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Phytochemical-Loaded Biodegradable Nanoemulsions for Eradication of Fungal Biofilms.

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Title: Phytochemical-Loaded Biodegradable Nanoemulsions for Eradication of Fungal Biofilms.
Authors: Hassan, Muhammad Aamir1 (AUTHOR), Chandrababu, Harini1 (AUTHOR), Park, Jungmi1 (AUTHOR), Rotello, Vincent M.1 (AUTHOR) rotello@chem.umass.edu
Source: Nanomaterials (2079-4991). May2026, Vol. 16 Issue 10, p574. 14p.
Subjects: Biofilms, Candida, Drug resistance in microorganisms, Carvacrol, Polymer structure, Essential oils, Microemulsions
Abstract: Fungal infections are an escalating health threat, especially in hard-to-treat biofilm-associated infections. Candida species are the most widespread drivers of wound biofilm and biomedical device-associated infections. In this study, biodegradable nanoemulsions (BNEs) were fabricated by encapsulating active components of three different essential oils—carvacrol (C-BNE), geraniol (G-BNE), and eugenol (E-BNE)—in a polymeric scaffold with a biodegradable crosslinker. The antibiofilm efficacy of BNEs was assessed against 2-day-old biofilms of multiple Candida species. C-BNE showed maximum effectiveness against all fungal biofilms as compared to G-BNE and E-BNE. Confocal microscopy further demonstrated that C-BNE efficiently penetrated the biofilm and killed the fungal cells by compromising cell membrane integrity. Overall, this study highlights the potential of essential oil-loaded nanoemulsions against drug-resistant biofilm-associated fungal infections. [ABSTRACT FROM AUTHOR]
Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Phytochemical-Loaded Biodegradable Nanoemulsions for Eradication of Fungal Biofilms.
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  Data: <searchLink fieldCode="AR" term="%22Hassan%2C+Muhammad+Aamir%22">Hassan, Muhammad Aamir</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chandrababu%2C+Harini%22">Chandrababu, Harini</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Jungmi%22">Park, Jungmi</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rotello%2C+Vincent+M%2E%22">Rotello, Vincent M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rotello@chem.umass.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Nanomaterials+%282079-4991%29%22">Nanomaterials (2079-4991)</searchLink>. May2026, Vol. 16 Issue 10, p574. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Biofilms%22">Biofilms</searchLink><br /><searchLink fieldCode="DE" term="%22Candida%22">Candida</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance+in+microorganisms%22">Drug resistance in microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22Carvacrol%22">Carvacrol</searchLink><br /><searchLink fieldCode="DE" term="%22Polymer+structure%22">Polymer structure</searchLink><br /><searchLink fieldCode="DE" term="%22Essential+oils%22">Essential oils</searchLink><br /><searchLink fieldCode="DE" term="%22Microemulsions%22">Microemulsions</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Fungal infections are an escalating health threat, especially in hard-to-treat biofilm-associated infections. Candida species are the most widespread drivers of wound biofilm and biomedical device-associated infections. In this study, biodegradable nanoemulsions (BNEs) were fabricated by encapsulating active components of three different essential oils—carvacrol (C-BNE), geraniol (G-BNE), and eugenol (E-BNE)—in a polymeric scaffold with a biodegradable crosslinker. The antibiofilm efficacy of BNEs was assessed against 2-day-old biofilms of multiple Candida species. C-BNE showed maximum effectiveness against all fungal biofilms as compared to G-BNE and E-BNE. Confocal microscopy further demonstrated that C-BNE efficiently penetrated the biofilm and killed the fungal cells by compromising cell membrane integrity. Overall, this study highlights the potential of essential oil-loaded nanoemulsions against drug-resistant biofilm-associated fungal infections. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nanomaterials (2079-4991) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/nano16100574
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      – Code: eng
        Text: English
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        PageCount: 14
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      – SubjectFull: Biofilms
        Type: general
      – SubjectFull: Candida
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      – SubjectFull: Drug resistance in microorganisms
        Type: general
      – SubjectFull: Carvacrol
        Type: general
      – SubjectFull: Polymer structure
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      – SubjectFull: Essential oils
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      – SubjectFull: Microemulsions
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            NameFull: Chandrababu, Harini
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            NameFull: Park, Jungmi
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              Text: May2026
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              Y: 2026
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