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Structural Optimization of Magnesium Alloy Rib Claw and Evaluation of Its Mechanical Reliability In Vitro and In Vivo.

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Title: Structural Optimization of Magnesium Alloy Rib Claw and Evaluation of Its Mechanical Reliability In Vitro and In Vivo.
Authors: Shen, Jie1 (AUTHOR), Wang, Ziming1,2 (AUTHOR), Huang, Hua2,3 (AUTHOR), Chu, Zhenhua1 (AUTHOR), Zhang, Jian2,3 (AUTHOR), Yin, Lin3 (AUTHOR)
Source: Materials (1996-1944). May2026, Vol. 19 Issue 9, p1833. 20p.
Subjects: Structural optimization, Magnesium alloys, In vivo studies, In vitro studies, Bioabsorbable implants, Finite element method, Artificial implants, Reliability in engineering
Abstract: Highlights: A "design-for-degradation" approach reduces stress concentration in Mg alloy rib claws. Optimized Gen3 Mg claws show superior yield load (358 ± 21 N) with minimal mechanical anisotropy vs. commercial Ti claws. A 24-week large animal model confirms controlled degradation with maintained mechanical integrity during bone healing. Finite element analysis (FEA) validates a 54.15% reduction in maximum von Mises stress via structural optimization. The structural optimization and mechanical reliability of novel biodegradable JDBM magnesium alloy rib claws were investigated in this study. Simulation analysis, in vitro bending tests, and a 24-week animal implantation experiment demonstrated the promising application potential of the optimized Gen3 magnesium alloy rib claw. Compared with the pre-optimized Gen1 design, finite element analysis (FEA) confirmed that the Gen3 claw—achieved by increasing the width from 6.0 mm to 8.52 mm and adding 1.65 mm transitional fillets at stress concentration zones—resulted in a 54.15% reduction in the maximum von Mises stress (from 116.91 MPa to 53.59 MPa) and a 54.4% decrease in the equivalent strain. In vitro four-point bending tests (ASTM F382-compliant, 11.7 mm span) showed that the Gen3 magnesium claws exhibited a significantly higher yield load (358 ± 21 N) compared with titanium claws (219 ± 16 N; p < 0.05, independent t-test). A 24-week in vivo evaluation in Bama pigs further confirmed the excellent mechanical reliability of the optimized Gen3 magnesium alloy rib claw, and no fractures were observed throughout the implantation period. [ABSTRACT FROM AUTHOR]
Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Structural Optimization of Magnesium Alloy Rib Claw and Evaluation of Its Mechanical Reliability In Vitro and In Vivo.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shen%2C+Jie%22&quot;&gt;Shen, Jie&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Ziming%22&quot;&gt;Wang, Ziming&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Huang%2C+Hua%22&quot;&gt;Huang, Hua&lt;/searchLink&gt;&lt;relatesTo&gt;2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chu%2C+Zhenhua%22&quot;&gt;Chu, Zhenhua&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Jian%22&quot;&gt;Zhang, Jian&lt;/searchLink&gt;&lt;relatesTo&gt;2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yin%2C+Lin%22&quot;&gt;Yin, Lin&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)
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  Data: Highlights: A &quot;design-for-degradation&quot; approach reduces stress concentration in Mg alloy rib claws. Optimized Gen3 Mg claws show superior yield load (358 &#177; 21 N) with minimal mechanical anisotropy vs. commercial Ti claws. A 24-week large animal model confirms controlled degradation with maintained mechanical integrity during bone healing. Finite element analysis (FEA) validates a 54.15% reduction in maximum von Mises stress via structural optimization. The structural optimization and mechanical reliability of novel biodegradable JDBM magnesium alloy rib claws were investigated in this study. Simulation analysis, in vitro bending tests, and a 24-week animal implantation experiment demonstrated the promising application potential of the optimized Gen3 magnesium alloy rib claw. Compared with the pre-optimized Gen1 design, finite element analysis (FEA) confirmed that the Gen3 claw—achieved by increasing the width from 6.0 mm to 8.52 mm and adding 1.65 mm transitional fillets at stress concentration zones—resulted in a 54.15% reduction in the maximum von Mises stress (from 116.91 MPa to 53.59 MPa) and a 54.4% decrease in the equivalent strain. In vitro four-point bending tests (ASTM F382-compliant, 11.7 mm span) showed that the Gen3 magnesium claws exhibited a significantly higher yield load (358 &#177; 21 N) compared with titanium claws (219 &#177; 16 N; p &lt; 0.05, independent t-test). A 24-week in vivo evaluation in Bama pigs further confirmed the excellent mechanical reliability of the optimized Gen3 magnesium alloy rib claw, and no fractures were observed throughout the implantation period. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Materials (1996-1944) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/ma19091833
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 20
        StartPage: 1833
    Subjects:
      – SubjectFull: Structural optimization
        Type: general
      – SubjectFull: Magnesium alloys
        Type: general
      – SubjectFull: In vivo studies
        Type: general
      – SubjectFull: In vitro studies
        Type: general
      – SubjectFull: Bioabsorbable implants
        Type: general
      – SubjectFull: Finite element method
        Type: general
      – SubjectFull: Artificial implants
        Type: general
      – SubjectFull: Reliability in engineering
        Type: general
    Titles:
      – TitleFull: Structural Optimization of Magnesium Alloy Rib Claw and Evaluation of Its Mechanical Reliability In Vitro and In Vivo.
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          Name:
            NameFull: Shen, Jie
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            NameFull: Wang, Ziming
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            NameFull: Huang, Hua
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            NameFull: Chu, Zhenhua
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            NameFull: Zhang, Jian
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              M: 05
              Text: May2026
              Type: published
              Y: 2026
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              Value: 19
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              Value: 9
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            – TitleFull: Materials (1996-1944)
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