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Development of 3D printed biodegradable polymer-based drug delivery implants for post cataract surgery treatment.

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Title: Development of 3D printed biodegradable polymer-based drug delivery implants for post cataract surgery treatment.
Authors: Subhash, Nayana E.1 (AUTHOR), Nair, Soumya2 (AUTHOR), Srinivas, Srilatha Parampalli3 (AUTHOR), Bhandary, Sulatha V.2 (AUTHOR) sulatha.bhandary@manipal.edu, Guru, Bharath Raja1 (AUTHOR) bharath.guru@manipal.edu
Source: Journal of Biomaterials Science -- Polymer Edition. Jun2026, Vol. 37 Issue 8, p1441-1463. 23p.
Subjects: Three-dimensional printing, Bioabsorbable implants, Ophthalmology, Cataract surgery, Biodegradable plastics, Postoperative care, Controlled release drugs
Abstract: Cataracts affect millions of people worldwide; surgery and intensive post-operative care are the current standard of treatment. However, ocular barriers to drug delivery often impede recovery after surgery. This study proposes a potential solution to enhance post-cataract care by developing a biodegradable, controlled-release implant using 3D printing technology and follows the guidelines given by the All-India Ophthalmological Society (AIOS). The implant was designed to be placed into the capsular bag of the eye during the surgery and employs Poly(lactic-co-glycolic acid) (PLGA) as a drug carrier, delivering a combination of drugs such as Dexamethasone (DEX), Moxifloxacin (MOX), and Nepafenac (NEPA) directly into the eye. Two sets of drugs loaded implants were prepared, namely DEX-MOX-PLGA and NEPA-PLGA to mimic the conventional administration of corresponding eye drops used in post-operative management. A two-step process involving hot-melt extrusion and 3D printing, was utilised to prepare these implants. The prepared implants were characterised and the in vitro results aligned with the clinically prescribed regimens. The prepared implants were able to overcome the challenges like consistency of size and the in vitro release profile which were encountered in the previously published hot-melt extrusion only study. This approach demonstrates the feasibility of combining cataract surgery with post-operative drug delivery in a single procedure. The implants provided sustained drug release profiles consistent with clinical dosing regimens and were well substantiated in in vivo rabbit model, supporting their potential to improve patient compliance and recovery in future therapeutic applications. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 194088673
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Development of 3D printed biodegradable polymer-based drug delivery implants for post cataract surgery treatment.
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  Data: <searchLink fieldCode="AR" term="%22Subhash%2C+Nayana+E%2E%22">Subhash, Nayana E.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nair%2C+Soumya%22">Nair, Soumya</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Srinivas%2C+Srilatha+Parampalli%22">Srinivas, Srilatha Parampalli</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhandary%2C+Sulatha+V%2E%22">Bhandary, Sulatha V.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> sulatha.bhandary@manipal.edu</i><br /><searchLink fieldCode="AR" term="%22Guru%2C+Bharath+Raja%22">Guru, Bharath Raja</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> bharath.guru@manipal.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomaterials+Science+--+Polymer+Edition%22">Journal of Biomaterials Science -- Polymer Edition</searchLink>. Jun2026, Vol. 37 Issue 8, p1441-1463. 23p.
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  Data: <searchLink fieldCode="DE" term="%22Three-dimensional+printing%22">Three-dimensional printing</searchLink><br /><searchLink fieldCode="DE" term="%22Bioabsorbable+implants%22">Bioabsorbable implants</searchLink><br /><searchLink fieldCode="DE" term="%22Ophthalmology%22">Ophthalmology</searchLink><br /><searchLink fieldCode="DE" term="%22Cataract+surgery%22">Cataract surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradable+plastics%22">Biodegradable plastics</searchLink><br /><searchLink fieldCode="DE" term="%22Postoperative+care%22">Postoperative care</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cataracts affect millions of people worldwide; surgery and intensive post-operative care are the current standard of treatment. However, ocular barriers to drug delivery often impede recovery after surgery. This study proposes a potential solution to enhance post-cataract care by developing a biodegradable, controlled-release implant using 3D printing technology and follows the guidelines given by the All-India Ophthalmological Society (AIOS). The implant was designed to be placed into the capsular bag of the eye during the surgery and employs Poly(lactic-co-glycolic acid) (PLGA) as a drug carrier, delivering a combination of drugs such as Dexamethasone (DEX), Moxifloxacin (MOX), and Nepafenac (NEPA) directly into the eye. Two sets of drugs loaded implants were prepared, namely DEX-MOX-PLGA and NEPA-PLGA to mimic the conventional administration of corresponding eye drops used in post-operative management. A two-step process involving hot-melt extrusion and 3D printing, was utilised to prepare these implants. The prepared implants were characterised and the in vitro results aligned with the clinically prescribed regimens. The prepared implants were able to overcome the challenges like consistency of size and the in vitro release profile which were encountered in the previously published hot-melt extrusion only study. This approach demonstrates the feasibility of combining cataract surgery with post-operative drug delivery in a single procedure. The implants provided sustained drug release profiles consistent with clinical dosing regimens and were well substantiated in in vivo rabbit model, supporting their potential to improve patient compliance and recovery in future therapeutic applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biomaterials Science -- Polymer Edition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09205063.2025.2561003
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 23
        StartPage: 1441
    Subjects:
      – SubjectFull: Three-dimensional printing
        Type: general
      – SubjectFull: Bioabsorbable implants
        Type: general
      – SubjectFull: Ophthalmology
        Type: general
      – SubjectFull: Cataract surgery
        Type: general
      – SubjectFull: Biodegradable plastics
        Type: general
      – SubjectFull: Postoperative care
        Type: general
      – SubjectFull: Controlled release drugs
        Type: general
    Titles:
      – TitleFull: Development of 3D printed biodegradable polymer-based drug delivery implants for post cataract surgery treatment.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Subhash, Nayana E.
      – PersonEntity:
          Name:
            NameFull: Nair, Soumya
      – PersonEntity:
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            NameFull: Srinivas, Srilatha Parampalli
      – PersonEntity:
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            NameFull: Bhandary, Sulatha V.
      – PersonEntity:
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            NameFull: Guru, Bharath Raja
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            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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              Value: 09205063
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              Value: 37
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Journal of Biomaterials Science -- Polymer Edition
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