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A novel titanium-Schiff base complex for targeting triple negative breast cancer: synthesis, characterisation, and apoptosis induction.

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Title: A novel titanium-Schiff base complex for targeting triple negative breast cancer: synthesis, characterisation, and apoptosis induction.
Authors: Chethana, M. H.1 (AUTHOR), Priyadarshini, A.N.2,3 (AUTHOR), Sudhanva, M.S.2,3 (AUTHOR), Rangappa, Shobith2,3 (AUTHOR), Mallu, P.1 (AUTHOR) pmallu@jssstuniv.in
Source: Materials Research Innovations. Jun2026, Vol. 30 Issue 4, p410-419. 10p.
Subjects: Triple-negative breast cancer, Metal complexes, Titanium, Antineoplastic agents, Thermal stability, Apoptosis, Schiff bases, Molecular docking
Abstract: Breast cancer is the most prevalent cancer among women globally, highlighting the need for alternative metal-based therapies. In the present work, dopamine-derived Schiff base Ti(IV) complex was synthesized and characterized to assess its structural, thermal, and biological attributes. Spectroscopic studies confirmed the existence of a six-coordinated titanium complex, while thermogravimetric analysis indicated significant thermal stability with TiO₂ formation above 600 °C. The complex demonstrated significant in vitro anticancer efficacy against the MDA-MB-231 cell line, with IC₅₀ values between 60–80 µM, showing enhanced sensitivity relative to HeLa cells. Fluorescence staining with Hoechst and propidium iodide revealed apoptosis-related nuclear and membrane changes. Molecular docking studies corroborated the experimental data, indicating robust binding interactions with a binding energy of −9.69 kcal/mol. These findings underscore the potential of dopamine-based Ti(IV) complexes as promising candidates for anticancer therapies. [ABSTRACT FROM AUTHOR]
Copyright of Materials Research Innovations is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 194222813
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  Label: Title
  Group: Ti
  Data: A novel titanium-Schiff base complex for targeting triple negative breast cancer: synthesis, characterisation, and apoptosis induction.
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  Data: <searchLink fieldCode="JN" term="%22Materials+Research+Innovations%22">Materials Research Innovations</searchLink>. Jun2026, Vol. 30 Issue 4, p410-419. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Triple-negative+breast+cancer%22">Triple-negative breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+complexes%22">Metal complexes</searchLink><br /><searchLink fieldCode="DE" term="%22Titanium%22">Titanium</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Thermal+stability%22">Thermal stability</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Schiff+bases%22">Schiff bases</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+docking%22">Molecular docking</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Breast cancer is the most prevalent cancer among women globally, highlighting the need for alternative metal-based therapies. In the present work, dopamine-derived Schiff base Ti(IV) complex was synthesized and characterized to assess its structural, thermal, and biological attributes. Spectroscopic studies confirmed the existence of a six-coordinated titanium complex, while thermogravimetric analysis indicated significant thermal stability with TiO₂ formation above 600 °C. The complex demonstrated significant in vitro anticancer efficacy against the MDA-MB-231 cell line, with IC₅₀ values between 60–80 µM, showing enhanced sensitivity relative to HeLa cells. Fluorescence staining with Hoechst and propidium iodide revealed apoptosis-related nuclear and membrane changes. Molecular docking studies corroborated the experimental data, indicating robust binding interactions with a binding energy of −9.69 kcal/mol. These findings underscore the potential of dopamine-based Ti(IV) complexes as promising candidates for anticancer therapies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Materials Research Innovations is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1080/14328917.2025.2604696
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      – Code: eng
        Text: English
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        StartPage: 410
    Subjects:
      – SubjectFull: Triple-negative breast cancer
        Type: general
      – SubjectFull: Metal complexes
        Type: general
      – SubjectFull: Titanium
        Type: general
      – SubjectFull: Antineoplastic agents
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      – SubjectFull: Thermal stability
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      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Schiff bases
        Type: general
      – SubjectFull: Molecular docking
        Type: general
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      – TitleFull: A novel titanium-Schiff base complex for targeting triple negative breast cancer: synthesis, characterisation, and apoptosis induction.
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            NameFull: Chethana, M. H.
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              M: 06
              Text: Jun2026
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              Y: 2026
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