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Zirconium-Triggered Aggregation-Induced Emission of Copper Nanoclusters for the Sensitive Fluorescent Detection of Acid Phosphatase.

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Title: Zirconium-Triggered Aggregation-Induced Emission of Copper Nanoclusters for the Sensitive Fluorescent Detection of Acid Phosphatase.
Authors: Ma, Fanghui1 (AUTHOR), Xue, Yijiong1,2 (AUTHOR) xueyijiong1122@163.com, Yang, Minghui1 (AUTHOR) yangminghui@csu.edu.cn
Source: Journal of Fluorescence. May2026, Vol. 36 Issue 5, p3391-3399. 9p.
Subjects: Acid phosphatase, Copper clusters, Metal ions, Zirconium, Fluorescent probes, Photoluminescence, Routine diagnostic tests, Hydrolases
Abstract: Acid phosphatase (ACP) serves as a vital clinical biomarker for the diagnosis of various pathological conditions. Herein, a sensitive fluorescent platform was developed for ACP detection, leveraging biocompatible Zr4+ ions as a molecular trigger for aggregation-induced emission (AIE) of 4,6-diamino-2-mercaptopyrimidine-capped copper nanoclusters (DAMP-CuNCs). The coordination between Zr4+ and N atoms of the DAMP ligands facilitated the self-assembly of CuNCs into micro-scale aggregates, thereby significantly amplifying the fluorescence intensity. In the presence of ACP, the enzymatic hydrolysis of the substrate L-ascorbic acid-2-phosphate (AAP) produced inorganic phosphate groups (PO43−). Owing to the superior affinity of Zr4+ toward phosphate, the pre-formed aggregates were effectively dissociated through a competitive coordination mechanism, leading to a significant "Turn-Off" fluorescence state. Under optimized conditions, the assay exhibited a wide linear range from 0.1 to 20 U/L for ACP analysis, with a low detection limit (LOD) of 0.04 U/L. Furthermore, the assay was successfully applied to the determination of ACP in human serum samples, demonstrating its great potential for clinical diagnostics and biological research. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Fluorescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 194200086
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Zirconium-Triggered Aggregation-Induced Emission of Copper Nanoclusters for the Sensitive Fluorescent Detection of Acid Phosphatase.
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  Data: <searchLink fieldCode="AR" term="%22Ma%2C+Fanghui%22">Ma, Fanghui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xue%2C+Yijiong%22">Xue, Yijiong</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> xueyijiong1122@163.com</i><br /><searchLink fieldCode="AR" term="%22Yang%2C+Minghui%22">Yang, Minghui</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yangminghui@csu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Fluorescence%22">Journal of Fluorescence</searchLink>. May2026, Vol. 36 Issue 5, p3391-3399. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Acid+phosphatase%22">Acid phosphatase</searchLink><br /><searchLink fieldCode="DE" term="%22Copper+clusters%22">Copper clusters</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+ions%22">Metal ions</searchLink><br /><searchLink fieldCode="DE" term="%22Zirconium%22">Zirconium</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorescent+probes%22">Fluorescent probes</searchLink><br /><searchLink fieldCode="DE" term="%22Photoluminescence%22">Photoluminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Routine+diagnostic+tests%22">Routine diagnostic tests</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrolases%22">Hydrolases</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Acid phosphatase (ACP) serves as a vital clinical biomarker for the diagnosis of various pathological conditions. Herein, a sensitive fluorescent platform was developed for ACP detection, leveraging biocompatible Zr4+ ions as a molecular trigger for aggregation-induced emission (AIE) of 4,6-diamino-2-mercaptopyrimidine-capped copper nanoclusters (DAMP-CuNCs). The coordination between Zr4+ and N atoms of the DAMP ligands facilitated the self-assembly of CuNCs into micro-scale aggregates, thereby significantly amplifying the fluorescence intensity. In the presence of ACP, the enzymatic hydrolysis of the substrate L-ascorbic acid-2-phosphate (AAP) produced inorganic phosphate groups (PO43−). Owing to the superior affinity of Zr4+ toward phosphate, the pre-formed aggregates were effectively dissociated through a competitive coordination mechanism, leading to a significant "Turn-Off" fluorescence state. Under optimized conditions, the assay exhibited a wide linear range from 0.1 to 20 U/L for ACP analysis, with a low detection limit (LOD) of 0.04 U/L. Furthermore, the assay was successfully applied to the determination of ACP in human serum samples, demonstrating its great potential for clinical diagnostics and biological research. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Fluorescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1007/s10895-026-04780-x
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 3391
    Subjects:
      – SubjectFull: Acid phosphatase
        Type: general
      – SubjectFull: Copper clusters
        Type: general
      – SubjectFull: Metal ions
        Type: general
      – SubjectFull: Zirconium
        Type: general
      – SubjectFull: Fluorescent probes
        Type: general
      – SubjectFull: Photoluminescence
        Type: general
      – SubjectFull: Routine diagnostic tests
        Type: general
      – SubjectFull: Hydrolases
        Type: general
    Titles:
      – TitleFull: Zirconium-Triggered Aggregation-Induced Emission of Copper Nanoclusters for the Sensitive Fluorescent Detection of Acid Phosphatase.
        Type: main
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          Name:
            NameFull: Ma, Fanghui
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            NameFull: Xue, Yijiong
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            NameFull: Yang, Minghui
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            – D: 01
              M: 05
              Text: May2026
              Type: published
              Y: 2026
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              Value: 36
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            – TitleFull: Journal of Fluorescence
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