Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative.
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| Title: | Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative. |
|---|---|
| Authors: | Naharros‐Molinero, Almudena1 (AUTHOR), Caballo‐González, María Ángela1 (AUTHOR), de la Mata, Francisco Javier2,3,4 (AUTHOR), García‐Gallego, Sandra2,3,4 (AUTHOR) sandra.garciagallego@uah.es |
| Source: | Macromolecular Materials & Engineering. Feb2026, Vol. 311 Issue 2, p1-20. 20p. |
| Subjects: | Dosage forms of drugs, Design techniques, Geriatrics, Bioavailability, Patient compliance, Excipients, Pharmaceutical technology |
| Abstract: | Chewable softgels represent a novel dosage form that significantly enhances patient compliance, particularly among pediatric and geriatric populations. This formulation offers advantages such as ease of use and improved swallowing characteristics, as well as an opportunity for enhancement of the sensorial properties of conventional softgel products. Challenges remain in the formulation process for both shell and fill formulation, including the optimization of the shell chewable properties, the selection of active ingredients and excipients for pharma‐ and nutraceutical applications, ensuring bioavailability, and maintaining product stability throughout its shelf life. A critical aspect of development is the implementation of taste masking strategies to improve palatability. Balancing taste masking with the release efficiency of active ingredients is essential for achieving optimal bioavailability and therapeutic effectiveness, thereby improving patient adherence to medication regimens. Ideally, a combination of effective shell formulations, optimized fill formulations, and advanced taste‐masking strategies culminates in the creation of a product that meets therapeutic requirements while being enjoyable for patients to consume. This review aims to offer a guide for pharmaceutical developers in creating chewable softgel formulations that align with modern expectations of patient‐centric medication delivery. [ABSTRACT FROM AUTHOR] |
| Copyright of Macromolecular Materials & Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 194550002 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Naharros‐Molinero%2C+Almudena%22">Naharros‐Molinero, Almudena</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caballo‐González%2C+María+Ángela%22">Caballo‐González, María Ángela</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+la+Mata%2C+Francisco+Javier%22">de la Mata, Francisco Javier</searchLink><relatesTo>2,3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22García‐Gallego%2C+Sandra%22">García‐Gallego, Sandra</searchLink><relatesTo>2,3,4</relatesTo> (AUTHOR)<i> sandra.garciagallego@uah.es</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Macromolecular+Materials+%26+Engineering%22">Macromolecular Materials & Engineering</searchLink>. Feb2026, Vol. 311 Issue 2, p1-20. 20p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Dosage+forms+of+drugs%22">Dosage forms of drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Design+techniques%22">Design techniques</searchLink><br /><searchLink fieldCode="DE" term="%22Geriatrics%22">Geriatrics</searchLink><br /><searchLink fieldCode="DE" term="%22Bioavailability%22">Bioavailability</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Excipients%22">Excipients</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+technology%22">Pharmaceutical technology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Chewable softgels represent a novel dosage form that significantly enhances patient compliance, particularly among pediatric and geriatric populations. This formulation offers advantages such as ease of use and improved swallowing characteristics, as well as an opportunity for enhancement of the sensorial properties of conventional softgel products. Challenges remain in the formulation process for both shell and fill formulation, including the optimization of the shell chewable properties, the selection of active ingredients and excipients for pharma‐ and nutraceutical applications, ensuring bioavailability, and maintaining product stability throughout its shelf life. A critical aspect of development is the implementation of taste masking strategies to improve palatability. Balancing taste masking with the release efficiency of active ingredients is essential for achieving optimal bioavailability and therapeutic effectiveness, thereby improving patient adherence to medication regimens. Ideally, a combination of effective shell formulations, optimized fill formulations, and advanced taste‐masking strategies culminates in the creation of a product that meets therapeutic requirements while being enjoyable for patients to consume. This review aims to offer a guide for pharmaceutical developers in creating chewable softgel formulations that align with modern expectations of patient‐centric medication delivery. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Macromolecular Materials & Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mame.202500323 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 20 StartPage: 1 Subjects: – SubjectFull: Dosage forms of drugs Type: general – SubjectFull: Design techniques Type: general – SubjectFull: Geriatrics Type: general – SubjectFull: Bioavailability Type: general – SubjectFull: Patient compliance Type: general – SubjectFull: Excipients Type: general – SubjectFull: Pharmaceutical technology Type: general Titles: – TitleFull: Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Naharros‐Molinero, Almudena – PersonEntity: Name: NameFull: Caballo‐González, María Ángela – PersonEntity: Name: NameFull: de la Mata, Francisco Javier – PersonEntity: Name: NameFull: García‐Gallego, Sandra IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 14387492 Numbering: – Type: volume Value: 311 – Type: issue Value: 2 Titles: – TitleFull: Macromolecular Materials & Engineering Type: main |
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