View in EDS

Catheter Ablation of Ventricular Tachycardia in Patients Awaiting Heart Transplantation: Practice and Perspectives.

Saved in:
Bibliographic Details
Title: Catheter Ablation of Ventricular Tachycardia in Patients Awaiting Heart Transplantation: Practice and Perspectives.
Authors: Preda, Alberto1 (AUTHOR) alberto.preda@ospedaleniguarda.it, Guarracini, Fabrizio1 (AUTHOR), Falasconi, Giulio2,3 (AUTHOR), Schiavone, Marco4 (AUTHOR), Latini, Alessia Chiara5,6 (AUTHOR), Cersosimo, Angelica7 (AUTHOR), Villaschi, Alessandro5,8 (AUTHOR), Sabatino, Mariano4 (AUTHOR), Falco, Raffaele1 (AUTHOR), De Luca, Luigi9 (AUTHOR), Ramadan, Ahmed1 (AUTHOR), Penela, Diego5,6 (AUTHOR), Ammirati, Enrico10 (AUTHOR), Carbucicchio, Corrado4 (AUTHOR), Frontera, Antonio1 (AUTHOR), Mazzone, Patrizio1 (AUTHOR), Gigli, Lorenzo1 (AUTHOR)
Source: Pacing & Clinical Electrophysiology. Jun2026, Vol. 49 Issue 6, p717-732. 16p.
Subjects: Patient selection, Patient safety, Cardiomyopathies, Body surface mapping, Treatment effectiveness, Heart failure, Severity of illness index, Heart transplantation, Ventricular tachycardia, Catheter ablation, Disease risk factors
Abstract: Advanced Heart failure (adHF) is the final common pathway of multiple cardiovascular diseases and affects over 64 million people worldwide. Ventricular arrhythmias (VAs), including electrical storm, are part of the natural history of adHF, being associated with morbidity, mortality, and missing of effective therapeutic options. Management often requires intensive care, deep sedation, autonomic modulation, multiple antiarrhythmic drugs, and mechanical circulatory support (MCS), while non‐responders have very limited alternatives. Heart transplantation (HTx) remains the gold standard therapy, although its availability is constrained by the lack of donors and strict allocation criteria. VAs are major drivers of urgent HTx listing across allocation systems. In recent years, catheter ablation (CA) has evolved into a disease‐modifying therapy for scar‐related VAs, with improvements in safety, mapping resolution, and procedural efficacy. Although randomized data in adHF populations remain limited, observational studies and contemporary trials demonstrate that CA can significantly reduce arrhythmic burden, implantable cardioverter‐defibrillator shocks, hospitalizations, and the need for urgent HTx, particularly when performed early in the disease course. Advances in substrate‐based strategies, functional mapping, multipolar and omnipolar technologies, and integration of cardiac imaging have enhanced procedural precision, while preprocedural risk stratification tools guide the use of MCS to improve safety in high‐risk patients. Emerging therapies, including pulsed‐field ablation, stereotactic arrhythmia radiotherapy, and autonomic modulation, alongside multimodal imaging, are expanding treatment options for refractory VAs in end‐stage cardiomyopathy. This review provides a comprehensive state‐of‐the‐art overview of VA mechanisms, patient selection, ablation strategies, and future directions in the management of severe VAs in adHF, with a focus on patients awaiting HTx. [ABSTRACT FROM AUTHOR]
Copyright of Pacing & Clinical Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 194361727
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Catheter Ablation of Ventricular Tachycardia in Patients Awaiting Heart Transplantation: Practice and Perspectives.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Preda%2C+Alberto%22">Preda, Alberto</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> alberto.preda@ospedaleniguarda.it</i><br /><searchLink fieldCode="AR" term="%22Guarracini%2C+Fabrizio%22">Guarracini, Fabrizio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Falasconi%2C+Giulio%22">Falasconi, Giulio</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schiavone%2C+Marco%22">Schiavone, Marco</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Latini%2C+Alessia+Chiara%22">Latini, Alessia Chiara</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cersosimo%2C+Angelica%22">Cersosimo, Angelica</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Villaschi%2C+Alessandro%22">Villaschi, Alessandro</searchLink><relatesTo>5,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sabatino%2C+Mariano%22">Sabatino, Mariano</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Falco%2C+Raffaele%22">Falco, Raffaele</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Luca%2C+Luigi%22">De Luca, Luigi</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramadan%2C+Ahmed%22">Ramadan, Ahmed</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Penela%2C+Diego%22">Penela, Diego</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ammirati%2C+Enrico%22">Ammirati, Enrico</searchLink><relatesTo>10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carbucicchio%2C+Corrado%22">Carbucicchio, Corrado</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frontera%2C+Antonio%22">Frontera, Antonio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mazzone%2C+Patrizio%22">Mazzone, Patrizio</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gigli%2C+Lorenzo%22">Gigli, Lorenzo</searchLink><relatesTo>1</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Pacing+%26+Clinical+Electrophysiology%22">Pacing & Clinical Electrophysiology</searchLink>. Jun2026, Vol. 49 Issue 6, p717-732. