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Cytocompatible Enzymatic Hydrogelation of Phenylboronic Acid‐Alginate via H2O2‐Triggered Deboronation.

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Title: Cytocompatible Enzymatic Hydrogelation of Phenylboronic Acid‐Alginate via H2O2‐Triggered Deboronation.
Authors: Goto, Ryota1 (AUTHOR) goroyota@cheng.es.osaka-u.ac.jp, Sakai, Shinji1 (AUTHOR) sakai@cheng.es.osaka-u.ac.jp
Source: Macromolecular Materials & Engineering. Feb2026, Vol. 311 Issue 2, p1-13. 13p.
Subjects: Hydrogels, Cytocompatibility, Crosslinking (Polymerization), Phenol, Alginic acid, Chemical reactions
Abstract: This study aims to establish a functional hydrogelation system that integrates both dynamic and static properties without the use of additives. Given the increasing demand for biocompatible and mechanically tunable hydrogels, a hydrogelation strategy to prepare hydrogels from a precursor containing 3‐aminophenylboronic acid (3APBA)‐grafted alginate (Alg‐3APBA) and horseradish peroxidase (HRP) via a H2O2‐triggered cascade reaction involving deboronation and subsequent HRP‐mediated crosslinking was developed. Because of the dynamic bonds between 3APBA and 1,2‐diol moieties in the alginate backbone, the obtained Alg‐3APBA precursor exhibited pH‐dependent viscoelasticity. At pH 7.4 and 8.0, in the presence of HRP, the Alg‐3APBA precursor formed phenol–phenol crosslinked hydrogels through the H2O2‐triggered and HRP‐mediated reaction. Furthermore, HepG2 cells were viable and proliferated in the resulting Alg‐3APBA hydrogels prepared with H2O2 (<10 mm) without severe cytotoxicity. These findings highlight the potential of this dynamic‐to‐static transition hydrogelation approach as a cytocompatible and modular platform for future biofunctional materials. [ABSTRACT FROM AUTHOR]
Copyright of Macromolecular Materials & Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hydrogels%22&quot;&gt;Hydrogels&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cytocompatibility%22&quot;&gt;Cytocompatibility&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Crosslinking+%28Polymerization%29%22&quot;&gt;Crosslinking (Polymerization)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Phenol%22&quot;&gt;Phenol&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Alginic+acid%22&quot;&gt;Alginic acid&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Chemical+reactions%22&quot;&gt;Chemical reactions&lt;/searchLink&gt;
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  Data: This study aims to establish a functional hydrogelation system that integrates both dynamic and static properties without the use of additives. Given the increasing demand for biocompatible and mechanically tunable hydrogels, a hydrogelation strategy to prepare hydrogels from a precursor containing 3‐aminophenylboronic acid (3APBA)‐grafted alginate (Alg‐3APBA) and horseradish peroxidase (HRP) via a H2O2‐triggered cascade reaction involving deboronation and subsequent HRP‐mediated crosslinking was developed. Because of the dynamic bonds between 3APBA and 1,2‐diol moieties in the alginate backbone, the obtained Alg‐3APBA precursor exhibited pH‐dependent viscoelasticity. At pH 7.4 and 8.0, in the presence of HRP, the Alg‐3APBA precursor formed phenol–phenol crosslinked hydrogels through the H2O2‐triggered and HRP‐mediated reaction. Furthermore, HepG2 cells were viable and proliferated in the resulting Alg‐3APBA hydrogels prepared with H2O2 (&lt;10 mm) without severe cytotoxicity. These findings highlight the potential of this dynamic‐to‐static transition hydrogelation approach as a cytocompatible and modular platform for future biofunctional materials. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Macromolecular Materials &amp; Engineering is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/mame.202500324
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 13
        StartPage: 1
    Subjects:
      – SubjectFull: Hydrogels
        Type: general
      – SubjectFull: Cytocompatibility
        Type: general
      – SubjectFull: Crosslinking (Polymerization)
        Type: general
      – SubjectFull: Phenol
        Type: general
      – SubjectFull: Alginic acid
        Type: general
      – SubjectFull: Chemical reactions
        Type: general
    Titles:
      – TitleFull: Cytocompatible Enzymatic Hydrogelation of Phenylboronic Acid‐Alginate via H2O2‐Triggered Deboronation.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Goto, Ryota
      – PersonEntity:
          Name:
            NameFull: Sakai, Shinji
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          Dates:
            – D: 01
              M: 02
              Text: Feb2026
              Type: published
              Y: 2026
          Identifiers:
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              Value: 311
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              Value: 2
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            – TitleFull: Macromolecular Materials & Engineering
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