Position-dependent feedback drives scaling and robustness of morphogen gradients.
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| Title: | Position-dependent feedback drives scaling and robustness of morphogen gradients. |
|---|---|
| Authors: | Mosby, Lewis Scott1,2,3, Hadjivasiliou, Zena1,2,3 zena.hadjivasiliou@ucl.ac.uk |
| Source: | Proceedings of the National Academy of Sciences of the United States of America. 5/26/2026, Vol. 123 Issue 21, p1-10. 10p. |
| Subjects: | Pattern formation (Biology), Feedback control systems, Cellular signal transduction, Biological evolution, Perturbation theory |
| Abstract: | Developmental patterning is remarkably robust to intrinsic and extrinsic variation. Morphogen gradients are a key mechanism driving patterning, and themselves often scale with the size of developing tissues and exhibit robustness to other perturbations. Recent data indicate that expander molecules, thought to drive morphogen scaling through expansion-repression (ER) feedback, have concentration profiles that are position dependent.This challengesthe currently accepted ER mechanism thatrequires uniform expander concentrations and position independent feedback. To reconcile these observations, we introduce an ER motif that supports morphogen scaling with both uniform and position-dependent expander concentrations. We quantify scaling as a function of position, and demonstrate thatthe spatial profiles ofscaling and robustness to perturbationsin morphogen production are highly correlated.In contrast to uniform expander concentrations that can confer high levels of scaling and robustness at a single position, position-dependent expander concentrations can enhance both scaling and robustness throughout the entire target tissue. We explore trade-offs associated with the dynamic range of the expander concentration, revealing that it can be varied to tune the locations where morphogen gradients confer scaling, robustness, and precision simultaneously. These findings offer insight into how developmental systems balance competing demands to achieve reproducible patterning despite biological variability. [ABSTRACT FROM AUTHOR] |
| Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 194395511 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2521182123 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1 Subjects: – SubjectFull: Pattern formation (Biology) Type: general – SubjectFull: Feedback control systems Type: general – SubjectFull: Cellular signal transduction Type: general – SubjectFull: Biological evolution Type: general – SubjectFull: Perturbation theory Type: general Titles: – TitleFull: Position-dependent feedback drives scaling and robustness of morphogen gradients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mosby, Lewis Scott – PersonEntity: Name: NameFull: Hadjivasiliou, Zena IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 05 Text: 5/26/2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00278424 Numbering: – Type: volume Value: 123 – Type: issue Value: 21 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
| ResultId | 1 |
