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Ciprofloxacin release behaviour from gamma-irradiated dextran-poly(ethylene glycol) diacrylate hydrogel and its kinetic fitting models.

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Title: Ciprofloxacin release behaviour from gamma-irradiated dextran-poly(ethylene glycol) diacrylate hydrogel and its kinetic fitting models.
Authors: Lasmawati, Deudeu1,2 (AUTHOR), Nurlidar, Farah3 (AUTHOR) farah.nurlidar@brin.go.id, Rahayu, Dien Puji3 (AUTHOR), Lukitowati, Fajar3 (AUTHOR), Helmiyati, Helmiyati1 (AUTHOR) helmiyati@sci.ui.ac.id
Source: Journal of Polymer Research. May2026, Vol. 33 Issue 5, p1-14. 14p.
Subjects: Ciprofloxacin, Controlled release technology, Polyethylene glycol, Antibacterial agents, Gamma rays, Dextran, Hydrogels, Drug delivery systems
Abstract: Currently, hydrogels prepared from naturally sourced polymers are frequently utilised as matrices in drug delivery systems, owing to their favourable interaction with biological environments and their ability to encapsulate therapeutic agents effectively. However, these hydrogels often exhibit low mechanical properties, enabling premature degradation and ineffective drug release. In this study, we developed hybrid hydrogels synthesised from dextran, a natural polymer, and poly(ethylene glycol) diacrylate (PEGDA), a synthetic polymer, to create a biocompatible and mechanically stable matrix for controlled drug release. The dextran–PEGDA hydrogels were successfully synthesised using gamma rays at irradiation doses of 15 and 25 kGy. Gel fraction test showed a high gel fraction of more than 90 % for both 15 and 25 kGy hydrogels, indicating the successful formation of a three-dimensional network within the dextran-PEGDA hydrogel. Fourier transform infrared analysis revealed the disappearance of vinyl groups from PEGDA, further confirming the successful formation of crosslinking between the polymers in the hydrogel. Scanning electron microscope images demonstrated that the 25 kGy hydrogel has denser pore structures than the 15 kGy hydrogel. Interestingly, the drug release study showed that the 15 kGy hydrogel can release ciprofloxacin up to 84 % after 24 h of immersion in phosphate-buffered saline solution. Furthermore, the Korsmeyer-Peppas and first-order kinetic models provided a strong fit to the experimental data for 15 and 25 kGy hydrogels, with R2 values higher than 0.95, indicating that the ciprofloxacin release is mainly determined by the ability of the drug to diffuse through the densely crosslinked polymer network. Antibacterial tests showed that both hydrogels exhibited pronounced antibacterial properties toward Escherichia coli and Staphylococcus aureus, implying that the ciprofloxacin incorporated into the network remained pharmacologically active following crosslinking by gamma irradiation. Overall, the study revealed that dextran–PEGDA hydrogels exhibit satisfactory mechanical stability and enable a controlled release pattern, suggesting their suitability for future development of drug delivery systems. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Polymer Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Ciprofloxacin release behaviour from gamma-irradiated dextran-poly(ethylene glycol) diacrylate hydrogel and its kinetic fitting models.
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  Data: <searchLink fieldCode="AR" term="%22Lasmawati%2C+Deudeu%22">Lasmawati, Deudeu</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nurlidar%2C+Farah%22">Nurlidar, Farah</searchLink><relatesTo>3</relatesTo> (AUTHOR)<i> farah.nurlidar@brin.go.id</i><br /><searchLink fieldCode="AR" term="%22Rahayu%2C+Dien+Puji%22">Rahayu, Dien Puji</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lukitowati%2C+Fajar%22">Lukitowati, Fajar</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Helmiyati%2C+Helmiyati%22">Helmiyati, Helmiyati</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> helmiyati@sci.ui.ac.id</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Polymer+Research%22">Journal of Polymer Research</searchLink>. May2026, Vol. 33 Issue 5, p1-14. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Ciprofloxacin%22">Ciprofloxacin</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+technology%22">Controlled release technology</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethylene+glycol%22">Polyethylene glycol</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Gamma+rays%22">Gamma rays</searchLink><br /><searchLink fieldCode="DE" term="%22Dextran%22">Dextran</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink>
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  Group: Ab
  Data: Currently, hydrogels prepared from naturally sourced polymers are frequently utilised as matrices in drug delivery systems, owing to their favourable interaction with biological environments and their ability to encapsulate therapeutic agents effectively. However, these hydrogels often exhibit low mechanical properties, enabling premature degradation and ineffective drug release. In this study, we developed hybrid hydrogels synthesised from dextran, a natural polymer, and poly(ethylene glycol) diacrylate (PEGDA), a synthetic polymer, to create a biocompatible and mechanically stable matrix for controlled drug release. The dextran–PEGDA hydrogels were successfully synthesised using gamma rays at irradiation doses of 15 and 25 kGy. Gel fraction test showed a high gel fraction of more than 90 % for both 15 and 25 kGy hydrogels, indicating the successful formation of a three-dimensional network within the dextran-PEGDA hydrogel. Fourier transform infrared analysis revealed the disappearance of vinyl groups from PEGDA, further confirming the successful formation of crosslinking between the polymers in the hydrogel. Scanning electron microscope images demonstrated that the 25 kGy hydrogel has denser pore structures than the 15 kGy hydrogel. Interestingly, the drug release study showed that the 15 kGy hydrogel can release ciprofloxacin up to 84 % after 24 h of immersion in phosphate-buffered saline solution. Furthermore, the Korsmeyer-Peppas and first-order kinetic models provided a strong fit to the experimental data for 15 and 25 kGy hydrogels, with R2 values higher than 0.95, indicating that the ciprofloxacin release is mainly determined by the ability of the drug to diffuse through the densely crosslinked polymer network. Antibacterial tests showed that both hydrogels exhibited pronounced antibacterial properties toward Escherichia coli and Staphylococcus aureus, implying that the ciprofloxacin incorporated into the network remained pharmacologically active following crosslinking by gamma irradiation. Overall, the study revealed that dextran–PEGDA hydrogels exhibit satisfactory mechanical stability and enable a controlled release pattern, suggesting their suitability for future development of drug delivery systems. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Polymer Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1007/s10965-026-04906-6
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 14
        StartPage: 1
    Subjects:
      – SubjectFull: Ciprofloxacin
        Type: general
      – SubjectFull: Controlled release technology
        Type: general
      – SubjectFull: Polyethylene glycol
        Type: general
      – SubjectFull: Antibacterial agents
        Type: general
      – SubjectFull: Gamma rays
        Type: general
      – SubjectFull: Dextran
        Type: general
      – SubjectFull: Hydrogels
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
    Titles:
      – TitleFull: Ciprofloxacin release behaviour from gamma-irradiated dextran-poly(ethylene glycol) diacrylate hydrogel and its kinetic fitting models.
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            NameFull: Lasmawati, Deudeu
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            NameFull: Nurlidar, Farah
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            NameFull: Rahayu, Dien Puji
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            NameFull: Lukitowati, Fajar
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            NameFull: Helmiyati, Helmiyati
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            – D: 01
              M: 05
              Text: May2026
              Type: published
              Y: 2026
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              Value: 33
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