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Antimony–dithiocarbamate complexes: From coordination and speciation to antimicrobial, anticancer, antioxidant, and antileishmanial applications.

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Title: Antimony–dithiocarbamate complexes: From coordination and speciation to antimicrobial, anticancer, antioxidant, and antileishmanial applications.
Authors: Verma, Deepika1 (AUTHOR), Singh, Poonam C.2 (AUTHOR), Mir, Snober S.3 (AUTHOR), Prakash, Om1 (AUTHOR) prakash_om@lkouniv.ac.in
Source: Inorganica Chimica Acta. Oct2026, Vol. 601, pN.PAG-N.PAG. 1p.
Subjects: Antimony compounds, Dithiocarbamates, Antioxidants, Coordinate covalent bond, Antineoplastic agents, Anti-infective agents, Leishmaniasis, Oxidation-reduction reaction
Abstract: Antimony dithiocarbamate (Sb-DTC) complexes form a distinctive class of sulfur-rich metallodrugs. Their biological behavior is governed by coordination geometry, solution speciation, and redox reactivity. The stereochemically active lone pair on Sb(III) induces hemidirected coordination and anisobidentate S,S-chelation. These features control stability and target engagement in biological media. This review provides a comprehensive account of the synthesis, coordination chemistry, spectroscopic signatures, and bioactivity of Sb(III)–DTC complexes. Structural features are critically correlated with enzyme-associated bioactivity, with particular emphasis on thioredoxin reductase and lipoxygenase (LOX) inhibition, mitochondrial dysfunction, redox imbalance, and DNA interactions. These mechanisms collectively underpin the reported anticancer, antimicrobial, and antileishmanial activities of Sb(III)–DTC systems. By integrating crystallographic, spectroscopic, computational, and biological evidence, this review establishes key structure–mechanism relationships. On this basis, practical design principles for the development of Sb(III)–DTC based metallodrugs are proposed. Synthesis of mono and binuclear antimony–dithiocarbamate complexes linking coordination chemistry to antimicrobial, antileishmanial, antioxidant, and anticancer applications. [Display omitted] • Antimony–dithiocarbamate complexes show broad antimicrobial, anticancer effects. • Stereochemistry, steric factor and ligand design control binding and geometry. • Solution speciation in physiological media governs exposure and potency. • Mechanisms implicate thioredoxin reductase, lipoxygenase, DNA, mitochondria. • Computational and in vivo benchmarks prioritize stable, selective leads. [ABSTRACT FROM AUTHOR]
Copyright of Inorganica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 194294946
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Antimony–dithiocarbamate complexes: From coordination and speciation to antimicrobial, anticancer, antioxidant, and antileishmanial applications.
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  Data: <searchLink fieldCode="AR" term="%22Verma%2C+Deepika%22">Verma, Deepika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+Poonam+C%2E%22">Singh, Poonam C.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mir%2C+Snober+S%2E%22">Mir, Snober S.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prakash%2C+Om%22">Prakash, Om</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> prakash_om@lkouniv.ac.in</i>
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  Data: <searchLink fieldCode="JN" term="%22Inorganica+Chimica+Acta%22">Inorganica Chimica Acta</searchLink>. Oct2026, Vol. 601, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Antimony+compounds%22">Antimony compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Dithiocarbamates%22">Dithiocarbamates</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Coordinate+covalent+bond%22">Coordinate covalent bond</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-infective+agents%22">Anti-infective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Leishmaniasis%22">Leishmaniasis</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidation-reduction+reaction%22">Oxidation-reduction reaction</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Antimony dithiocarbamate (Sb-DTC) complexes form a distinctive class of sulfur-rich metallodrugs. Their biological behavior is governed by coordination geometry, solution speciation, and redox reactivity. The stereochemically active lone pair on Sb(III) induces hemidirected coordination and anisobidentate S,S-chelation. These features control stability and target engagement in biological media. This review provides a comprehensive account of the synthesis, coordination chemistry, spectroscopic signatures, and bioactivity of Sb(III)–DTC complexes. Structural features are critically correlated with enzyme-associated bioactivity, with particular emphasis on thioredoxin reductase and lipoxygenase (LOX) inhibition, mitochondrial dysfunction, redox imbalance, and DNA interactions. These mechanisms collectively underpin the reported anticancer, antimicrobial, and antileishmanial activities of Sb(III)–DTC systems. By integrating crystallographic, spectroscopic, computational, and biological evidence, this review establishes key structure–mechanism relationships. On this basis, practical design principles for the development of Sb(III)–DTC based metallodrugs are proposed. Synthesis of mono and binuclear antimony–dithiocarbamate complexes linking coordination chemistry to antimicrobial, antileishmanial, antioxidant, and anticancer applications. [Display omitted] • Antimony–dithiocarbamate complexes show broad antimicrobial, anticancer effects. • Stereochemistry, steric factor and ligand design control binding and geometry. • Solution speciation in physiological media governs exposure and potency. • Mechanisms implicate thioredoxin reductase, lipoxygenase, DNA, mitochondria. • Computational and in vivo benchmarks prioritize stable, selective leads. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Inorganica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.ica.2026.123277
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Antimony compounds
        Type: general
      – SubjectFull: Dithiocarbamates
        Type: general
      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Coordinate covalent bond
        Type: general
      – SubjectFull: Antineoplastic agents
        Type: general
      – SubjectFull: Anti-infective agents
        Type: general
      – SubjectFull: Leishmaniasis
        Type: general
      – SubjectFull: Oxidation-reduction reaction
        Type: general
    Titles:
      – TitleFull: Antimony–dithiocarbamate complexes: From coordination and speciation to antimicrobial, anticancer, antioxidant, and antileishmanial applications.
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            NameFull: Verma, Deepika
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            NameFull: Singh, Poonam C.
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            NameFull: Mir, Snober S.
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            NameFull: Prakash, Om
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            – D: 01
              M: 10
              Text: Oct2026
              Type: published
              Y: 2026
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              Value: 601
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