A New Treatment Approach for Tympanic Membrane Repair: Stabilization of Fascia Grafts Using a PLGA-Based Tissue Stabilizer.
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| Title: | A New Treatment Approach for Tympanic Membrane Repair: Stabilization of Fascia Grafts Using a PLGA-Based Tissue Stabilizer. |
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| Authors: | Kaga, Sadik1 (AUTHOR), Capanoglu, Fatih2 (AUTHOR), Kaga, Elif3 (AUTHOR) elif.kaga@afsu.edu.tr |
| Source: | Polymers (20734360). May2026, Vol. 18 Issue 9, p1025. 17p. |
| Subjects: | Tympanoplasty, Biodegradable materials, Fasciae (Anatomy), Medical polymers, Tympanic membrane perforation, Tissue engineering, Operative surgery |
| Abstract: | This study aimed to design a bioabsorbable, biocompatible poly(lactic-co-glycolic acid) (PLGA)-based tissue stabilizer for a new tympanoplasty method and to evaluate its feasibility. A PLGA copolymer with a lactic acid: glycolic acid ratio of 50:50 was used to fabricate the stabilizers via melt molding using custom-designed molds. The surface morphology of the fabricated stabilizers was analyzed by scanning electron microscopy (SEM). In vitro degradation profiles were evaluated over a 60-day period in phosphate buffered saline (PBS), simulated body fluid (SBF), and trypsin environments, and biocompatibility was assessed using direct and indirect proliferation assays with human fibroblasts. SEM analyses revealed a smooth and homogeneous surface morphology. Degradation studies demonstrated a controlled and progressive decrease in residual mass over time. Cell proliferation assays indicated that the PLGA stabilizer exhibited no cytotoxic effects. In rabbit models, the tissue stabilizer improved fascia graft stabilization, resulting in more regular epithelialization and higher tympanic membrane closure rates compared with the control and fat myringoplasty groups. This approach may improve surgical efficiency and patient comfort by enabling shorter operative times, reduced surgical invasiveness, and the potential use of local anesthesia. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 193716160 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A New Treatment Approach for Tympanic Membrane Repair: Stabilization of Fascia Grafts Using a PLGA-Based Tissue Stabilizer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kaga%2C+Sadik%22">Kaga, Sadik</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Capanoglu%2C+Fatih%22">Capanoglu, Fatih</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaga%2C+Elif%22">Kaga, Elif</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> elif.kaga@afsu.edu.tr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. May2026, Vol. 18 Issue 9, p1025. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tympanoplasty%22">Tympanoplasty</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradable+materials%22">Biodegradable materials</searchLink><br /><searchLink fieldCode="DE" term="%22Fasciae+%28Anatomy%29%22">Fasciae (Anatomy)</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+polymers%22">Medical polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Tympanic+membrane+perforation%22">Tympanic membrane perforation</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Operative+surgery%22">Operative surgery</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This study aimed to design a bioabsorbable, biocompatible poly(lactic-co-glycolic acid) (PLGA)-based tissue stabilizer for a new tympanoplasty method and to evaluate its feasibility. A PLGA copolymer with a lactic acid: glycolic acid ratio of 50:50 was used to fabricate the stabilizers via melt molding using custom-designed molds. The surface morphology of the fabricated stabilizers was analyzed by scanning electron microscopy (SEM). In vitro degradation profiles were evaluated over a 60-day period in phosphate buffered saline (PBS), simulated body fluid (SBF), and trypsin environments, and biocompatibility was assessed using direct and indirect proliferation assays with human fibroblasts. SEM analyses revealed a smooth and homogeneous surface morphology. Degradation studies demonstrated a controlled and progressive decrease in residual mass over time. Cell proliferation assays indicated that the PLGA stabilizer exhibited no cytotoxic effects. In rabbit models, the tissue stabilizer improved fascia graft stabilization, resulting in more regular epithelialization and higher tympanic membrane closure rates compared with the control and fat myringoplasty groups. This approach may improve surgical efficiency and patient comfort by enabling shorter operative times, reduced surgical invasiveness, and the potential use of local anesthesia. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym18091025 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1025 Subjects: – SubjectFull: Tympanoplasty Type: general – SubjectFull: Biodegradable materials Type: general – SubjectFull: Fasciae (Anatomy) Type: general – SubjectFull: Medical polymers Type: general – SubjectFull: Tympanic membrane perforation Type: general – SubjectFull: Tissue engineering Type: general – SubjectFull: Operative surgery Type: general Titles: – TitleFull: A New Treatment Approach for Tympanic Membrane Repair: Stabilization of Fascia Grafts Using a PLGA-Based Tissue Stabilizer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kaga, Sadik – PersonEntity: Name: NameFull: Capanoglu, Fatih – PersonEntity: Name: NameFull: Kaga, Elif IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 18 – Type: issue Value: 9 Titles: – TitleFull: Polymers (20734360) Type: main |
| ResultId | 1 |
