TiO 2 Nanocomposite GelMA Film as Wound Dressing: Physicochemical, Structural, Mechanical Properties and Antibacterial Activity Against Staphylococcus aureus.
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| Title: | TiO 2 Nanocomposite GelMA Film as Wound Dressing: Physicochemical, Structural, Mechanical Properties and Antibacterial Activity Against Staphylococcus aureus. |
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| Authors: | De Berardis, Barbara1 (AUTHOR) raffaella.pecci@iss.it, Pecci, Raffaella1,2 (AUTHOR), Morlino, Roberta2,3 (AUTHOR), Ioppolo, Pietro1 (AUTHOR), Ranaldi, Marco2,3 (AUTHOR), Iucci, Giovanna3 (AUTHOR), Ferrarini, Alessandro3 (AUTHOR), D'Avenio, Giuseppe1 (AUTHOR), De Angelis, Giorgio1 (AUTHOR), Ammendolia, Maria Grazia1 (AUTHOR) maria.ammendolia@iss.it |
| Source: | Nanomaterials (2079-4991). May2026, Vol. 16 Issue 9, p536. 24p. |
| Subjects: | Titanium dioxide, Surgical dressings, Controlled release drugs, Antibacterial agents, Mechanical behavior of materials, Chemical properties, Staphylococcus aureus |
| Abstract: | Bacterial infections can delay wound healing and represent serious medical problems both in the hospital and community settings, especially skin wound infections caused by Staphylococcus aureus. In this work, a gelatin hydrogel modified with photo-cross-linkable methacrylamide groups at 10% concentration (GelMA10%), enriched with titanium dioxide nanoparticles (TiO2NPs), and loaded with Neomycin sulphate was developed with the aim to realize a tissue for wound care with improved mechanical and antimicrobial properties. TiO2 nanocomposite GelMA films with two concentrations of TiO2NPs were characterized to assess physicochemical, structural and mechanical properties by scanning electron microscopy equipped with an energy-dispersive X-ray spectrometer (SEM/EDX), micro-computed tomography (micro-CT) and X-ray photoelectron spectroscopy (XPS). TiO2 nanocomposite GelMA films showed a more compact structure, reduced pore sizes and a higher compressive modulus at the increasing concentration of TiO2NPs. They were able to absorb and retain water for a prolonged time; however, no significant differences in the swelling degree at the increasing concentration of TiO2NPs were observed. In vitro drug release and antibacterial activity against Staphylococcus aureus of TiO2 nanocomposite GelMA film enriched with higher concentrations of TiO2NPs, identified as a suitable candidate for wound healing, were investigated. Both GelMA10% and TiO2 nanocomposite GelMA films loaded with drug exhibited a strong antibacterial action, whereas GelMA10% containing only TiO2NPs did not show any antimicrobial properties. [ABSTRACT FROM AUTHOR] |
| Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 193717469 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: TiO 2 Nanocomposite GelMA Film as Wound Dressing: Physicochemical, Structural, Mechanical Properties and Antibacterial Activity Against Staphylococcus aureus. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22De+Berardis%2C+Barbara%22">De Berardis, Barbara</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> raffaella.pecci@iss.it</i><br /><searchLink fieldCode="AR" term="%22Pecci%2C+Raffaella%22">Pecci, Raffaella</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morlino%2C+Roberta%22">Morlino, Roberta</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ioppolo%2C+Pietro%22">Ioppolo, Pietro</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ranaldi%2C+Marco%22">Ranaldi, Marco</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iucci%2C+Giovanna%22">Iucci, Giovanna</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferrarini%2C+Alessandro%22">Ferrarini, Alessandro</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Avenio%2C+Giuseppe%22">D'Avenio, Giuseppe</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Angelis%2C+Giorgio%22">De Angelis, Giorgio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ammendolia%2C+Maria+Grazia%22">Ammendolia, Maria Grazia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> maria.ammendolia@iss.it</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. May2026, Vol. 16 Issue 9, p536. 24p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Titanium+dioxide%22">Titanium dioxide</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+dressings%22">Surgical dressings</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+properties%22">Chemical properties</searchLink><br /><searchLink fieldCode="DE" term="%22Staphylococcus+aureus%22">Staphylococcus aureus</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Bacterial infections can delay wound healing and represent serious medical problems both in the hospital and community settings, especially skin wound infections caused by Staphylococcus aureus. In this work, a gelatin hydrogel modified with photo-cross-linkable methacrylamide groups at 10% concentration (GelMA10%), enriched with titanium dioxide nanoparticles (TiO2NPs), and loaded with Neomycin sulphate was developed with the aim to realize a tissue for wound care with improved mechanical and antimicrobial properties. TiO2 nanocomposite GelMA films with two concentrations of TiO2NPs were characterized to assess physicochemical, structural and mechanical properties by scanning electron microscopy equipped with an energy-dispersive X-ray spectrometer (SEM/EDX), micro-computed tomography (micro-CT) and X-ray photoelectron spectroscopy (XPS). TiO2 nanocomposite GelMA films showed a more compact structure, reduced pore sizes and a higher compressive modulus at the increasing concentration of TiO2NPs. They were able to absorb and retain water for a prolonged time; however, no significant differences in the swelling degree at the increasing concentration of TiO2NPs were observed. In vitro drug release and antibacterial activity against Staphylococcus aureus of TiO2 nanocomposite GelMA film enriched with higher concentrations of TiO2NPs, identified as a suitable candidate for wound healing, were investigated. Both GelMA10% and TiO2 nanocomposite GelMA films loaded with drug exhibited a strong antibacterial action, whereas GelMA10% containing only TiO2NPs did not show any antimicrobial properties. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/nano16090536 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 24 StartPage: 536 Subjects: – SubjectFull: Titanium dioxide Type: general – SubjectFull: Surgical dressings Type: general – SubjectFull: Controlled release drugs Type: general – SubjectFull: Antibacterial agents Type: general – SubjectFull: Mechanical behavior of materials Type: general – SubjectFull: Chemical properties Type: general – SubjectFull: Staphylococcus aureus Type: general Titles: – TitleFull: TiO 2 Nanocomposite GelMA Film as Wound Dressing: Physicochemical, Structural, Mechanical Properties and Antibacterial Activity Against Staphylococcus aureus. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: De Berardis, Barbara – PersonEntity: Name: NameFull: Pecci, Raffaella – PersonEntity: Name: NameFull: Morlino, Roberta – PersonEntity: Name: NameFull: Ioppolo, Pietro – PersonEntity: Name: NameFull: Ranaldi, Marco – PersonEntity: Name: NameFull: Iucci, Giovanna – PersonEntity: Name: NameFull: Ferrarini, Alessandro – PersonEntity: Name: NameFull: D'Avenio, Giuseppe – PersonEntity: Name: NameFull: De Angelis, Giorgio – PersonEntity: Name: NameFull: Ammendolia, Maria Grazia IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20794991 Numbering: – Type: volume Value: 16 – Type: issue Value: 9 Titles: – TitleFull: Nanomaterials (2079-4991) Type: main |
| ResultId | 1 |
