Antilipogenic Effect of Cirsium japonicum var. maackii According to Harvest Time and Plant Part in High‐Fat Diet‐Induced Nonalcoholic Fatty Liver Disease.
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| Title: | Antilipogenic Effect of Cirsium japonicum var. maackii According to Harvest Time and Plant Part in High‐Fat Diet‐Induced Nonalcoholic Fatty Liver Disease. |
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| Authors: | Kim, Yeon-Ji1 (AUTHOR), Kim, Ki Mo2,3 (AUTHOR), Kim, Seung-Hyung4 (AUTHOR), Lee, Sanghyun5 (AUTHOR), Hyun, Jin Won6 (AUTHOR), Shim, Ki-Shuk2 (AUTHOR), Kim, Taesoo2 (AUTHOR), Kim, Kyungho1,3 (AUTHOR) jk6012@kiom.re.kr, Chae, Sungwook2,3 (AUTHOR) kendall@kiom.re.kr, Bose, Anupama (AUTHOR) abose@wiley.com |
| Source: | Journal of Food Biochemistry. 5/26/2026, Vol. 2026, p1-13. 13p. |
| Subjects: | Non-alcoholic fatty liver disease, Plant extracts, Lipid metabolism, Metabolism, Fatty acid oxidation, High-fat diet, Milk thistle, Obesity |
| Abstract: | The global rise in obesity has been closely linked to an increasing incidence of nonalcoholic fatty liver disease (NAFLD), a major metabolic disorder. In this study, we evaluated the lipid‐lowering and hepatoprotective effects of Cirsium japonicum var. maackii (CJ) harvested at different times, spring (CJ‐sp), fall (CJ‐fall), and from pappus (CJ‐pap), a tuft of bristles in CJ, in a high‐fat diet (HFD) mouse model. Male C57BL/6 mice were assigned to either a normal control diet (NOR) or HFD, with treatment groups receiving CJ‐sp, CJ‐fall, CJ‐pap (100 and 200 mg/kg), cirsimaritin (Cirsi, 25 mg/kg), or milk thistle (MT, 100 mg/kg). Administration of the CJ extract markedly reduced body weight gain, food efficiency ratio (FER), and serum lipid parameters compared with the HFD control (CTL). Among the extracts, CJ‐sp and CJ‐pap most effectively alleviated hepatic steatosis, as evidenced by decreased fat deposition and reduced inflammatory changes in liver tissue. In addition, CJ‐treated mice displayed significantly lower white adipose tissue mass and smaller adipocyte size than CTL mice. These improvements were associated with the downregulation of hepatic lipogenic genes and activation of fatty acid oxidation pathways. Collectively, CJ supplementation improved metabolic homeostasis and protected against HFD‐induced obesity and liver dysfunction. Notably, CJ‐sp and CJ‐pap exerted greater efficacy than other CJ fractions or MT, suggesting their potential application as functional food ingredients for the prevention of NAFLD. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 194135471 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Antilipogenic Effect of Cirsium japonicum var. maackii According to Harvest Time and Plant Part in High‐Fat Diet‐Induced Nonalcoholic Fatty Liver Disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Yeon-Ji%22">Kim, Yeon-Ji</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Ki+Mo%22">Kim, Ki Mo</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Seung-Hyung%22">Kim, Seung-Hyung</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Sanghyun%22">Lee, Sanghyun</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hyun%2C+Jin+Won%22">Hyun, Jin Won</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shim%2C+Ki-Shuk%22">Shim, Ki-Shuk</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Taesoo%22">Kim, Taesoo</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Kyungho%22">Kim, Kyungho</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> jk6012@kiom.re.kr</i><br /><searchLink fieldCode="AR" term="%22Chae%2C+Sungwook%22">Chae, Sungwook</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<i> kendall@kiom.re.kr</i><br /><searchLink fieldCode="AR" term="%22Bose%2C+Anupama%22">Bose, Anupama</searchLink> (AUTHOR)<i> abose@wiley.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Food+Biochemistry%22">Journal of Food Biochemistry</searchLink>. 5/26/2026, Vol. 2026, p1-13. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Non-alcoholic+fatty+liver+disease%22">Non-alcoholic fatty liver disease</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+extracts%22">Plant extracts</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+metabolism%22">Lipid metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolism%22">Metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Fatty+acid+oxidation%22">Fatty acid oxidation</searchLink><br /><searchLink fieldCode="DE" term="%22High-fat+diet%22">High-fat diet</searchLink><br /><searchLink fieldCode="DE" term="%22Milk+thistle%22">Milk thistle</searchLink><br /><searchLink fieldCode="DE" term="%22Obesity%22">Obesity</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The global rise in obesity has been closely linked to an increasing incidence of nonalcoholic fatty liver disease (NAFLD), a major metabolic disorder. In this study, we evaluated the lipid‐lowering and hepatoprotective effects of Cirsium japonicum var. maackii (CJ) harvested at different times, spring (CJ‐sp), fall (CJ‐fall), and from pappus (CJ‐pap), a tuft of bristles in CJ, in a high‐fat diet (HFD) mouse model. Male C57BL/6 mice were assigned to either a normal control diet (NOR) or HFD, with treatment groups receiving CJ‐sp, CJ‐fall, CJ‐pap (100 and 200 mg/kg), cirsimaritin (Cirsi, 25 mg/kg), or milk thistle (MT, 100 mg/kg). Administration of the CJ extract markedly reduced body weight gain, food efficiency ratio (FER), and serum lipid parameters compared with the HFD control (CTL). Among the extracts, CJ‐sp and CJ‐pap most effectively alleviated hepatic steatosis, as evidenced by decreased fat deposition and reduced inflammatory changes in liver tissue. In addition, CJ‐treated mice displayed significantly lower white adipose tissue mass and smaller adipocyte size than CTL mice. These improvements were associated with the downregulation of hepatic lipogenic genes and activation of fatty acid oxidation pathways. Collectively, CJ supplementation improved metabolic homeostasis and protected against HFD‐induced obesity and liver dysfunction. Notably, CJ‐sp and CJ‐pap exerted greater efficacy than other CJ fractions or MT, suggesting their potential application as functional food ingredients for the prevention of NAFLD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Food Biochemistry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1155/jfbc/3260026 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1 Subjects: – SubjectFull: Non-alcoholic fatty liver disease Type: general – SubjectFull: Plant extracts Type: general – SubjectFull: Lipid metabolism Type: general – SubjectFull: Metabolism Type: general – SubjectFull: Fatty acid oxidation Type: general – SubjectFull: High-fat diet Type: general – SubjectFull: Milk thistle Type: general – SubjectFull: Obesity Type: general Titles: – TitleFull: Antilipogenic Effect of Cirsium japonicum var. maackii According to Harvest Time and Plant Part in High‐Fat Diet‐Induced Nonalcoholic Fatty Liver Disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Yeon-Ji – PersonEntity: Name: NameFull: Kim, Ki Mo – PersonEntity: Name: NameFull: Kim, Seung-Hyung – PersonEntity: Name: NameFull: Lee, Sanghyun – PersonEntity: Name: NameFull: Hyun, Jin Won – PersonEntity: Name: NameFull: Shim, Ki-Shuk – PersonEntity: Name: NameFull: Kim, Taesoo – PersonEntity: Name: NameFull: Kim, Kyungho – PersonEntity: Name: NameFull: Chae, Sungwook – PersonEntity: Name: NameFull: Bose, Anupama IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 05 Text: 5/26/2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 01458884 Numbering: – Type: volume Value: 2026 Titles: – TitleFull: Journal of Food Biochemistry Type: main |
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