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Green Coffee Bean Extract Mitigates Alzheimer's Disease in Male Rats.

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Title: Green Coffee Bean Extract Mitigates Alzheimer's Disease in Male Rats.
Authors: Abu-Almakarem, Amal S.1 (AUTHOR), R. Alzahrani, Othman2 (AUTHOR), Abu-Khudir, Rasha3,4 (AUTHOR), Alassar, S. R.5 (AUTHOR), El-Said, Karim Samy4 (AUTHOR) kareem.ali@science.tanta.edu.eg, Alkhodair, Sahar Abdulrahman6 (AUTHOR), Banjabi, Abeer A.6 (AUTHOR), Al-Bazi, Maha M.6,7 (AUTHOR), Mobasher, Maysa A.8 (AUTHOR), Soliman, Mohamed Mostafa9,10 (AUTHOR), Bose, Anupama (AUTHOR) abose@wiley.com
Source: Journal of Food Biochemistry. 5/19/2026, Vol. 2026, p1-19. 19p.
Subjects: Alzheimer's disease, Neuroprotective agents, Neurodegeneration, Oxidative stress, Plant extracts, Inflammation, Cognitive ability, PI3K/AKT pathway
Abstract: Green coffee bean extract (GCBE) has shown potential for antioxidants and anti‐inflammation due to its rich composition of bioactive compounds and polyphenols that possess neuroprotective properties, which have been suggested to counteract neurodegenerative processes associated with Alzheimer's disease (AD). This study investigated the effect of GCBE treatment on aluminum chloride (AlCl3)‐induced AD in male rats. The pharmacokinetic properties of GCBE bioactive compounds were analyzed using the ADMET Lab 2.0 web servers, and molecular docking studies were performed using AutoDock Vina. Forty male Sprague–Dawley rats were divided into four equal groups; Group I was the negative control group; Group II received 250 mg/kg of GCBE (1/10 of LD50) from the 25th day to the 36th day; Group III was given AlCl3 (175 mg/kg) orally for 25 days, and Group IV was administered AlCl3 for 25 days, like in Group III, and then treated with GCBE as in Group II. The results indicated that GCBE demonstrated promising phytochemical constituents with safe pharmacokinetic profiles. The LD50 of GCBE was 2500 mg/kg b. wt. Behavioral assessments revealed significant improvement in cognitive performance in GCBE‐treated rats compared with the untreated AD group. Biochemical analyses demonstrated that GCBE significantly reduced oxidative stress and inflammatory markers. Moreover, GCBE markedly upregulated the expression of protein kinase (Akt1), cAMP‐response element binding protein (CREB), and brain‐derived neurotrophic factor (BDNF) indicating activation of neuroprotective signaling pathways. Histopathological examination further confirmed the protective effects of GCBE on hippocampal neuronal integrity. These findings suggest that GCBE exerted significant neuroprotective effects against AD, potentially through upregulation of the Akt/CREB/BDNF pathway, highlighting its potential as a promising therapeutic strategy for neurodegenerative disorders. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 193890401
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PubTypeId: academicJournal
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  Data: Green Coffee Bean Extract Mitigates Alzheimer's Disease in Male Rats.
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  Data: <searchLink fieldCode="AR" term="%22Abu-Almakarem%2C+Amal+S%2E%22">Abu-Almakarem, Amal S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22R%2E+Alzahrani%2C+Othman%22">R. Alzahrani, Othman</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abu-Khudir%2C+Rasha%22">Abu-Khudir, Rasha</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alassar%2C+S%2E+R%2E%22">Alassar, S. R.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22El-Said%2C+Karim+Samy%22">El-Said, Karim Samy</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> kareem.ali@science.tanta.edu.eg</i><br /><searchLink fieldCode="AR" term="%22Alkhodair%2C+Sahar+Abdulrahman%22">Alkhodair, Sahar Abdulrahman</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Banjabi%2C+Abeer+A%2E%22">Banjabi, Abeer A.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Al-Bazi%2C+Maha+M%2E%22">Al-Bazi, Maha M.</searchLink><relatesTo>6,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mobasher%2C+Maysa+A%2E%22">Mobasher, Maysa A.</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soliman%2C+Mohamed+Mostafa%22">Soliman, Mohamed Mostafa</searchLink><relatesTo>9,10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bose%2C+Anupama%22">Bose, Anupama</searchLink> (AUTHOR)<i> abose@wiley.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. 5/19/2026, Vol. 2026, p1-19. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroprotective+agents%22">Neuroprotective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+extracts%22">Plant extracts</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22PI3K%2FAKT+pathway%22">PI3K/AKT pathway</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Green coffee bean extract (GCBE) has shown potential for antioxidants and anti‐inflammation due to its rich composition of bioactive compounds and polyphenols that possess neuroprotective properties, which have been suggested to counteract neurodegenerative processes associated with Alzheimer's disease (AD). This study investigated the effect of GCBE treatment on aluminum chloride (AlCl3)‐induced AD in male rats. The pharmacokinetic properties of GCBE bioactive compounds were analyzed using the ADMET Lab 2.0 web servers, and molecular docking studies were performed using AutoDock Vina. Forty male Sprague–Dawley rats were divided into four equal groups; Group I was the negative control group; Group II received 250 mg/kg of GCBE (1/10 of LD50) from the 25th day to the 36th day; Group III was given AlCl3 (175 mg/kg) orally for 25 days, and Group IV was administered AlCl3 for 25 days, like in Group III, and then treated with GCBE as in Group II. The results indicated that GCBE demonstrated promising phytochemical constituents with safe pharmacokinetic profiles. The LD50 of GCBE was 2500 mg/kg b. wt. Behavioral assessments revealed significant improvement in cognitive performance in GCBE‐treated rats compared with the untreated AD group. Biochemical analyses demonstrated that GCBE significantly reduced oxidative stress and inflammatory markers. Moreover, GCBE markedly upregulated the expression of protein kinase (Akt1), cAMP‐response element binding protein (CREB), and brain‐derived neurotrophic factor (BDNF) indicating activation of neuroprotective signaling pathways. Histopathological examination further confirmed the protective effects of GCBE on hippocampal neuronal integrity. These findings suggest that GCBE exerted significant neuroprotective effects against AD, potentially through upregulation of the Akt/CREB/BDNF pathway, highlighting its potential as a promising therapeutic strategy for neurodegenerative disorders. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/jfbc/5511502
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        Text: English
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        PageCount: 19
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      – SubjectFull: Alzheimer's disease
        Type: general
      – SubjectFull: Neuroprotective agents
        Type: general
      – SubjectFull: Neurodegeneration
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      – SubjectFull: Oxidative stress
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      – SubjectFull: Plant extracts
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      – SubjectFull: Inflammation
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      – SubjectFull: PI3K/AKT pathway
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              Text: 5/19/2026
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