivery, Prussian blue
Abstract: Rheumatoid arthritis (RA) is a chronic and debilitating autoimmune disease, afflicts ∼1% of the global population. Despite therapeutic advances, conventional regimens remain first-line options, hampered by suboptimal targeting specificity and systemic toxicity that compromise clinical efficacy and safety. Reversing pathological RA lesion microenvironments, including acidic pH, hypoxia, reactive oxygen species (ROS) overload, and dysregulated pro-inflammatory cytokine expression, represents a pivotal strategy for durable RA treatment. Herein, we report a biomimetic oxygen-self-supplying nanosystem (HMPB-CaCe@SCM) engineered for multifaceted regulation of the pathological lesion microenvironment and effective RA therapy. This strategy employs hollow mesoporous Prussian blue (HMPB) as a multifunctional carrier, incorporating calcium peroxide (CaO₂) as an oxygen-generator and cerium dioxide (CeO₂) as an ROS-scavenging antioxidant, with an outer coating of adipose-derived mesenchymal stem cell membrane (ADSCM). The obtained HMPB-CaCe@SCM not only exhibited improved multivalent redox cycling efficiency of Fe2+-Fe3+/Ce3+-Ce4+, enabling efficient ROS scavenging coupled with oxygen generation to alleviate RA hypoxia, but also could neutralize the acidic microenvironment, restoring the physiological pH levels at RA sites. Additionally, ADSCM mediated intelligent targeting significantly promoted the accumulation of HMPB-CaCe@SCM at RA lesion sites, optimizing therapeutic efficacy while minimizing off-target effects. In vitro cellular studies and in vivo animal models of RA demonstrated that HMPB-CaCe@SCM possesses excellent biocompatibility and safety. Mechanistically, this nanosystem suppresses excessive ROS production, reduces the expression levels of key pro-inflammatory cytokines (e.g. , IL-1β/IL-6), and protects articular structures by re-establishing redox homeostasis and normalizing the lesion microenvironment. By overcoming monotherapy limitations, this strategy establishes a synergistic " Oxygen Self-supply, Microenvironment Remodeling, and Precision Delivery (OSRD)" paradigm, offering a highly effective, low-toxicity nanotherapeutic strategy with substantial translational potential for RA theranostics. • A multifunctional nanosystem achieves hypoxia relief, microenvironment remodeling, and targeted synergistic anti-RA therapy. • A dual nanocatalytic redox cycle efficiently scavenges ROS and continuously supplies oxygen to inflammatory lesions. • ADSCM coating confers active targeting toward RA lesions, improving therapeutic precision and reducing systemic toxicity. • This nanoplatform enables a self-reinforcing, target-specific anti-RA strategy with promising clinical translation potential. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: A hollow mesoporous Prussian blue-cerium oxide-based oxygenating nanosystem for microenvironment remodeling in rheumatoid arthritis.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Xiuke%22">Lin, Xiuke</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Yun%22">Liu, Yun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Huiyi%22">Wu, Huiyi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guang%2C+Wenyi%22">Guang, Wenyi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Hua%22">Song, Hua</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> songhua@xmu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Engineering+Journal%22">Chemical Engineering Journal</searchLink>. Jun2026, Vol. 537, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Rheumatoid+arthritis%22">Rheumatoid arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Cerium+oxides%22">Cerium oxides</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+oxygen+species%22">Reactive oxygen species</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+transport+of+oxygen%22">Physiological transport of oxygen</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+physiology%22">Cell physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Prussian+blue%22">Prussian blue</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Rheumatoid arthritis (RA) is a chronic and debilitating autoimmune disease, afflicts ∼1% of the global population. Despite therapeutic advances, conventional regimens remain first-line options, hampered by suboptimal targeting specificity and systemic toxicity that compromise clinical efficacy and safety. Reversing pathological RA lesion microenvironments, including acidic pH, hypoxia, reactive oxygen species (ROS) overload, and dysregulated pro-inflammatory cytokine expression, represents a pivotal strategy for durable RA treatment. Herein, we report a biomimetic oxygen-self-supplying nanosystem (HMPB-CaCe@SCM) engineered for multifaceted regulation of the pathological lesion microenvironment and effective RA therapy. This strategy employs hollow mesoporous Prussian blue (HMPB) as a multifunctional carrier, incorporating calcium peroxide (CaO₂) as an oxygen-generator and cerium dioxide (CeO₂) as an ROS-scavenging antioxidant, with an outer coating of adipose-derived mesenchymal stem cell membrane (ADSCM). The obtained HMPB-CaCe@SCM not only exhibited improved multivalent redox cycling efficiency of Fe2+-Fe3+/Ce3+-Ce4+, enabling efficient ROS scavenging coupled with oxygen generation to alleviate RA hypoxia, but also could neutralize the acidic microenvironment, restoring the physiological pH levels at RA sites. Additionally, ADSCM mediated intelligent targeting significantly promoted the accumulation of HMPB-CaCe@SCM at RA lesion sites, optimizing therapeutic efficacy while minimizing off-target effects. In vitro cellular studies and in vivo animal models of RA demonstrated that HMPB-CaCe@SCM possesses excellent biocompatibility and safety. Mechanistically, this nanosystem suppresses excessive ROS production, reduces the expression levels of key pro-inflammatory cytokines (e.g. , IL-1β/IL-6), and protects articular structures by re-establishing redox homeostasis and normalizing the lesion microenvironment. By overcoming monotherapy limitations, this strategy establishes a synergistic " Oxygen Self-supply, Microenvironment Remodeling, and Precision Delivery (OSRD)" paradigm, offering a highly effective, low-toxicity nanotherapeutic strategy with substantial translational potential for RA theranostics. • A multifunctional nanosystem achieves hypoxia relief, microenvironment remodeling, and targeted synergistic anti-RA therapy. • A dual nanocatalytic redox cycle efficiently scavenges ROS and continuously supplies oxygen to inflammatory lesions. • ADSCM coating confers active targeting toward RA lesions, improving therapeutic precision and reducing systemic toxicity. • This nanoplatform enables a self-reinforcing, target-specific anti-RA strategy with promising clinical translation potential. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.cej.2026.176053
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Rheumatoid arthritis
        Type: general
      – SubjectFull: Nanomedicine
        Type: general
      – SubjectFull: Cerium oxides
        Type: general
      – SubjectFull: Reactive oxygen species
        Type: general
      – SubjectFull: Physiological transport of oxygen
        Type: general
      – SubjectFull: Cell physiology
        Type: general
      – SubjectFull: Targeted drug delivery
        Type: general
      – SubjectFull: Prussian blue
        Type: general
    Titles:
      – TitleFull: A hollow mesoporous Prussian blue-cerium oxide-based oxygenating nanosystem for microenvironment remodeling in rheumatoid arthritis.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Lin, Xiuke
      – PersonEntity:
          Name:
            NameFull: Liu, Yun
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            NameFull: Wu, Huiyi
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            NameFull: Guang, Wenyi
      – PersonEntity:
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            NameFull: Song, Hua
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          Dates:
            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 13858947
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            – Type: volume
              Value: 537
          Titles:
            – TitleFull: Chemical Engineering Journal
              Type: main
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