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Anti‐solvent crystallization for the preparation of drug nanocrystals via amphiphilic copolymer (AcMH‐b‐PEG) micelles as soft templates.

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Title: Anti‐solvent crystallization for the preparation of drug nanocrystals via amphiphilic copolymer (AcMH‐b‐PEG) micelles as soft templates.
Authors: Wang, Yini1 (AUTHOR), Lou, Boxuan1 (AUTHOR), Xu, Yue1 (AUTHOR), Yuan, Haikuan1 (AUTHOR) yhk12345@163.com, Lu, Jie1 (AUTHOR) lujie@sues.edu.cn
Source: Canadian Journal of Chemical Engineering. Jul2026, Vol. 104 Issue 7, p3840-3857. 18p.
Subjects: Copolymer micelles, Crystallization, Block copolymers, Medical polymers, Nanomedicine, Nanocrystals, Controlled release drugs, Isoflavonoids
Abstract: Nanometerization of drug particles as a well‐regarded approach can enhance the solubility and bioavailability of water‐insoluble drugs. (R)‐Equol is frequently employed in research for its ability to inhibit the replication of cancer cells, but the application of (R)‐equol is still limited by its water‐insoluble nature. Novel biocompatible polymeric micelles were prepared through the self‐assembly of amphiphilic block copolymers composed of acetylated maltoheptose‐b‐polyethylene glycol (AcMH‐b‐PEG) in water. Using AcMH‐b‐PEG micelles as templates, (R)‐equol nanocrystals with good crystallinity and regular morphology were prepared by a micelle‐mediated anti‐solvent crystallization method. These nanocrystals were identified as an isolated‐site hydrate form of (R)‐equol, stabilized by a robust three‐dimensional hydrogen‐bonding network and distinct from those obtained via conventional methods. In vitro release experiment showed that AcMH‐b‐PEG micelle exhibited a sustained‐release effect on (R)‐equol, with the drug being released slowly and continuously. In mouse plasma, the cumulative release reached 65.70% over 24 h. In particular, it was found that (R)‐equol was more readily released under acidic milieus. This study demonstrated that using amphiphilic micelles as templates for anti‐solvent crystallization represented a potent and robust approach to prepare crystalline nanodrugs. [ABSTRACT FROM AUTHOR]
Copyright of Canadian Journal of Chemical Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Anti‐solvent crystallization for the preparation of drug nanocrystals via amphiphilic copolymer (AcMH‐b‐PEG) micelles as soft templates.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Yini%22">Wang, Yini</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lou%2C+Boxuan%22">Lou, Boxuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Yue%22">Xu, Yue</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Haikuan%22">Yuan, Haikuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> yhk12345@163.com</i><br /><searchLink fieldCode="AR" term="%22Lu%2C+Jie%22">Lu, Jie</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lujie@sues.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Canadian+Journal+of+Chemical+Engineering%22">Canadian Journal of Chemical Engineering</searchLink>. Jul2026, Vol. 104 Issue 7, p3840-3857. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Copolymer+micelles%22">Copolymer micelles</searchLink><br /><searchLink fieldCode="DE" term="%22Crystallization%22">Crystallization</searchLink><br /><searchLink fieldCode="DE" term="%22Block+copolymers%22">Block copolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+polymers%22">Medical polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Nanocrystals%22">Nanocrystals</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+release+drugs%22">Controlled release drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Isoflavonoids%22">Isoflavonoids</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Nanometerization of drug particles as a well‐regarded approach can enhance the solubility and bioavailability of water‐insoluble drugs. (R)‐Equol is frequently employed in research for its ability to inhibit the replication of cancer cells, but the application of (R)‐equol is still limited by its water‐insoluble nature. Novel biocompatible polymeric micelles were prepared through the self‐assembly of amphiphilic block copolymers composed of acetylated maltoheptose‐b‐polyethylene glycol (AcMH‐b‐PEG) in water. Using AcMH‐b‐PEG micelles as templates, (R)‐equol nanocrystals with good crystallinity and regular morphology were prepared by a micelle‐mediated anti‐solvent crystallization method. These nanocrystals were identified as an isolated‐site hydrate form of (R)‐equol, stabilized by a robust three‐dimensional hydrogen‐bonding network and distinct from those obtained via conventional methods. In vitro release experiment showed that AcMH‐b‐PEG micelle exhibited a sustained‐release effect on (R)‐equol, with the drug being released slowly and continuously. In mouse plasma, the cumulative release reached 65.70% over 24 h. In particular, it was found that (R)‐equol was more readily released under acidic milieus. This study demonstrated that using amphiphilic micelles as templates for anti‐solvent crystallization represented a potent and robust approach to prepare crystalline nanodrugs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Canadian Journal of Chemical Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/cjce.70218
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 18
        StartPage: 3840
    Subjects:
      – SubjectFull: Copolymer micelles
        Type: general
      – SubjectFull: Crystallization
        Type: general
      – SubjectFull: Block copolymers
        Type: general
      – SubjectFull: Medical polymers
        Type: general
      – SubjectFull: Nanomedicine
        Type: general
      – SubjectFull: Nanocrystals
        Type: general
      – SubjectFull: Controlled release drugs
        Type: general
      – SubjectFull: Isoflavonoids
        Type: general
    Titles:
      – TitleFull: Anti‐solvent crystallization for the preparation of drug nanocrystals via amphiphilic copolymer (AcMH‐b‐PEG) micelles as soft templates.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Wang, Yini
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            NameFull: Lou, Boxuan
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            NameFull: Xu, Yue
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            NameFull: Yuan, Haikuan
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            NameFull: Lu, Jie
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            – D: 01
              M: 07
              Text: Jul2026
              Type: published
              Y: 2026
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              Value: 00084034
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              Value: 104
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              Value: 7
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            – TitleFull: Canadian Journal of Chemical Engineering
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