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Patient+selection%22">Patient selection</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+safety%22">Patient safety</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiomyopathies%22">Cardiomyopathies</searchLink><br /><searchLink fieldCode="DE" term="%22Body+surface+mapping%22">Body surface mapping</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+failure%22">Heart failure</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+transplantation%22">Heart transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Ventricular+tachycardia%22">Ventricular tachycardia</searchLink><br /><searchLink fieldCode="DE" term="%22Catheter+ablation%22">Catheter ablation</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Advanced Heart failure (adHF) is the final common pathway of multiple cardiovascular diseases and affects over 64 million people worldwide. Ventricular arrhythmias (VAs), including electrical storm, are part of the natural history of adHF, being associated with morbidity, mortality, and missing of effective therapeutic options. Management often requires intensive care, deep sedation, autonomic modulation, multiple antiarrhythmic drugs, and mechanical circulatory support (MCS), while non‐responders have very limited alternatives. Heart transplantation (HTx) remains the gold standard therapy, although its availability is constrained by the lack of donors and strict allocation criteria. VAs are major drivers of urgent HTx listing across allocation systems. In recent years, catheter ablation (CA) has evolved into a disease‐modifying therapy for scar‐related VAs, with improvements in safety, mapping resolution, and procedural efficacy. Although randomized data in adHF populations remain limited, observational studies and contemporary trials demonstrate that CA can significantly reduce arrhythmic burden, implantable cardioverter‐defibrillator shocks, hospitalizations, and the need for urgent HTx, particularly when performed early in the disease course. Advances in substrate‐based strategies, functional mapping, multipolar and omnipolar technologies, and integration of cardiac imaging have enhanced procedural precision, while preprocedural risk stratification tools guide the use of MCS to improve safety in high‐risk patients. Emerging therapies, including pulsed‐field ablation, stereotactic arrhythmia radiotherapy, and autonomic modulation, alongside multimodal imaging, are expanding treatment options for refractory VAs in end‐stage cardiomyopathy. This review provides a comprehensive state‐of‐the‐art overview of VA mechanisms, patient selection, ablation strategies, and future directions in the management of severe VAs in adHF, with a focus on patients awaiting HTx. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pacing & Clinical Electrophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=194361727
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/pace.70222
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 717
    Subjects:
      – SubjectFull: Patient selection
        Type: general
      – SubjectFull: Patient safety
        Type: general
      – SubjectFull: Cardiomyopathies
        Type: general
      – SubjectFull: Body surface mapping
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Heart failure
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: Heart transplantation
        Type: general
      – SubjectFull: Ventricular tachycardia
        Type: general
      – SubjectFull: Catheter ablation
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
    Titles:
      – TitleFull: Catheter Ablation of Ventricular Tachycardia in Patients Awaiting Heart Transplantation: Practice and Perspectives.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Preda, Alberto
      – PersonEntity:
          Name:
            NameFull: Guarracini, Fabrizio
      – PersonEntity:
          Name:
            NameFull: Falasconi, Giulio
      – PersonEntity:
          Name:
            NameFull: Schiavone, Marco
      – PersonEntity:
          Name:
            NameFull: Latini, Alessia Chiara
      – PersonEntity:
          Name:
            NameFull: Cersosimo, Angelica
      – PersonEntity:
          Name:
            NameFull: Villaschi, Alessandro
      – PersonEntity:
          Name:
            NameFull: Sabatino, Mariano
      – PersonEntity:
          Name:
            NameFull: Falco, Raffaele
      – PersonEntity:
          Name:
            NameFull: De Luca, Luigi
      – PersonEntity:
          Name:
            NameFull: Ramadan, Ahmed
      – PersonEntity:
          Name:
            NameFull: Penela, Diego
      – PersonEntity:
          Name:
            NameFull: Ammirati, Enrico
      – PersonEntity:
          Name:
            NameFull: Carbucicchio, Corrado
      – PersonEntity:
          Name:
            NameFull: Frontera, Antonio
      – PersonEntity:
          Name:
            NameFull: Mazzone, Patrizio
      – PersonEntity:
          Name:
            NameFull: Gigli, Lorenzo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 01478389
          Numbering:
            – Type: volume
              Value: 49
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Pacing & Clinical Electrophysiology
              Type: main
ResultId 1