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Dual-template molecularly imprinted polymers based on dopamine-modified porous cellulose for simultaneous enrichment of oleanolic acid and ursolic acid from lingonberries.

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Title: Dual-template molecularly imprinted polymers based on dopamine-modified porous cellulose for simultaneous enrichment of oleanolic acid and ursolic acid from lingonberries.
Authors: Sun, Linan1,2,3 (AUTHOR), Zhang, Maoyu1,2,3 (AUTHOR), Qu, Ming1,2,3 (AUTHOR), Nie, Chengdong1,2,3 (AUTHOR), Wang, Tao1,2,3 (AUTHOR), Zhao, Jingru1,2,3 (AUTHOR), Zhou, Zhen1,2,3 (AUTHOR), Fu, Yujie1,4 (AUTHOR) yujie_fu@163.com
Source: Reactive & Functional Polymers. Jul2026, Vol. 224, pN.PAG-N.PAG. 1p.
Subjects: Imprinted polymers, Ursolic acid, Cellulose, Physisorption, Berries, Plant metabolites
Abstract: Ursolic acid (UA) and oleanolic acid (OA) are among the most commonly utilized natural products for liver protection and anti-hepatitis applications, and are also prevalent ingredients in skincare formulations. In this study, cellulose-based molecularly imprinted polymers (MCC/PDA-OA/UA-MIPs) were synthesized using surface molecular imprinting technology, wherein OA and UA bimodal template molecules were incorporated onto the surface of polydopamine-modified cellulose microspheres. The MCC/PDA-OA/UA-MIPs exhibited specific recognition ability towards OA and UA via the complementary imprinted cavities, thereby achieving simultaneous enrichment of both compounds. Characterization and adsorption evaluations revealed that the MCC/PDA-OA/UA-MIPs possessed a uniform shape, good stability, and selective adsorption properties; the maximum adsorption capacities for UA and OA reached 48.26 ± 1.97 mg g−1 and 38.06 ± 1.55 mg g−1, respectively. The enrichment efficiencies of OA and UA from lingonberry crude extract reached 62.12% and 68.46%. Overall, the MCC/PDA-OA/UA-MIPs developed in this work feature high enrichment efficiency and enhanced sustainability, providing a feasible alternative strategy for the targeted extraction of natural products. Scheme 1. The schematic synthesis process of MCC/PDA-OA/UA-MIPs. [Display omitted] • A green molecularly imprinted adsorbent material based on modified cellulose was developed. • Imprinted materials with porous structures have a greater specific surface area for adsorption. • Adsorption modeling of imprinted materials was developed. • Imprinted material successfully enriched ursolic acid and oleanolic acid from plants. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Ursolic acid (UA) and oleanolic acid (OA) are among the most commonly utilized natural products for liver protection and anti-hepatitis applications, and are also prevalent ingredients in skincare formulations. In this study, cellulose-based molecularly imprinted polymers (MCC/PDA-OA/UA-MIPs) were synthesized using surface molecular imprinting technology, wherein OA and UA bimodal template molecules were incorporated onto the surface of polydopamine-modified cellulose microspheres. The MCC/PDA-OA/UA-MIPs exhibited specific recognition ability towards OA and UA via the complementary imprinted cavities, thereby achieving simultaneous enrichment of both compounds. Characterization and adsorption evaluations revealed that the MCC/PDA-OA/UA-MIPs possessed a uniform shape, good stability, and selective adsorption properties; the maximum adsorption capacities for UA and OA reached 48.26 ± 1.97 mg g−1 and 38.06 ± 1.55 mg g−1, respectively. The enrichment efficiencies of OA and UA from lingonberry crude extract reached 62.12% and 68.46%. Overall, the MCC/PDA-OA/UA-MIPs developed in this work feature high enrichment efficiency and enhanced sustainability, providing a feasible alternative strategy for the targeted extraction of natural products. Scheme 1. The schematic synthesis process of MCC/PDA-OA/UA-MIPs. [Display omitted] • A green molecularly imprinted adsorbent material based on modified cellulose was developed. • Imprinted materials with porous structures have a greater specific surface area for adsorption. • Adsorption modeling of imprinted materials was developed. • Imprinted material successfully enriched ursolic acid and oleanolic acid from plants. [ABSTRACT FROM AUTHOR]
ISSN:13815148
DOI:10.1016/j.reactfunctpolym.2026.106738