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oDual‐MRF: An Optimized Dual‐Alternating MR Fingerprinting Sequence.

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Title: oDual‐MRF: An Optimized Dual‐Alternating MR Fingerprinting Sequence.
Authors: Li, Shizhuo1 (AUTHOR), Zhao, Bo2,3 (AUTHOR), Xu, Pengcheng1 (AUTHOR), Chen, Yuting1 (AUTHOR), Liu, Huafeng1,4 (AUTHOR), Ye, Huihui5 (AUTHOR) yehuihui@hdu.edu.cn
Source: Magnetic Resonance in Medicine. Jul2026, Vol. 96 Issue 1, p27-36. 10p.
Subjects: Magnetic resonance imaging, Minimum variance estimation
Abstract: Purpose: To improve the quantitative accuracy of T2$$ {T}_2 $$ mapping in magnetic resonance fingerprinting by introducing the Dual‐MRF sequence, which alternates between FISP and PSIF acquisitions, and optimizing its parameters using estimator variance minimization. Methods: The PSIF module was incorporated into the MRF sequence, resulting in the Dual‐MRF sequence with alternating signals. Furthermore, the oDual‐MRF sequence was obtained by optimizing parameters such as flip angle, repetition time, and alternation scheme using the Cramer‐Rao Bound. The performance of FISP‐MRF, Dual‐MRF, and oDual‐MRF was evaluated through simulations, phantom experiments, and in vivo studies. Results: Dual‐MRF achieved higher T2$$ {T}_2 $$ quantification accuracy compared to conventional FISP‐MRF while maintaining T1$$ {T}_1 $$ accuracy. oDual‐MRF further improved T2$$ {T}_2 $$ accuracy without compromising T1$$ {T}_1 $$ map quality. Conclusion: CRB‐based optimization of Dual‐MRF enhances T2$$ {T}_2 $$ quantification while preserving T1$$ {T}_1 $$ accuracy, providing a promising framework for reliable multiparametric MRF. [ABSTRACT FROM AUTHOR]
Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: oDual‐MRF: An Optimized Dual‐Alternating MR Fingerprinting Sequence.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Shizhuo%22">Li, Shizhuo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Bo%22">Zhao, Bo</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Pengcheng%22">Xu, Pengcheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Yuting%22">Chen, Yuting</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Huafeng%22">Liu, Huafeng</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Huihui%22">Ye, Huihui</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> yehuihui@hdu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jul2026, Vol. 96 Issue 1, p27-36. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Minimum+variance+estimation%22">Minimum variance estimation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To improve the quantitative accuracy of T2$$ {T}_2 $$ mapping in magnetic resonance fingerprinting by introducing the Dual‐MRF sequence, which alternates between FISP and PSIF acquisitions, and optimizing its parameters using estimator variance minimization. Methods: The PSIF module was incorporated into the MRF sequence, resulting in the Dual‐MRF sequence with alternating signals. Furthermore, the oDual‐MRF sequence was obtained by optimizing parameters such as flip angle, repetition time, and alternation scheme using the Cramer‐Rao Bound. The performance of FISP‐MRF, Dual‐MRF, and oDual‐MRF was evaluated through simulations, phantom experiments, and in vivo studies. Results: Dual‐MRF achieved higher T2$$ {T}_2 $$ quantification accuracy compared to conventional FISP‐MRF while maintaining T1$$ {T}_1 $$ accuracy. oDual‐MRF further improved T2$$ {T}_2 $$ accuracy without compromising T1$$ {T}_1 $$ map quality. Conclusion: CRB‐based optimization of Dual‐MRF enhances T2$$ {T}_2 $$ quantification while preserving T1$$ {T}_1 $$ accuracy, providing a promising framework for reliable multiparametric MRF. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/mrm.70345
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        Text: English
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              M: 07
              Text: Jul2026
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              Y: 2026
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