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Alkaloid Content, Anti‐Inflammatory Activity and Phytochemical Profile of White Velvet Bean (Mucuna pruriens L.) Seeds.

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Title: Alkaloid Content, Anti‐Inflammatory Activity and Phytochemical Profile of White Velvet Bean (Mucuna pruriens L.) Seeds.
Authors: Ha, Pham Thi Thu1 (AUTHOR) phamthithuha2@tdtu.edu.vn, Loi, Tran Thuy1 (AUTHOR), Thanh, Doan Thien1 (AUTHOR), Tuyen, Phung Thi2 (AUTHOR), Minh, Truong Ngoc3 (AUTHOR), Liem, Nguyen Thanh4 (AUTHOR), Hebishy, Essam (AUTHOR) ehebishy@wiley.com
Source: Journal of Food Processing & Preservation. 5/14/2026, Vol. 2026, p1-12. 12p.
Subjects: Alkaloids, Anti-inflammatory agents, Bioactive compounds, Chemical composition of plants, Gas chromatography/Mass spectrometry (GC-MS), Methanol
Abstract: Velvet bean (Mucuna pruriens L.), a leguminous plant widely recognised in traditional medicine, has garnered increasing scientific interest due to its diverse pharmacological potential, particularly in relation to its alkaloid‐rich seed composition. This study aimed to investigate the total alkaloid content, phytochemical composition and anti‐inflammatory activity of the methanol extract of M. pruriens seeds and its solvent‐partitioned fractions (n‐hexane, ethyl acetate, n‐butanol and aqueous). Quantitative analysis revealed that the aqueous and n‐hexane fractions contained notably higher alkaloid levels compared to the other extracts. Gas chromatography–mass spectrometry (GC–MS) analysis identified 36 bioactive compounds spanning multiple chemical classes such as alkanes, esters, acids, silanes and amides. Predominant compounds in the methanol extract included 9,12‐octadecadienoic acid (Z,Z)‐methyl ester (44.87%), hexadecanoic acid methyl ester (27.33%) and cis‐13‐octadecenoic acid methyl ester (10.16%). Notably, the ethyl acetate and aqueous fractions demonstrated potent anti‐inflammatory effects, with IC50 values of 69.32 and 83.06 μg/mL, respectively. The presence of decarine, an isoquinoline alkaloid with known anticancer and anti‐inflammatory properties, further underscores the pharmacological value of this species. These findings highlight the therapeutic promise of white velvet bean seeds and provide a biochemical foundation for future pharmaceutical applications. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Processing & Preservation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Alkaloid Content, Anti‐Inflammatory Activity and Phytochemical Profile of White Velvet Bean (Mucuna pruriens L.) Seeds.
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  Data: <searchLink fieldCode="AR" term="%22Ha%2C+Pham+Thi+Thu%22">Ha, Pham Thi Thu</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> phamthithuha2@tdtu.edu.vn</i><br /><searchLink fieldCode="AR" term="%22Loi%2C+Tran+Thuy%22">Loi, Tran Thuy</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thanh%2C+Doan+Thien%22">Thanh, Doan Thien</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tuyen%2C+Phung+Thi%22">Tuyen, Phung Thi</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Minh%2C+Truong+Ngoc%22">Minh, Truong Ngoc</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liem%2C+Nguyen+Thanh%22">Liem, Nguyen Thanh</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hebishy%2C+Essam%22">Hebishy, Essam</searchLink> (AUTHOR)<i> ehebishy@wiley.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Processing+%26+Preservation%22">Journal of Food Processing & Preservation</searchLink>. 5/14/2026, Vol. 2026, p1-12. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Alkaloids%22">Alkaloids</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Bioactive+compounds%22">Bioactive compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+composition+of+plants%22">Chemical composition of plants</searchLink><br /><searchLink fieldCode="DE" term="%22Gas+chromatography%2FMass+spectrometry+%28GC-MS%29%22">Gas chromatography/Mass spectrometry (GC-MS)</searchLink><br /><searchLink fieldCode="DE" term="%22Methanol%22">Methanol</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Velvet bean (Mucuna pruriens L.), a leguminous plant widely recognised in traditional medicine, has garnered increasing scientific interest due to its diverse pharmacological potential, particularly in relation to its alkaloid‐rich seed composition. This study aimed to investigate the total alkaloid content, phytochemical composition and anti‐inflammatory activity of the methanol extract of M. pruriens seeds and its solvent‐partitioned fractions (n‐hexane, ethyl acetate, n‐butanol and aqueous). Quantitative analysis revealed that the aqueous and n‐hexane fractions contained notably higher alkaloid levels compared to the other extracts. Gas chromatography–mass spectrometry (GC–MS) analysis identified 36 bioactive compounds spanning multiple chemical classes such as alkanes, esters, acids, silanes and amides. Predominant compounds in the methanol extract included 9,12‐octadecadienoic acid (Z,Z)‐methyl ester (44.87%), hexadecanoic acid methyl ester (27.33%) and cis‐13‐octadecenoic acid methyl ester (10.16%). Notably, the ethyl acetate and aqueous fractions demonstrated potent anti‐inflammatory effects, with IC50 values of 69.32 and 83.06 μg/mL, respectively. The presence of decarine, an isoquinoline alkaloid with known anticancer and anti‐inflammatory properties, further underscores the pharmacological value of this species. These findings highlight the therapeutic promise of white velvet bean seeds and provide a biochemical foundation for future pharmaceutical applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Processing & Preservation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/jfpp/1223757
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        Text: English
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        PageCount: 12
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      – SubjectFull: Alkaloids
        Type: general
      – SubjectFull: Anti-inflammatory agents
        Type: general
      – SubjectFull: Bioactive compounds
        Type: general
      – SubjectFull: Chemical composition of plants
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      – SubjectFull: Gas chromatography/Mass spectrometry (GC-MS)
        Type: general
      – SubjectFull: Methanol
        Type: general
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      – TitleFull: Alkaloid Content, Anti‐Inflammatory Activity and Phytochemical Profile of White Velvet Bean (Mucuna pruriens L.) Seeds.
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              M: 05
              Text: 5/14/2026
              Type: published
              Y: 2026
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