A hollow mesoporous Prussian blue-cerium oxide-based oxygenating nanosystem for microenvironment remodeling in rheumatoid arthritis.
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| Title: | A hollow mesoporous Prussian blue-cerium oxide-based oxygenating nanosystem for microenvironment remodeling in rheumatoid arthritis. |
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| Authors: | Lin, Xiuke1 (AUTHOR), Liu, Yun1 (AUTHOR), Wu, Huiyi1 (AUTHOR), Guang, Wenyi1 (AUTHOR), Song, Hua1 (AUTHOR) songhua@xmu.edu.cn |
| Source: | Chemical Engineering Journal. Jun2026, Vol. 537, pN.PAG-N.PAG. 1p. |
| Subjects: | Rheumatoid arthritis, Nanomedicine, Cerium oxides, Reactive oxygen species, Physiological transport of oxygen, Cell physiology, Targeted drug delivery, Prussian blue |
| Abstract: | Rheumatoid arthritis (RA) is a chronic and debilitating autoimmune disease, afflicts ∼1% of the global population. Despite therapeutic advances, conventional regimens remain first-line options, hampered by suboptimal targeting specificity and systemic toxicity that compromise clinical efficacy and safety. Reversing pathological RA lesion microenvironments, including acidic pH, hypoxia, reactive oxygen species (ROS) overload, and dysregulated pro-inflammatory cytokine expression, represents a pivotal strategy for durable RA treatment. Herein, we report a biomimetic oxygen-self-supplying nanosystem (HMPB-CaCe@SCM) engineered for multifaceted regulation of the pathological lesion microenvironment and effective RA therapy. This strategy employs hollow mesoporous Prussian blue (HMPB) as a multifunctional carrier, incorporating calcium peroxide (CaO₂) as an oxygen-generator and cerium dioxide (CeO₂) as an ROS-scavenging antioxidant, with an outer coating of adipose-derived mesenchymal stem cell membrane (ADSCM). The obtained HMPB-CaCe@SCM not only exhibited improved multivalent redox cycling efficiency of Fe2+-Fe3+/Ce3+-Ce4+, enabling efficient ROS scavenging coupled with oxygen generation to alleviate RA hypoxia, but also could neutralize the acidic microenvironment, restoring the physiological pH levels at RA sites. Additionally, ADSCM mediated intelligent targeting significantly promoted the accumulation of HMPB-CaCe@SCM at RA lesion sites, optimizing therapeutic efficacy while minimizing off-target effects. In vitro cellular studies and in vivo animal models of RA demonstrated that HMPB-CaCe@SCM possesses excellent biocompatibility and safety. Mechanistically, this nanosystem suppresses excessive ROS production, reduces the expression levels of key pro-inflammatory cytokines (e.g. , IL-1β/IL-6), and protects articular structures by re-establishing redox homeostasis and normalizing the lesion microenvironment. By overcoming monotherapy limitations, this strategy establishes a synergistic " Oxygen Self-supply, Microenvironment Remodeling, and Precision Delivery (OSRD)" paradigm, offering a highly effective, low-toxicity nanotherapeutic strategy with substantial translational potential for RA theranostics. • A multifunctional nanosystem achieves hypoxia relief, microenvironment remodeling, and targeted synergistic anti-RA therapy. • A dual nanocatalytic redox cycle efficiently scavenges ROS and continuously supplies oxygen to inflammatory lesions. • ADSCM coating confers active targeting toward RA lesions, improving therapeutic precision and reducing systemic toxicity. • This nanoplatform enables a self-reinforcing, target-specific anti-RA strategy with promising clinical translation potential. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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