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oDual‐MRF: An Optimized Dual‐Alternating MR Fingerprinting Sequence.

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Bibliographic Details
Title:	oDual‐MRF: An Optimized Dual‐Alternating MR Fingerprinting Sequence.
Authors:	Li, Shizhuo¹ (AUTHOR), Zhao, Bo^2,3 (AUTHOR), Xu, Pengcheng¹ (AUTHOR), Chen, Yuting¹ (AUTHOR), Liu, Huafeng^1,4 (AUTHOR), Ye, Huihui⁵ (AUTHOR) yehuihui@hdu.edu.cn
Source:	Magnetic Resonance in Medicine. Jul2026, Vol. 96 Issue 1, p27-36. 10p.
Subjects:	Magnetic resonance imaging, Minimum variance estimation
Abstract:	Purpose: To improve the quantitative accuracy of T2$$ {T}_2 $$ mapping in magnetic resonance fingerprinting by introducing the Dual‐MRF sequence, which alternates between FISP and PSIF acquisitions, and optimizing its parameters using estimator variance minimization. Methods: The PSIF module was incorporated into the MRF sequence, resulting in the Dual‐MRF sequence with alternating signals. Furthermore, the oDual‐MRF sequence was obtained by optimizing parameters such as flip angle, repetition time, and alternation scheme using the Cramer‐Rao Bound. The performance of FISP‐MRF, Dual‐MRF, and oDual‐MRF was evaluated through simulations, phantom experiments, and in vivo studies. Results: Dual‐MRF achieved higher T2$$ {T}_2 $$ quantification accuracy compared to conventional FISP‐MRF while maintaining T1$$ {T}_1 $$ accuracy. oDual‐MRF further improved T2$$ {T}_2 $$ accuracy without compromising T1$$ {T}_1 $$ map quality. Conclusion: CRB‐based optimization of Dual‐MRF enhances T2$$ {T}_2 $$ quantification while preserving T1$$ {T}_1 $$ accuracy, providing a promising framework for reliable multiparametric MRF. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	Purpose: To improve the quantitative accuracy of T2$$ {T}_2 $$ mapping in magnetic resonance fingerprinting by introducing the Dual‐MRF sequence, which alternates between FISP and PSIF acquisitions, and optimizing its parameters using estimator variance minimization. Methods: The PSIF module was incorporated into the MRF sequence, resulting in the Dual‐MRF sequence with alternating signals. Furthermore, the oDual‐MRF sequence was obtained by optimizing parameters such as flip angle, repetition time, and alternation scheme using the Cramer‐Rao Bound. The performance of FISP‐MRF, Dual‐MRF, and oDual‐MRF was evaluated through simulations, phantom experiments, and in vivo studies. Results: Dual‐MRF achieved higher T2$$ {T}_2 $$ quantification accuracy compared to conventional FISP‐MRF while maintaining T1$$ {T}_1 $$ accuracy. oDual‐MRF further improved T2$$ {T}_2 $$ accuracy without compromising T1$$ {T}_1 $$ map quality. Conclusion: CRB‐based optimization of Dual‐MRF enhances T2$$ {T}_2 $$ quantification while preserving T1$$ {T}_1 $$ accuracy, providing a promising framework for reliable multiparametric MRF. [ABSTRACT FROM AUTHOR]
ISSN:	07403194
DOI:	10.1002/mrm.70345